RPC9_CAVPO
ID RPC9_CAVPO Reviewed; 146 AA.
AC Q60482;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=DNA-directed RNA polymerase III subunit RPC9;
DE Short=RNA polymerase III subunit C9;
DE AltName: Full=Calcitonin gene-related peptide-receptor component protein;
DE Short=CGRP-RCP;
DE Short=CGRP-receptor component protein;
DE Short=CGRPRCP;
GN Name=CRCP;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Organ of Corti;
RX PubMed=8622957; DOI=10.1073/pnas.93.8.3455;
RA Luebke A.E., Dahl G.P., Roos B.A., Dickerson I.M.;
RT "Identification of a protein that confers calcitonin gene-related peptide
RT responsiveness to oocytes by using a cystic fibrosis transmembrane
RT conductance regulator assay.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:3455-3460(1996).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific component of RNA polymerase III which synthesizes small RNAs,
CC such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Accessory protein for the calcitonin gene-related peptide
CC (CGRP) receptor. It modulates CGRP responsiveness in a variety of
CC tissues.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of 17 subunits. Interacts with POLR3H/RPC8. POLR3H/RPC8 and
CC CRCP/RPC9 probably form a Pol III subcomplex (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC9 RNA polymerase subunit
CC family. {ECO:0000305}.
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DR EMBL; U50188; AAC52509.1; -; mRNA.
DR RefSeq; NP_001166404.1; NM_001172933.1.
DR AlphaFoldDB; Q60482; -.
DR SMR; Q60482; -.
DR STRING; 10141.ENSCPOP00000017525; -.
DR GeneID; 100135504; -.
DR KEGG; cpoc:100135504; -.
DR CTD; 27297; -.
DR eggNOG; KOG4168; Eukaryota.
DR InParanoid; Q60482; -.
DR OrthoDB; 1634280at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0009360; C:DNA polymerase III complex; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISS:UniProtKB.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IEA:InterPro.
DR Gene3D; 1.20.1250.40; -; 1.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR006590; RNA_pol_Rpb4/RPC9_core.
DR InterPro; IPR005574; Rpb4/RPC9.
DR InterPro; IPR038324; Rpb4/RPC9_sf.
DR InterPro; IPR038846; RPC9.
DR PANTHER; PTHR15561; PTHR15561; 1.
DR Pfam; PF03874; RNA_pol_Rpb4; 1.
DR SMART; SM00657; RPOL4c; 1.
DR SUPFAM; SSF47819; SSF47819; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; DNA-directed RNA polymerase; Membrane; Nucleus;
KW Reference proteome; Transcription.
FT CHAIN 1..146
FT /note="DNA-directed RNA polymerase III subunit RPC9"
FT /id="PRO_0000079334"
SQ SEQUENCE 146 AA; 16781 MW; 1D0E2F94166D082F CRC64;
MEVKDANSAL LSNYEVFQLL TDLKDQRRES GKMKHSAGQQ NLNTITYETL KYLSKTPCRH
QSPEIVREFL TAMKSHKLTK AEKLQLLNHR PMTAVEIQLM VEETEERFTE EEQIEALLHT
VTHILPAEPE VEQMASTEAM EEEGPA
