RPC9_MOUSE
ID RPC9_MOUSE Reviewed; 148 AA.
AC O35427;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=DNA-directed RNA polymerase III subunit RPC9;
DE Short=RNA polymerase III subunit C9;
DE AltName: Full=Calcitonin gene-related peptide-receptor component protein;
DE Short=CGRP-RCP;
DE Short=CGRP-receptor component protein;
DE Short=CGRPRCP;
GN Name=Crcp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9322931; DOI=10.1210/endo.138.10.5447;
RA Naghashpour M., Rosenblatt M.I., Dickerson I.M., Dahl G.P.;
RT "Inhibitory effect of calcitonin gene-related peptide on myometrial
RT contractility is diminished at parturition.";
RL Endocrinology 138:4207-4214(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10067875; DOI=10.1210/endo.140.3.6541;
RA Balkan W., Oates E.L., Howard G.A., Roos B.A.;
RT "Testes exhibit elevated expression of calcitonin gene-related peptide
RT receptor component protein.";
RL Endocrinology 140:1459-1469(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=10903324; DOI=10.1074/jbc.m005604200;
RA Evans B.N., Rosenblatt M.I., Mnayer L.O., Oliver K.R., Dickerson I.M.;
RT "CGRP-RCP, a novel protein required for signal transduction at calcitonin
RT gene-related peptide and adrenomedullin receptors.";
RL J. Biol. Chem. 275:31438-31443(2000).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific peripheric component of RNA polymerase III which synthesizes
CC small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and
CC limiting infection by intracellular bacteria and DNA viruses. Acts as
CC nuclear and cytosolic DNA sensor involved in innate immune response.
CC Can sense non-self dsDNA that serves as template for transcription into
CC dsRNA. The non-self RNA polymerase III transcripts induce type I
CC interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
CC {ECO:0000250}.
CC -!- FUNCTION: Accessory protein for the calcitonin gene-related peptide
CC (CGRP) receptor. It modulates CGRP responsiveness in a variety of
CC tissues.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of 17 subunits. Interacts with POLR3H/RPC8. POLR3H/RPC8 and
CC CRCP/RPC9 probably form a Pol III subcomplex (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell membrane
CC {ECO:0000269|PubMed:10903324}; Peripheral membrane protein
CC {ECO:0000269|PubMed:10903324}; Cytoplasmic side
CC {ECO:0000269|PubMed:10903324}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Most prevalent in testis.
CC {ECO:0000269|PubMed:10067875}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC9 RNA polymerase subunit
CC family. {ECO:0000305}.
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DR EMBL; AF028242; AAB84046.1; -; mRNA.
DR EMBL; AF118271; AAD17244.1; -; mRNA.
DR EMBL; BC012676; AAH12676.1; -; mRNA.
DR CCDS; CCDS19706.1; -.
DR RefSeq; NP_031787.1; NM_007761.2.
DR AlphaFoldDB; O35427; -.
DR SMR; O35427; -.
DR STRING; 10090.ENSMUSP00000026608; -.
DR PhosphoSitePlus; O35427; -.
DR EPD; O35427; -.
DR MaxQB; O35427; -.
DR PaxDb; O35427; -.
DR PeptideAtlas; O35427; -.
DR PRIDE; O35427; -.
DR ProteomicsDB; 260924; -.
DR Antibodypedia; 34815; 108 antibodies from 25 providers.
DR DNASU; 12909; -.
DR Ensembl; ENSMUST00000026608; ENSMUSP00000026608; ENSMUSG00000025532.
DR GeneID; 12909; -.
DR KEGG; mmu:12909; -.
DR UCSC; uc008zua.1; mouse.
DR CTD; 27297; -.
DR MGI; MGI:1100818; Crcp.
DR VEuPathDB; HostDB:ENSMUSG00000025532; -.
DR eggNOG; KOG4168; Eukaryota.
DR GeneTree; ENSGT00390000014189; -.
DR HOGENOM; CLU_092529_5_0_1; -.
DR InParanoid; O35427; -.
DR OMA; VMIINLR; -.
DR OrthoDB; 1634280at2759; -.
DR PhylomeDB; O35427; -.
DR TreeFam; TF323294; -.
DR Reactome; R-MMU-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-MMU-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR Reactome; R-MMU-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR BioGRID-ORCS; 12909; 27 hits in 75 CRISPR screens.
DR ChiTaRS; Crcp; mouse.
DR PRO; PR:O35427; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; O35427; protein.
DR Bgee; ENSMUSG00000025532; Expressed in dentate gyrus of hippocampal formation granule cell and 268 other tissues.
DR ExpressionAtlas; O35427; baseline and differential.
DR Genevisible; O35427; MM.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:MGI.
DR GO; GO:0030424; C:axon; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0030425; C:dendrite; ISO:MGI.
DR GO; GO:0009360; C:DNA polymerase III complex; ISS:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR GO; GO:0001635; F:calcitonin gene-related peptide receptor activity; IDA:MGI.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISS:UniProtKB.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IBA:GO_Central.
DR Gene3D; 1.20.1250.40; -; 1.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR006590; RNA_pol_Rpb4/RPC9_core.
DR InterPro; IPR005574; Rpb4/RPC9.
DR InterPro; IPR038324; Rpb4/RPC9_sf.
DR InterPro; IPR038846; RPC9.
DR PANTHER; PTHR15561; PTHR15561; 1.
DR Pfam; PF03874; RNA_pol_Rpb4; 1.
DR SMART; SM00657; RPOL4c; 1.
DR SUPFAM; SSF47819; SSF47819; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cell membrane; DNA-directed RNA polymerase; Immunity;
KW Innate immunity; Membrane; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..148
FT /note="DNA-directed RNA polymerase III subunit RPC9"
FT /id="PRO_0000079336"
FT REGION 124..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 148 AA; 16683 MW; E5E6B716A7F9AFEC CRC64;
MEVKDANAAL LSNYEVFQLL TDLKEQRKES GKNKHSAGQQ NLNAITYETL KYISKTPCRN
QSPAIVQEFL TAMKSHKLTK AEKLQLLNHR PMTAVEIQLM VEESEERLTE EQIEALLHTV
TSILPAGPED EQSKSTSNDV AMEEEEPA
