RPC9_SCHPO
ID RPC9_SCHPO Reviewed; 129 AA.
AC Q9C0Z9;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=DNA-directed RNA polymerase III subunit rpc9;
DE Short=RNA polymerase III subunit C9;
DE AltName: Full=RNA polymerase III subunit C17;
GN Name=rpc17; ORFNames=SPAPB1E7.10;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=972 / ATCC 24843;
RX PubMed=16877568; DOI=10.1093/nar/gkl421;
RA Proshkina G.M., Shematorova E.K., Proshkin S.A., Zaros C., Thuriaux P.,
RA Shpakovski G.V.;
RT "Ancient origin, functional conservation and fast evolution of DNA-
RT dependent RNA polymerase III.";
RL Nucleic Acids Res. 34:3615-3624(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific peripheric component of RNA polymerase III which synthesizes
CC small RNAs, such as 5S rRNA and tRNAs. {ECO:0000269|PubMed:16877568}.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC9 RNA polymerase subunit
CC family. {ECO:0000305}.
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DR EMBL; DQ156220; ABA54848.1; -; mRNA.
DR EMBL; CU329670; CAC36927.1; -; Genomic_DNA.
DR RefSeq; NP_594136.1; NM_001019560.2.
DR PDB; 3AYH; X-ray; 2.19 A; A=1-129.
DR PDBsum; 3AYH; -.
DR AlphaFoldDB; Q9C0Z9; -.
DR SMR; Q9C0Z9; -.
DR BioGRID; 280067; 4.
DR STRING; 4896.SPAPB1E7.10.1; -.
DR MaxQB; Q9C0Z9; -.
DR PaxDb; Q9C0Z9; -.
DR EnsemblFungi; SPAPB1E7.10.1; SPAPB1E7.10.1:pep; SPAPB1E7.10.
DR GeneID; 2543653; -.
DR KEGG; spo:SPAPB1E7.10; -.
DR PomBase; SPAPB1E7.10; rpc17.
DR VEuPathDB; FungiDB:SPAPB1E7.10; -.
DR eggNOG; KOG4168; Eukaryota.
DR HOGENOM; CLU_092529_3_1_1; -.
DR InParanoid; Q9C0Z9; -.
DR OMA; VMIINLR; -.
DR PhylomeDB; Q9C0Z9; -.
DR Reactome; R-SPO-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-SPO-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR PRO; PR:Q9C0Z9; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005666; C:RNA polymerase III complex; IGI:PomBase.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IGI:PomBase.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IGI:PomBase.
DR Gene3D; 1.20.1250.40; -; 1.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR006590; RNA_pol_Rpb4/RPC9_core.
DR InterPro; IPR005574; Rpb4/RPC9.
DR InterPro; IPR038324; Rpb4/RPC9_sf.
DR InterPro; IPR038846; RPC9.
DR PANTHER; PTHR15561; PTHR15561; 1.
DR Pfam; PF03874; RNA_pol_Rpb4; 1.
DR SMART; SM00657; RPOL4c; 1.
DR SUPFAM; SSF47819; SSF47819; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA-directed RNA polymerase; Nucleus;
KW Reference proteome; Transcription.
FT CHAIN 1..129
FT /note="DNA-directed RNA polymerase III subunit rpc9"
FT /id="PRO_0000352805"
FT STRAND 2..11
FT /evidence="ECO:0007829|PDB:3AYH"
FT HELIX 13..34
FT /evidence="ECO:0007829|PDB:3AYH"
FT HELIX 35..38
FT /evidence="ECO:0007829|PDB:3AYH"
FT HELIX 43..57
FT /evidence="ECO:0007829|PDB:3AYH"
FT TURN 58..60
FT /evidence="ECO:0007829|PDB:3AYH"
FT HELIX 67..75
FT /evidence="ECO:0007829|PDB:3AYH"
FT TURN 76..80
FT /evidence="ECO:0007829|PDB:3AYH"
FT HELIX 84..93
FT /evidence="ECO:0007829|PDB:3AYH"
FT HELIX 98..104
FT /evidence="ECO:0007829|PDB:3AYH"
FT HELIX 108..112
FT /evidence="ECO:0007829|PDB:3AYH"
FT TURN 113..116
FT /evidence="ECO:0007829|PDB:3AYH"
FT HELIX 117..127
FT /evidence="ECO:0007829|PDB:3AYH"
SQ SEQUENCE 129 AA; 14927 MW; E51BA8A9525EC2BA CRC64;
MKVLEARDAY LTNAEVFFHL KEMENEQNAR TQERGAAQAL VCENLRTIQF EILKYLSSQG
NCEGLTKERF LDCIAIFNEF ELTKAEILVI LNNKPSSVPE LYACIEGIEE RFKEEDIFKL
VEKINTTFP
