ID   RPCH_CALSI              Reviewed;         109 AA.
AC   Q23757;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Red pigment-concentrating prohormone;
DE   Contains:
DE     RecName: Full=Red pigment-concentrating hormone;
DE              Short=RPCH;
DE   Contains:
DE     RecName: Full=RPCH-related peptide;
DE   Flags: Precursor;
OS   Callinectes sapidus (Blue crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC   Eubrachyura; Portunoidea; Portunidae; Callinectes.
OX   NCBI_TaxID=6763;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=7611999; DOI=10.1006/bbrc.1995.1949;
RA   Klein J.M., Mohrherr C.J., Sleutels F., Jaenecke N., Riehm J.P., Rao K.R.;
RT   "A highly conserved red pigment-concentrating hormone precursor in the blue
RT   crab Callinectes sapidus.";
RL   Biochem. Biophys. Res. Commun. 212:151-158(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Martinez F., Valdez J., Zinker S., Arechiga H.;
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This hormone adapts the animal to light backgrounds by
CC       stimulating concentration of the pigment of its red body-
CC       chromatophores.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   EMBL; L36824; AAC37244.1; -; mRNA.
DR   EMBL; AF031654; AAF21244.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q23757; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0031409; F:pigment binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   InterPro; IPR010475; AKH/RPCH_hormone.
DR   Pfam; PF06377; Adipokin_hormo; 1.
DR   PROSITE; PS00256; AKH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Pigment;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..109
FT                   /note="Red pigment-concentrating prohormone"
FT                   /id="PRO_0000000934"
FT   PEPTIDE         26..33
FT                   /note="Red pigment-concentrating hormone"
FT                   /id="PRO_0000000935"
FT   CHAIN           37..109
FT                   /note="RPCH-related peptide"
FT                   /id="PRO_0000000936"
FT   REGION          34..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         26
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         33
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   109 AA;  10929 MW;  6639AEC16AF4A661 CRC64;
     MVRRSGVTLL VVALLVVTLM SSVSAQLNFS PGWGKRAAGA SGSNGGVGEA VSGLHPSVGG
     APGGVVPPGS SSPGDSCGPI PVSAVMHIYR LIRSEAVRLV QCQDEEYLG