ID   RPCH_CARMA              Reviewed;         110 AA.
AC   Q26324;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Red pigment-concentrating prohormone;
DE   Contains:
DE     RecName: Full=Red pigment-concentrating hormone;
DE              Short=RPCH;
DE   Contains:
DE     RecName: Full=RPCH-related peptide;
DE   Flags: Precursor;
OS   Carcinus maenas (Common shore crab) (Green crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC   Eubrachyura; Portunoidea; Carcinidae; Carcinus.
OX   NCBI_TaxID=6759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=8373416; DOI=10.1006/bbrc.1993.2117;
RA   Linck B., Klein J.M., Mangerich S., Keller R., Weidemann W.M.;
RT   "Molecular cloning of crustacean red pigment concentrating hormone
RT   precursor.";
RL   Biochem. Biophys. Res. Commun. 195:807-813(1993).
CC   -!- FUNCTION: This hormone adapts the animal to light backgrounds by
CC       stimulating concentration of the pigment of its red body-
CC       chromatophores.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; S65357; AAB28133.1; -; mRNA.
DR   PIR; JN0761; JN0761.
DR   AlphaFoldDB; Q26324; -.
DR   SMR; Q26324; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0031409; F:pigment binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   InterPro; IPR010475; AKH/RPCH_hormone.
DR   Pfam; PF06377; Adipokin_hormo; 1.
DR   PROSITE; PS00256; AKH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Pigment;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..110
FT                   /note="Red pigment-concentrating prohormone"
FT                   /id="PRO_0000000937"
FT   PEPTIDE         26..33
FT                   /note="Red pigment-concentrating hormone"
FT                   /id="PRO_0000000938"
FT   CHAIN           37..110
FT                   /note="RPCH-related peptide"
FT                   /id="PRO_0000000939"
FT   MOD_RES         26
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         33
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   110 AA;  10998 MW;  1D4DF64526F8B704 CRC64;
     MVRRTGVTLL VVALVVVALV SSVSAQLNFS PGWGKRAAAG SGSSGGVGEA VSALHHSVGG
     APGGVVPPGS SSSSGDSCGP IPVSAVMHIY RLIRNEAVRL VQCQDEEYLG