ID   RPCH_PENMO              Reviewed;          93 AA.
AC   B3EWG0; W0K8U8;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   18-JUL-2018, sequence version 2.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Red pigment-concentrating hormone {ECO:0000303|PubMed:24937259};
DE            Short=PmRPCH {ECO:0000303|PubMed:24937259};
DE            Short=RPCH {ECO:0000303|PubMed:24937259};
DE   Flags: Precursor;
OS   Penaeus monodon (Giant tiger prawn).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=6687;
RN   [1] {ECO:0000312|EMBL:AHG06296.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   INDUCTION BY HYPERSALINITY.
RC   TISSUE=Eyestalk {ECO:0000303|PubMed:24937259};
RX   PubMed=24937259; DOI=10.1016/j.cbpa.2014.06.001;
RA   Sathapondecha P., Panyim S., Udomkit A.;
RT   "Molecular characterization of a cDNA encoding red pigment-concentrating
RT   hormone in black tiger shrimp Penaeus monodon: Implication of its function
RT   in molt and osmoregulation.";
RL   Comp. Biochem. Physiol. 175:124-130(2014).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 22-29, PYROGLUTAMATE FORMATION AT GLN-22, AND AMIDATION
RP   AT TRP-29.
RC   TISSUE=CNS {ECO:0000269|Ref.2};
RA   Chansela P., Kornthong N., Hanna P., Setou M., Sobhon P.;
RT   "Identification of Red pigment Concentrating Hormone in CNS of Penaeus
RT   monodon.";
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: This hormone adapts the animal to light backgrounds by
CC       stimulating concentration of the pigment of its red body-
CC       chromatophores. {ECO:0000250|UniProtKB:P08939}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P08939}.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in the eyestalk and weakly in
CC       brain. Not expressed in other tissues tested.
CC       {ECO:0000269|PubMed:24937259}.
CC   -!- DEVELOPMENTAL STAGE: Expression changes during the molting cycle with
CC       highest expression in the late pre-molt and post-molt stages,
CC       intermediate expression in the intermolt stage and lowest expression in
CC       the early pre-molt stage. {ECO:0000269|PubMed:24937259}.
CC   -!- INDUCTION: Temporarily up-regulated under high salt conditions.
CC       {ECO:0000269|PubMed:24937259}.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000255}.
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DR   EMBL; KC757347; AHG06296.1; -; mRNA.
DR   AlphaFoldDB; B3EWG0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0031409; F:pigment binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   InterPro; IPR010475; AKH/RPCH_hormone.
DR   Pfam; PF06377; Adipokin_hormo; 1.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Pigment; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|Ref.2"
FT   PEPTIDE         22..29
FT                   /note="Red pigment-concentrating hormone"
FT                   /evidence="ECO:0000269|Ref.2"
FT                   /id="PRO_0000416054"
FT   PROPEP          33..93
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444750"
FT   REGION          34..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         22
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|Ref.2"
FT   MOD_RES         29
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|Ref.2"
SQ   SEQUENCE   93 AA;  9589 MW;  22CE4E6E6286117E CRC64;
     MVRAVVATLL VVLVVASCVS AQLNFSPGWG KRAAAGGEGT GMHPPAGAVV PPPSSLAGES
     CGTIPVTTVM HIYRLIRAEA TRLVQCQDEE YLG