ID   RPD1_ARATH              Reviewed;         409 AA.
AC   Q689D6; Q8GWI6;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Protein ROOT PRIMORDIUM DEFECTIVE 1;
GN   Name=RPD1; OrderedLocusNames=At4g33495; ORFNames=F17M5;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DISRUPTION
RP   PHENOTYPE, AND MUTAGENESIS OF ARG-152 AND GLU-308.
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=16407439; DOI=10.1104/pp.105.074724;
RA   Konishi M., Sugiyama M.;
RT   "A novel plant-specific family gene, ROOT PRIMORDIUM DEFECTIVE 1, is
RT   required for the maintenance of active cell proliferation.";
RL   Plant Physiol. 140:591-602(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-409.
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [5]
RP   MUTANT RPD1.
RX   PubMed=14522871; DOI=10.1242/dev.00794;
RA   Konishi M., Sugiyama M.;
RT   "Genetic analysis of adventitious root formation with a novel series of
RT   temperature-sensitive mutants of Arabidopsis thaliana.";
RL   Development 130:5637-5647(2003).
CC   -!- FUNCTION: Involved in pre-arranging the maintenance of the active cell
CC       proliferation during root primordium development. Does not seem to be
CC       involved in cell cycle progression. {ECO:0000269|PubMed:16407439}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, hypocotyls, cotyledons and
CC       shoot apex. {ECO:0000269|PubMed:16407439}.
CC   -!- DISRUPTION PHENOTYPE: Embryo lethal when homozygous.
CC       {ECO:0000269|PubMed:16407439}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC43408.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB189464; BAD42412.1; -; mRNA.
DR   EMBL; AL035678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002687; AEE86235.1; -; Genomic_DNA.
DR   EMBL; AK118818; BAC43408.1; ALT_INIT; mRNA.
DR   RefSeq; NP_680759.1; NM_148393.3.
DR   AlphaFoldDB; Q689D6; -.
DR   SMR; Q689D6; -.
DR   STRING; 3702.AT4G33495.1; -.
DR   PaxDb; Q689D6; -.
DR   PRIDE; Q689D6; -.
DR   ProteomicsDB; 227956; -.
DR   EnsemblPlants; AT4G33495.1; AT4G33495.1; AT4G33495.
DR   GeneID; 829487; -.
DR   Gramene; AT4G33495.1; AT4G33495.1; AT4G33495.
DR   KEGG; ath:AT4G33495; -.
DR   Araport; AT4G33495; -.
DR   TAIR; locus:504955534; AT4G33495.
DR   eggNOG; ENOG502QVHJ; Eukaryota.
DR   HOGENOM; CLU_024287_0_1_1; -.
DR   InParanoid; Q689D6; -.
DR   OMA; CAIEKLR; -.
DR   OrthoDB; 515724at2759; -.
DR   PhylomeDB; Q689D6; -.
DR   PRO; PR:Q689D6; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q689D6; baseline and differential.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0010102; P:lateral root morphogenesis; IMP:TAIR.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:TAIR.
DR   InterPro; IPR021099; PORR_domain.
DR   InterPro; IPR045040; PORR_fam.
DR   InterPro; IPR040295; RPD1-like.
DR   PANTHER; PTHR31476; PTHR31476; 1.
DR   PANTHER; PTHR31476:SF9; PTHR31476:SF9; 1.
DR   Pfam; PF11955; PORR; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..409
FT                   /note="Protein ROOT PRIMORDIUM DEFECTIVE 1"
FT                   /id="PRO_0000423019"
FT   DOMAIN          47..386
FT                   /note="PORR"
FT                   /evidence="ECO:0000255"
FT   MUTAGEN         152
FT                   /note="R->W: In rpd1-2; impaired in adventitious root
FT                   formation at the restrictive temperature of 28 degrees
FT                   Celsius."
FT                   /evidence="ECO:0000269|PubMed:16407439"
FT   MUTAGEN         308
FT                   /note="E->K: In rpd1-1; impaired in adventitious root
FT                   formation and maintenance of callus cell proliferation at
FT                   the restrictive temperature of 28 degrees Celsius."
FT                   /evidence="ECO:0000269|PubMed:16407439"
FT   CONFLICT        236
FT                   /note="D -> G (in Ref. 4; BAC43408)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   409 AA;  48286 MW;  AB398ED62BD6E3FA CRC64;
     MKLFLRNAFK TLNPKRKLAT TILPSINLIL VKPFSQSTTI PKKQDRVRDH GYDNYMEVEK
     KIRKVVKFHS LILSQPNHTI AISLLDTLAR RLGLGFKQHE PGAFLLKFPH VFEIYEHPVQ
     RILYCRLTRK ALDQIRHEHE AVLDQIPDAV TRLRKLVMMS NTGRIRLEHV RIARTEFGLP
     EDFEYSVILK HPQFFRLIDG EETRDKYIEI VEKDPNLSIC AIERVREIEY RTKGIDAEDV
     RFSFVVNFPP GFKIGKYFRI AVWKWQRLPY WSPYEDISGY DLRSMEAQNR LEKRSVACIH
     ELLSLTVEKK ITLERIAHFR NVMNLPKKLK EFLLQHQGIF YISTRGNYGK LHTVFLREGY
     KRGELVEPND VYLARRRLAE LVLMSPRKAK VDAELVRYRD GLDDEDDVE