AB2D_ARATH
ID AB2D_ARATH Reviewed; 706 AA.
AC Q6NLC1; Q9SLJ9;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=ABC transporter D family member 2, chloroplastic;
DE Short=ABC transporter ABCD.2;
DE Short=AtABCD2;
DE EC=7.-.-.-;
DE Flags: Precursor;
GN Name=ABCC2; Synonyms=PMP1; OrderedLocusNames=At1g54350; ORFNames=F20D21.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PROTEIN SEQUENCE OF 45-57, ACETYLATION AT SER-45, IDENTIFICATION BY MASS
RP SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=18431481; DOI=10.1371/journal.pone.0001994;
RA Zybailov B., Rutschow H., Friso G., Rudella A., Emanuelsson O., Sun Q.,
RA van Wijk K.J.;
RT "Sorting signals, N-terminal modifications and abundance of the chloroplast
RT proteome.";
RL PLoS ONE 3:E1994-E1994(2008).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [6]
RP GENE FAMILY.
RX PubMed=11855639; DOI=10.1007/s004250100661;
RA Martinoia E., Klein M., Geisler M., Bovet L., Forestier C.,
RA Kolukisaoglu H.U., Mueller-Roeber B., Schulz B.;
RT "Multifunctionality of plant ABC transporters -- more than just
RT detoxifiers.";
RL Planta 214:345-355(2002).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBUNIT: Homodimer or heterodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC Plastid, chloroplast {ECO:0000269|PubMed:18431481}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCD family.
CC Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD25615.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005287; AAD25615.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33083.1; -; Genomic_DNA.
DR EMBL; BT012226; AAS76713.1; -; mRNA.
DR EMBL; BT012413; AAS92329.1; -; mRNA.
DR PIR; B96585; B96585.
DR RefSeq; NP_175837.2; NM_104313.4.
DR AlphaFoldDB; Q6NLC1; -.
DR SMR; Q6NLC1; -.
DR BioGRID; 27101; 15.
DR IntAct; Q6NLC1; 15.
DR STRING; 3702.AT1G54350.1; -.
DR TCDB; 3.A.1.203.8; the atp-binding cassette (abc) superfamily.
DR iPTMnet; Q6NLC1; -.
DR PaxDb; Q6NLC1; -.
DR PRIDE; Q6NLC1; -.
DR ProteomicsDB; 245094; -.
DR EnsemblPlants; AT1G54350.1; AT1G54350.1; AT1G54350.
DR GeneID; 841876; -.
DR Gramene; AT1G54350.1; AT1G54350.1; AT1G54350.
DR KEGG; ath:AT1G54350; -.
DR Araport; AT1G54350; -.
DR TAIR; locus:2020138; AT1G54350.
DR eggNOG; KOG0060; Eukaryota.
DR HOGENOM; CLU_007587_6_0_1; -.
DR OMA; FRYGLVH; -.
DR OrthoDB; 309052at2759; -.
DR PhylomeDB; Q6NLC1; -.
DR BioCyc; ARA:AT1G54350-MON; -.
DR PRO; PR:Q6NLC1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6NLC1; baseline and differential.
DR Genevisible; Q6NLC1; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005324; F:long-chain fatty acid transporter activity; IBA:GO_Central.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR GO; GO:0015910; P:long-chain fatty acid import into peroxisome; IBA:GO_Central.
DR GO; GO:0007031; P:peroxisome organization; IBA:GO_Central.
DR GO; GO:0042760; P:very long-chain fatty acid catabolic process; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF06472; ABC_membrane_2; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; ATP-binding; Chloroplast; Direct protein sequencing; Membrane;
KW Nucleotide-binding; Plastid; Reference proteome; Transit peptide;
KW Translocase; Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..44
FT /note="Chloroplast"
FT /evidence="ECO:0000269|PubMed:18431481"
FT CHAIN 45..706
FT /note="ABC transporter D family member 2, chloroplastic"
FT /id="PRO_0000379136"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 200..222
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 88..372
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 430..697
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 545..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 464..471
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT MOD_RES 45
FT /note="N-acetylserine"
FT /evidence="ECO:0000269|PubMed:18431481"
SQ SEQUENCE 706 AA; 80054 MW; 4E6422F72A26F7FC CRC64;
MILMITAPVC PPHLLLRHSS LLRHESSIGN FHRKKNPRFR TVSCSSLLPQ PSVRPDKASE
LKTLWKKFYK VASPYWFSED KDQARLRLAA VFALTLATTG ISVGFNFLGR DFYNSLANKD
QEQFTKQLFY YLCAFAGGIP FFVLRDYTKE TLSLRWRSWM TKYYLQRYLK DQTFYKIQSQ
SIIDNPDQRL VDDLSSFTGT ALSFSLTLVN ATIDLISFSN ILFTIYPPLF LVLLLYSFGG
TAISVFLGKG LVNLNFLQEK KEADFRYSLV RVRENAESIA FYGGEQNEMQ LLLQRFRSAF
DNLTELLIAS RNLEFFTDGY RYLIQILPVA VVAPMYFSGK IEFGVINQSV SAFNHILGDF
SLVVYQFQAI SSFSAVIDRL GEFDDLLDNN IFRDPSDTVD EIELTYQSEM NSSLLDTNGS
IKSQPNQKRL EIEELTLQTP TNGTTLVHNL SADVYDKDHL LIMGPSGSGK TSLLRAMAGL
WRSGKGKITF YLDPEVDFTQ EKSDTQENSG KRGDVLFLPQ RPYMVLGSLR QQLLYPTWSA
TVEETTPGGS NIDGSPPLLI REDGNEKPTT DDLMRTLEKV CLGHIADRFG GLDSIHEWSS
VLSLGEQQRL AFARLLLSQP KLALLDESTS ALDEANEAFL YQQIQSAGIT YISIGHRRTL
TKFHNKILQI STADPKSNER NWRIEDVDAQ DSLYGRLNQK EVPSES
