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RPF1_CORGL
ID   RPF1_CORGL              Reviewed;         193 AA.
AC   Q6M6W5; Q8NS60;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Resuscitation-promoting factor Rpf1;
DE            EC=3.-.-.-;
DE   Flags: Precursor;
GN   Name=rpf1; OrderedLocusNames=Cgl0819, cg0936;
OS   Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS   JCM 1318 / LMG 3730 / NCIMB 10025).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196627;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA   Ikeda M., Nakagawa S.;
RT   "The Corynebacterium glutamicum genome: features and impacts on
RT   biotechnological processes.";
RL   Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12948626; DOI=10.1016/s0168-1656(03)00154-8;
RA   Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A.,
RA   Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A.,
RA   Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F.,
RA   Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O.,
RA   Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
RT   "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its
RT   impact on the production of L-aspartate-derived amino acids and vitamins.";
RL   J. Biotechnol. 104:5-25(2003).
RN   [3]
RP   SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=15480574; DOI=10.1007/s00203-004-0713-1;
RA   Hartmann M., Barsch A., Niehaus K., Puhler A., Tauch A., Kalinowski J.;
RT   "The glycosylated cell surface protein Rpf2, containing a resuscitation-
RT   promoting factor motif, is involved in intercellular communication of
RT   Corynebacterium glutamicum.";
RL   Arch. Microbiol. 182:299-312(2004).
CC   -!- FUNCTION: Factor that stimulates resuscitation of dormant cells. Has
CC       peptidoglycan (PG) hydrolytic activity. Active in the pM concentration
CC       range. Has little to no effect on actively-growing cells. PG fragments
CC       could either directly activate the resuscitation pathway of dormant
CC       bacteria or serve as a substrate for endogenous Rpf, resulting in low
CC       molecular weight products with resuscitation activity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:15480574}. Note=Upon
CC       overexpression.
CC   -!- DISRUPTION PHENOTYPE: Not essential; a double rpf1-rpf2 disruption
CC       mutant is also viable. The double mutant displays a prolonged lag phase
CC       and slower growth after transfer of long-stored cells into fresh
CC       medium. {ECO:0000269|PubMed:15480574}.
CC   -!- SIMILARITY: Belongs to the transglycosylase family. Rpf subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB98212.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BA000036; BAB98212.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BX927150; CAF19525.1; -; Genomic_DNA.
DR   RefSeq; NP_600048.1; NC_003450.3.
DR   RefSeq; WP_003862355.1; NC_006958.1.
DR   AlphaFoldDB; Q6M6W5; -.
DR   SMR; Q6M6W5; -.
DR   STRING; 196627.cg0936; -.
DR   CAZy; GH23; Glycoside Hydrolase Family 23.
DR   KEGG; cgb:cg0936; -.
DR   KEGG; cgl:Cgl0819; -.
DR   PATRIC; fig|196627.13.peg.801; -.
DR   eggNOG; COG1652; Bacteria.
DR   HOGENOM; CLU_045108_1_0_11; -.
DR   Proteomes; UP000000582; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd13925; RPF; 1.
DR   Gene3D; 1.10.1200.100; -; 1.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR010618; RPF.
DR   InterPro; IPR021630; Rpf1_C.
DR   InterPro; IPR044905; Rpf1_C_sf.
DR   Pfam; PF11574; DUF3235; 1.
DR   Pfam; PF06737; Transglycosylas; 1.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..193
FT                   /note="Resuscitation-promoting factor Rpf1"
FT                   /id="PRO_0000421069"
SQ   SEQUENCE   193 AA;  19703 MW;  CF6807C242652A7A CRC64;
     MGRHSTKTSS AFTKLAASTI AFGAAATIMA PSASAAPDSD WDRLAQCESG GNWAINTGNG
     YHGGLQFSAS TWAAYGGQEF ATYAYQATRE QQIAVAERTL AGQGWGAWPA CSASLGLNSA
     PTQRDLSATT STPEPAAAAP AVAEYNAPAA NIAVGSTDLN TIKSTYGAVT GTLAQYGITV
     PAEVESYYNA FVG
 
 
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