ID   RPF1_DANRE              Reviewed;         330 AA.
AC   Q6IQU6;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Ribosome production factor 1;
DE   AltName: Full=Brix domain-containing protein 5;
DE   AltName: Full=Ribosome biogenesis protein RPF1;
GN   Name=rpf1; Synonyms=bxdc5; ORFNames=zgc:86604;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be required for ribosome biogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC071307; AAH71307.1; -; mRNA.
DR   AlphaFoldDB; Q6IQU6; -.
DR   SMR; Q6IQU6; -.
DR   STRING; 7955.ENSDARP00000117162; -.
DR   PaxDb; Q6IQU6; -.
DR   ZFIN; ZDB-GENE-040625-177; rpf1.
DR   eggNOG; KOG2780; Eukaryota.
DR   InParanoid; Q6IQU6; -.
DR   PhylomeDB; Q6IQU6; -.
DR   PRO; PR:Q6IQU6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0042134; F:rRNA primary transcript binding; IEA:InterPro.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR044281; IMP4/RPF1.
DR   PANTHER; PTHR22734; PTHR22734; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding;
KW   rRNA processing; rRNA-binding.
FT   CHAIN           1..330
FT                   /note="Ribosome production factor 1"
FT                   /id="PRO_0000120252"
FT   DOMAIN          123..306
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          53..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          284..301
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  38759 MW;  B475438E1E149D53 CRC64;
     MKAVKAPVEE MDQAECEVKE EKSASGPCFP PTFSVSEIKN KQRRHTMFLK LKEEKRKKRM
     ELKKKKKKER KALDDKAPPK EVPKTIENQR IYDETTVNPE DEEVAFDEGT DEFSAYFNRL
     TNPKVLITTS DRPRGRTVRF CDQLATVIPH AYVYYRRGLA LKKVIPQCIS RGFTYLMVIN
     EDRKVPNGMV LCHLPDGPTA HFKVSSVRLR KEMKRRGKNP TEHSPEVILN NFTTRLGHSI
     GRLFAALFPH DPQFVGRQVA TFHNQRDFIF FRFHRYIFKN EKKVGIQELG PRFTLKLRSL
     QKGTFDSKFG EYEWVHKRHE MDSSRRKFHL