RPF1_MOUSE
ID RPF1_MOUSE Reviewed; 349 AA.
AC Q7TND5; Q3TBS4; Q5EBN9; Q8K343;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Ribosome production factor 1;
DE AltName: Full=Brix domain-containing protein 5;
DE AltName: Full=Ribosome biogenesis protein RPF1;
GN Name=Rpf1; Synonyms=Bxdc5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Dendritic cell;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, Eye, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be required for ribosome biogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH28802.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=AAH56165.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH89369.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK171079; BAE42233.1; -; mRNA.
DR EMBL; BC028802; AAH28802.1; ALT_SEQ; mRNA.
DR EMBL; BC056165; AAH56165.2; ALT_INIT; mRNA.
DR EMBL; BC089369; AAH89369.2; ALT_INIT; mRNA.
DR CCDS; CCDS51089.1; -.
DR RefSeq; NP_081608.1; NM_027332.3.
DR RefSeq; NP_081647.2; NM_027371.3.
DR AlphaFoldDB; Q7TND5; -.
DR SMR; Q7TND5; -.
DR BioGRID; 213961; 1.
DR IntAct; Q7TND5; 1.
DR MINT; Q7TND5; -.
DR STRING; 10090.ENSMUSP00000029838; -.
DR iPTMnet; Q7TND5; -.
DR PhosphoSitePlus; Q7TND5; -.
DR EPD; Q7TND5; -.
DR MaxQB; Q7TND5; -.
DR PaxDb; Q7TND5; -.
DR PeptideAtlas; Q7TND5; -.
DR PRIDE; Q7TND5; -.
DR ProteomicsDB; 260925; -.
DR Antibodypedia; 19767; 42 antibodies from 18 providers.
DR DNASU; 70285; -.
DR Ensembl; ENSMUST00000029838; ENSMUSP00000029838; ENSMUSG00000028187.
DR GeneID; 70285; -.
DR KEGG; mmu:70285; -.
DR UCSC; uc008rrl.2; mouse.
DR CTD; 80135; -.
DR MGI; MGI:1917535; Rpf1.
DR VEuPathDB; HostDB:ENSMUSG00000028187; -.
DR eggNOG; KOG2780; Eukaryota.
DR GeneTree; ENSGT00940000153231; -.
DR HOGENOM; CLU_040063_1_0_1; -.
DR InParanoid; Q7TND5; -.
DR OMA; WIISNKR; -.
DR OrthoDB; 768872at2759; -.
DR PhylomeDB; Q7TND5; -.
DR TreeFam; TF105897; -.
DR BioGRID-ORCS; 70285; 18 hits in 71 CRISPR screens.
DR ChiTaRS; Rpf1; mouse.
DR PRO; PR:Q7TND5; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q7TND5; protein.
DR Bgee; ENSMUSG00000028187; Expressed in embryonic post-anal tail and 253 other tissues.
DR ExpressionAtlas; Q7TND5; baseline and differential.
DR Genevisible; Q7TND5; MM.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0042134; F:rRNA primary transcript binding; IEA:InterPro.
DR GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR InterPro; IPR007109; Brix.
DR InterPro; IPR044281; IMP4/RPF1.
DR PANTHER; PTHR22734; PTHR22734; 1.
DR Pfam; PF04427; Brix; 1.
DR SMART; SM00879; Brix; 1.
DR PROSITE; PS50833; BRIX; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding;
KW rRNA processing; rRNA-binding.
FT CHAIN 1..349
FT /note="Ribosome production factor 1"
FT /id="PRO_0000120249"
FT DOMAIN 142..325
FT /note="Brix"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..320
FT /note="RNA-binding"
FT /evidence="ECO:0000250"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 47
FT /note="A -> V (in Ref. 1; BAE42233)"
FT /evidence="ECO:0000305"
FT CONFLICT 299
FT /note="S -> G (in Ref. 1; BAE42233)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 349 AA; 40037 MW; 9E044A2C04E32F77 CRC64;
MAKAGEKSVG GGKRGLKRKA AAEEPQEAAA ASDGTAESGV QPAKAAAFPP GFSISEIKNK
QRRHLMFTRW KQQQRKEKLA AKKKLKKERE ALGDKAPPKP VPKTIDNQRV YDETTVDPND
EEVAYDEATD EFASYFNRQT SPKILITTSD RPHGRTVRLC EQLSTVIPDS HVYYRRGLAL
KKIIPQCIAR DFTDLIVINE DRKTPNGLIL SHLPNGPTAH FKMSSVRLRK EIKRRGKDPT
EHVPEIILNN FTTRLGHSIG RMFASLFPHN PQFIGRQVAT FHNQRDYIFF RFHRYIFKSE
KKVGIQELGP RFTLKLRSLQ KGTFDSKYGE YEWVHKPREM DTSRRKFHL
