ID   RPF1_PONAB              Reviewed;         349 AA.
AC   Q5R631;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Ribosome production factor 1;
DE   AltName: Full=Brix domain-containing protein 5;
DE   AltName: Full=Ribosome biogenesis protein RPF1;
GN   Name=RPF1; Synonyms=BXDC5;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be required for ribosome biogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
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DR   EMBL; CR860667; CAH92785.1; -; mRNA.
DR   RefSeq; NP_001126626.1; NM_001133154.1.
DR   AlphaFoldDB; Q5R631; -.
DR   SMR; Q5R631; -.
DR   STRING; 9601.ENSPPYP00000001396; -.
DR   Ensembl; ENSPPYT00000001441; ENSPPYP00000001396; ENSPPYG00000001206.
DR   GeneID; 100173623; -.
DR   KEGG; pon:100173623; -.
DR   CTD; 80135; -.
DR   eggNOG; KOG2780; Eukaryota.
DR   GeneTree; ENSGT00940000153231; -.
DR   HOGENOM; CLU_040063_1_0_1; -.
DR   InParanoid; Q5R631; -.
DR   OrthoDB; 768872at2759; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0042134; F:rRNA primary transcript binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR044281; IMP4/RPF1.
DR   PANTHER; PTHR22734; PTHR22734; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding;
KW   rRNA processing; rRNA-binding.
FT   CHAIN           1..349
FT                   /note="Ribosome production factor 1"
FT                   /id="PRO_0000120250"
FT   DOMAIN          142..325
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT   REGION          1..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..320
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        10..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..75
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   349 AA;  40127 MW;  DFAE8271971E14B7 CRC64;
     MAKAGDKSSS SGKKSLKRKA AAEELQEAAG AGDVATESGV QPPKAAAFPP GFSISEIKNK
     ERRHLMFTRW KQQQRKEKLA AKKKLKKERE ALGDKAPPKP VPKTIDNQRV YDETTVDPND
     EEVAYDEATD EFASYFNKQT SPKILITTSD RPHGRTVRLC EQLSTVIPNS HVYYRRGLAL
     KKIIPQCIAR DFTDLIVINE DRKTPNGLIL SHLPNGPTAH FKMSSVRLRK EIKRRGKDPT
     EHIPEIILNN FTTRLGHSIG RMFASLFPHN PQFIGRQVAT FHNQRDYIFF RFHRYIFRSE
     KKVGIQELGP RFTLKLRSLQ KGTFDSKYGE YEWVHKPREM DTSRRKFHL