ID   RPF2_BOVIN              Reviewed;         306 AA.
AC   Q2YDN6;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Ribosome production factor 2 homolog;
DE   AltName: Full=Brix domain-containing protein 1;
DE   AltName: Full=Ribosome biogenesis protein RPF2 homolog;
GN   Name=RPF2; Synonyms=BXDC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in ribosomal large subunit assembly. May regulate
CC       the localization of the 5S RNP/5S ribonucleoprotein particle to the
CC       nucleolus. {ECO:0000250|UniProtKB:Q9H7B2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9H7B2}. Note=Associated with the nucleolus in
CC       an RNA-dependent manner. {ECO:0000250|UniProtKB:Q9H7B2}.
CC   -!- SIMILARITY: Belongs to the RPF2 family. {ECO:0000305}.
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DR   EMBL; BC110138; AAI10139.1; -; mRNA.
DR   RefSeq; NP_001039548.1; NM_001046083.2.
DR   AlphaFoldDB; Q2YDN6; -.
DR   SMR; Q2YDN6; -.
DR   STRING; 9913.ENSBTAP00000022060; -.
DR   PaxDb; Q2YDN6; -.
DR   PRIDE; Q2YDN6; -.
DR   GeneID; 511294; -.
DR   KEGG; bta:511294; -.
DR   CTD; 84154; -.
DR   eggNOG; KOG3031; Eukaryota.
DR   InParanoid; Q2YDN6; -.
DR   OrthoDB; 974865at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0008097; F:5S rRNA binding; ISS:UniProtKB.
DR   GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:1902570; P:protein localization to nucleolus; ISS:UniProtKB.
DR   GO; GO:1901796; P:regulation of signal transduction by p53 class mediator; ISS:UniProtKB.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR039770; Rpf2.
DR   PANTHER; PTHR12728; PTHR12728; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..306
FT                   /note="Ribosome production factor 2 homolog"
FT                   /id="PRO_0000269722"
FT   DOMAIN          31..234
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT   REGION          268..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..306
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   306 AA;  35543 MW;  54B0E2EA8147BC26 CRC64;
     MDALDRVVKP KTKRAKRFLE KREPKLSENI KNAMLIKGGN ANSTVTQVLR DVYALKKPYG
     ILYKKKNITR PFEDQTSLEF FSKKSDCSLF MFGSHNKKRP NNLVIGRMYD YHVLDIIELG
     IEKFVSLKDI KNSKCPEGTK PMLIFAGDDF DVTEDYRRLK SLLIDFFRGP TVSNIRLAGL
     EYVLHFTALN GKIYFRSYKL LLKKSGCRTP RIELEEMGPS LDLVLRRTHL ASDDLYKLSM
     KMPKALKPKK KKNISHDTFG TTYGRIHMQK QDLSKLQTRK MKGLKKRPAE RKAEDEENKS
     KRIKKN