RPF2_SCHPO
ID RPF2_SCHPO Reviewed; 317 AA.
AC Q9UUG1; Q9UU08;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Ribosome production factor 2 homolog;
DE AltName: Full=Brix domain-containing protein 1 homolog;
DE AltName: Full=Ribosome biogenesis protein RPF2 homolog;
GN ORFNames=SPAC926.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 100-278, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293; SER-300; SER-313 AND
RP SER-316, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10759889}.
CC -!- SIMILARITY: Belongs to the RPF2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA87188.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CU329670; CAB54156.1; -; Genomic_DNA.
DR EMBL; AB027884; BAA87188.1; ALT_FRAME; Genomic_DNA.
DR PIR; T39206; T39206.
DR RefSeq; NP_594369.1; NM_001019790.2.
DR AlphaFoldDB; Q9UUG1; -.
DR SMR; Q9UUG1; -.
DR BioGRID; 279918; 13.
DR STRING; 4896.SPAC926.08c.1; -.
DR iPTMnet; Q9UUG1; -.
DR MaxQB; Q9UUG1; -.
DR PaxDb; Q9UUG1; -.
DR PRIDE; Q9UUG1; -.
DR EnsemblFungi; SPAC926.08c.1; SPAC926.08c.1:pep; SPAC926.08c.
DR GeneID; 2543500; -.
DR KEGG; spo:SPAC926.08c; -.
DR PomBase; SPAC926.08c; -.
DR VEuPathDB; FungiDB:SPAC926.08c; -.
DR eggNOG; KOG3031; Eukaryota.
DR HOGENOM; CLU_049783_0_0_1; -.
DR InParanoid; Q9UUG1; -.
DR OMA; GCKIPRI; -.
DR PhylomeDB; Q9UUG1; -.
DR PRO; PR:Q9UUG1; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISS:PomBase.
DR GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR GO; GO:1902626; P:assembly of large subunit precursor of preribosome; ISS:PomBase.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IPI:PomBase.
DR InterPro; IPR007109; Brix.
DR InterPro; IPR039770; Rpf2.
DR PANTHER; PTHR12728; PTHR12728; 1.
DR Pfam; PF04427; Brix; 1.
DR SMART; SM00879; Brix; 1.
DR PROSITE; PS50833; BRIX; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..317
FT /note="Ribosome production factor 2 homolog"
FT /id="PRO_0000120229"
FT DOMAIN 28..240
FT /note="Brix"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT REGION 287..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..317
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 293
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 300
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 313
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 316
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 317 AA; 36071 MW; 0438CA22A431DCF2 CRC64;
MLRQVKPKNA RTKRALEKRE PKLVEGAKTA IFLRGNATSQ ISLDVLGDIH ALKKPFSVNF
QKKNNILPFE DASSLEFFSE KNDAALAVMA THNKKRPHNL TWVRFFNYRV LDMIELGIVN
YKSIQSFSAT PIVPGTKPMI LFQGPVFDAH PTYRHIKSLF LDFFRGEPIQ KLDSAGLSYV
IVVSAAEAQE DETKPLPLVH FRVYGTKLLK TKTNLPRVEL EEMGPRIDFN IRRVQPAESD
VLEEALKKPK TQEPKPKKNV DVDIIGNKVG RIHVDQQDLG NLQTRKMKGL KRSVEEREDS
ENEEVEIEED VISDASE
