ID   RPFA_MYCTO              Reviewed;         407 AA.
AC   P9WG30; F2GIY6; L0T504; O53879; Q7D947;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Resuscitation-promoting factor RpfA;
DE            EC=3.-.-.-;
DE   Flags: Precursor;
GN   Name=rpfA; OrderedLocusNames=MT0890;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Factor that stimulates resuscitation of dormant cells. Has
CC       peptidoglycan (PG) hydrolytic activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transglycosylase family. Rpf subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK45131.1; -; Genomic_DNA.
DR   PIR; C70816; C70816.
DR   RefSeq; WP_003900223.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WG30; -.
DR   SMR; P9WG30; -.
DR   CAZy; GH23; Glycoside Hydrolase Family 23.
DR   EnsemblBacteria; AAK45131; AAK45131; MT0890.
DR   KEGG; mtc:MT0890; -.
DR   PATRIC; fig|83331.31.peg.955; -.
DR   HOGENOM; CLU_045108_2_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:UniProt.
DR   GO; GO:0040010; P:positive regulation of growth rate; IEA:UniProt.
DR   CDD; cd13925; RPF; 1.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR010618; RPF.
DR   Pfam; PF06737; Transglycosylas; 1.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Repeat; Signal; Virulence.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..407
FT                   /note="Resuscitation-promoting factor RpfA"
FT                   /id="PRO_0000428433"
FT   REPEAT          178..185
FT                   /note="1"
FT   REPEAT          186..193
FT                   /note="2"
FT   REPEAT          218..225
FT                   /note="3"
FT   REPEAT          226..233
FT                   /note="4"
FT   REPEAT          240..247
FT                   /note="5"
FT   REPEAT          248..255
FT                   /note="6"
FT   REPEAT          274..281
FT                   /note="7"
FT   REPEAT          287..294
FT                   /note="8"
FT   REPEAT          295..302
FT                   /note="9"
FT   REPEAT          303..310
FT                   /note="10"
FT   REPEAT          311..318
FT                   /note="11"
FT   REPEAT          353..359
FT                   /note="12"
FT   REGION          142..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..359
FT                   /note="12 X 8 AA approximate repeats of A-P-A-D-L-A-P-P"
FT   REGION          271..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..197
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..253
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        295..316
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..365
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   407 AA;  39975 MW;  E0F0A22E4EA203CE CRC64;
     MSGRHRKPTT SNVSVAKIAF TGAVLGGGGI AMAAQATAAT DGEWDQVARC ESGGNWSINT
     GNGYLGGLQF TQSTWAAHGG GEFAPSAQLA SREQQIAVGE RVLATQGRGA WPVCGRGLSN
     ATPREVLPAS AAMDAPLDAA AVNGEPAPLA PPPADPAPPV ELAANDLPAP LGEPLPAAPA
     DPAPPADLAP PAPADVAPPV ELAVNDLPAP LGEPLPAAPA DPAPPADLAP PAPADLAPPA
     PADLAPPAPA DLAPPVELAV NDLPAPLGEP LPAAPAELAP PADLAPASAD LAPPAPADLA
     PPAPAELAPP APADLAPPAA VNEQTAPGDQ PATAPGGPVG LATDLELPEP DPQPADAPPP
     GDVTEAPAET PQVSNIAYTK KLWQAIRAQD VCGNDALDSL AQPYVIG