RPFC_MYCTE
ID RPFC_MYCTE Reviewed; 140 AA.
AC H8F3N4;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 1.
DT 03-AUG-2022, entry version 33.
DE RecName: Full=Resuscitation-promoting factor RpfC;
DE EC=3.-.-.-;
DE Flags: Precursor;
GN Name=rpfC; OrderedLocusNames=ERDMAN_2076;
OS Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=652616;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=22535945; DOI=10.1128/jb.00353-12;
RA Miyoshi-Akiyama T., Matsumura K., Iwai H., Funatogawa K., Kirikae T.;
RT "Complete annotated genome sequence of Mycobacterium tuberculosis Erdman.";
RL J. Bacteriol. 194:2770-2770(2012).
RN [2]
RP INDUCTION.
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=16034419; DOI=10.1038/nature03713;
RA Makinoshima H., Glickman M.S.;
RT "Regulation of Mycobacterium tuberculosis cell envelope composition and
RT virulence by intramembrane proteolysis.";
RL Nature 436:406-409(2005).
RN [3]
RP INDUCTION.
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=20545848; DOI=10.1111/j.1365-2958.2010.07232.x;
RA Sklar J.G., Makinoshima H., Schneider J.S., Glickman M.S.;
RT "M. tuberculosis intramembrane protease Rip1 controls transcription through
RT three anti-sigma factor substrates.";
RL Mol. Microbiol. 77:605-617(2010).
CC -!- FUNCTION: Factor that stimulates resuscitation of dormant cells. Has
CC peptidoglycan (PG) hydrolytic activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- INDUCTION: By the metal chelator phenanthroline via Rip1.
CC {ECO:0000269|PubMed:16034419, ECO:0000269|PubMed:20545848}.
CC -!- SIMILARITY: Belongs to the transglycosylase family. Rpf subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP012340; BAL65869.1; -; Genomic_DNA.
DR AlphaFoldDB; H8F3N4; -.
DR SMR; H8F3N4; -.
DR CAZy; GH23; Glycoside Hydrolase Family 23.
DR EnsemblBacteria; BAL65869; BAL65869; ERDMAN_2076.
DR KEGG; mtn:ERDMAN_2076; -.
DR PATRIC; fig|652616.3.peg.2109; -.
DR HOGENOM; CLU_123842_1_0_11; -.
DR Proteomes; UP000007568; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:UniProt.
DR GO; GO:0040010; P:positive regulation of growth rate; IEA:UniProt.
DR CDD; cd13925; RPF; 1.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR010618; RPF.
DR Pfam; PF06737; Transglycosylas; 1.
DR SUPFAM; SSF53955; SSF53955; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..140
FT /note="Resuscitation-promoting factor RpfC"
FT /id="PRO_0000422691"
SQ SEQUENCE 140 AA; 14293 MW; BF895000C837B5BC CRC64;
MTRIAKPLIK SAMAAGLVTA SMSLSTAVAH AGPSPNWDAV AQCESGGNWA ANTGNGKYGG
LQFKPATWAA FGGVGNPAAA SREQQIAVAN RVLAEQGLDA WPTCGAASGL PIALWSKPAQ
GIKQIINEII WAGIQASIPR