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RPFC_MYCTE
ID   RPFC_MYCTE              Reviewed;         140 AA.
AC   H8F3N4;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Resuscitation-promoting factor RpfC;
DE            EC=3.-.-.-;
DE   Flags: Precursor;
GN   Name=rpfC; OrderedLocusNames=ERDMAN_2076;
OS   Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=652616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=22535945; DOI=10.1128/jb.00353-12;
RA   Miyoshi-Akiyama T., Matsumura K., Iwai H., Funatogawa K., Kirikae T.;
RT   "Complete annotated genome sequence of Mycobacterium tuberculosis Erdman.";
RL   J. Bacteriol. 194:2770-2770(2012).
RN   [2]
RP   INDUCTION.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=16034419; DOI=10.1038/nature03713;
RA   Makinoshima H., Glickman M.S.;
RT   "Regulation of Mycobacterium tuberculosis cell envelope composition and
RT   virulence by intramembrane proteolysis.";
RL   Nature 436:406-409(2005).
RN   [3]
RP   INDUCTION.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20545848; DOI=10.1111/j.1365-2958.2010.07232.x;
RA   Sklar J.G., Makinoshima H., Schneider J.S., Glickman M.S.;
RT   "M. tuberculosis intramembrane protease Rip1 controls transcription through
RT   three anti-sigma factor substrates.";
RL   Mol. Microbiol. 77:605-617(2010).
CC   -!- FUNCTION: Factor that stimulates resuscitation of dormant cells. Has
CC       peptidoglycan (PG) hydrolytic activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- INDUCTION: By the metal chelator phenanthroline via Rip1.
CC       {ECO:0000269|PubMed:16034419, ECO:0000269|PubMed:20545848}.
CC   -!- SIMILARITY: Belongs to the transglycosylase family. Rpf subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AP012340; BAL65869.1; -; Genomic_DNA.
DR   AlphaFoldDB; H8F3N4; -.
DR   SMR; H8F3N4; -.
DR   CAZy; GH23; Glycoside Hydrolase Family 23.
DR   EnsemblBacteria; BAL65869; BAL65869; ERDMAN_2076.
DR   KEGG; mtn:ERDMAN_2076; -.
DR   PATRIC; fig|652616.3.peg.2109; -.
DR   HOGENOM; CLU_123842_1_0_11; -.
DR   Proteomes; UP000007568; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:UniProt.
DR   GO; GO:0040010; P:positive regulation of growth rate; IEA:UniProt.
DR   CDD; cd13925; RPF; 1.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR010618; RPF.
DR   Pfam; PF06737; Transglycosylas; 1.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Secreted; Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..140
FT                   /note="Resuscitation-promoting factor RpfC"
FT                   /id="PRO_0000422691"
SQ   SEQUENCE   140 AA;  14293 MW;  BF895000C837B5BC CRC64;
     MTRIAKPLIK SAMAAGLVTA SMSLSTAVAH AGPSPNWDAV AQCESGGNWA ANTGNGKYGG
     LQFKPATWAA FGGVGNPAAA SREQQIAVAN RVLAEQGLDA WPTCGAASGL PIALWSKPAQ
     GIKQIINEII WAGIQASIPR
 
 
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