RPFD_MYCTO
ID RPFD_MYCTO Reviewed; 154 AA.
AC P9WG26; F2GI59; L0TC67; P71755; Q7D783;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 35.
DE RecName: Full=Resuscitation-promoting factor RpfD;
DE EC=3.-.-.-;
GN Name=rpfD; OrderedLocusNames=MT2458;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: Factor that stimulates resuscitation of dormant cells. Has
CC peptidoglycan (PG) hydrolytic activity. PG fragments could either
CC directly activate the resuscitation pathway of dormant bacteria or
CC serve as a substrate for endogenous Rpf, resulting in low molecular
CC weight products with resuscitation activity (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the transglycosylase family. Rpf subfamily.
CC {ECO:0000305}.
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DR EMBL; AE000516; AAK46753.1; -; Genomic_DNA.
DR PIR; H70681; H70681.
DR RefSeq; WP_003412293.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WG26; -.
DR SMR; P9WG26; -.
DR CAZy; GH23; Glycoside Hydrolase Family 23.
DR EnsemblBacteria; AAK46753; AAK46753; MT2458.
DR KEGG; mtc:MT2458; -.
DR PATRIC; fig|83331.31.peg.2649; -.
DR HOGENOM; CLU_123842_1_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:UniProt.
DR GO; GO:0040010; P:positive regulation of growth rate; IEA:UniProt.
DR CDD; cd13925; RPF; 1.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR010618; RPF.
DR Pfam; PF06737; Transglycosylas; 1.
DR SUPFAM; SSF53955; SSF53955; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Membrane; Transmembrane; Transmembrane helix;
KW Virulence.
FT CHAIN 1..154
FT /note="Resuscitation-promoting factor RpfD"
FT /id="PRO_0000428435"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 154 AA; 15679 MW; 27AFD997D193DFE7 CRC64;
MTPGLLTTAG AGRPRDRCAR IVCTVFIETA VVATMFVALL GLSTISSKAD DIDWDAIAQC
ESGGNWAANT GNGLYGGLQI SQATWDSNGG VGSPAAASPQ QQIEVADNIM KTQGPGAWPK
CSSCSQGDAP LGSLTHILTF LAAETGGCSG SRDD