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RPFD_MYCTO
ID   RPFD_MYCTO              Reviewed;         154 AA.
AC   P9WG26; F2GI59; L0TC67; P71755; Q7D783;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Resuscitation-promoting factor RpfD;
DE            EC=3.-.-.-;
GN   Name=rpfD; OrderedLocusNames=MT2458;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Factor that stimulates resuscitation of dormant cells. Has
CC       peptidoglycan (PG) hydrolytic activity. PG fragments could either
CC       directly activate the resuscitation pathway of dormant bacteria or
CC       serve as a substrate for endogenous Rpf, resulting in low molecular
CC       weight products with resuscitation activity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the transglycosylase family. Rpf subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK46753.1; -; Genomic_DNA.
DR   PIR; H70681; H70681.
DR   RefSeq; WP_003412293.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WG26; -.
DR   SMR; P9WG26; -.
DR   CAZy; GH23; Glycoside Hydrolase Family 23.
DR   EnsemblBacteria; AAK46753; AAK46753; MT2458.
DR   KEGG; mtc:MT2458; -.
DR   PATRIC; fig|83331.31.peg.2649; -.
DR   HOGENOM; CLU_123842_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:UniProt.
DR   GO; GO:0040010; P:positive regulation of growth rate; IEA:UniProt.
DR   CDD; cd13925; RPF; 1.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR010618; RPF.
DR   Pfam; PF06737; Transglycosylas; 1.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   CHAIN           1..154
FT                   /note="Resuscitation-promoting factor RpfD"
FT                   /id="PRO_0000428435"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   154 AA;  15679 MW;  27AFD997D193DFE7 CRC64;
     MTPGLLTTAG AGRPRDRCAR IVCTVFIETA VVATMFVALL GLSTISSKAD DIDWDAIAQC
     ESGGNWAANT GNGLYGGLQI SQATWDSNGG VGSPAAASPQ QQIEVADNIM KTQGPGAWPK
     CSSCSQGDAP LGSLTHILTF LAAETGGCSG SRDD
 
 
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