RPGFL_MOUSE
ID RPGFL_MOUSE Reviewed; 662 AA.
AC Q68EF8; A1L3T1;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Rap guanine nucleotide exchange factor-like 1;
GN Name=Rapgefl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probable guanine nucleotide exchange factor (GEF).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI30267.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
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DR EMBL; AL590963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466556; EDL16171.1; -; Genomic_DNA.
DR EMBL; BC080279; AAH80279.1; -; mRNA.
DR EMBL; BC130266; AAI30267.1; ALT_SEQ; mRNA.
DR CCDS; CCDS36303.1; -.
DR RefSeq; NP_001074394.1; NM_001080925.1.
DR AlphaFoldDB; Q68EF8; -.
DR SMR; Q68EF8; -.
DR BioGRID; 234506; 22.
DR STRING; 10090.ENSMUSP00000103103; -.
DR iPTMnet; Q68EF8; -.
DR PhosphoSitePlus; Q68EF8; -.
DR EPD; Q68EF8; -.
DR PaxDb; Q68EF8; -.
DR PRIDE; Q68EF8; -.
DR ProteomicsDB; 260928; -.
DR Antibodypedia; 16447; 80 antibodies from 21 providers.
DR Ensembl; ENSMUST00000107479; ENSMUSP00000103103; ENSMUSG00000038020.
DR GeneID; 268480; -.
DR KEGG; mmu:268480; -.
DR UCSC; uc007lhr.1; mouse.
DR CTD; 51195; -.
DR MGI; MGI:3611446; Rapgefl1.
DR VEuPathDB; HostDB:ENSMUSG00000038020; -.
DR eggNOG; KOG2378; Eukaryota.
DR GeneTree; ENSGT00940000160144; -.
DR HOGENOM; CLU_028002_2_0_1; -.
DR InParanoid; Q68EF8; -.
DR OMA; LQPNEDC; -.
DR OrthoDB; 143470at2759; -.
DR PhylomeDB; Q68EF8; -.
DR TreeFam; TF313184; -.
DR BioGRID-ORCS; 268480; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Rapgefl1; mouse.
DR PRO; PR:Q68EF8; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q68EF8; protein.
DR Bgee; ENSMUSG00000038020; Expressed in dentate gyrus of hippocampal formation granule cell and 82 other tissues.
DR Genevisible; Q68EF8; MM.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; -; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; PTHR23113; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; SSF48366; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor; Reference proteome.
FT CHAIN 1..662
FT /note="Rap guanine nucleotide exchange factor-like 1"
FT /id="PRO_0000349203"
FT DOMAIN 424..660
FT /note="Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT REGION 1..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 662 AA; 73695 MW; DDF5A16277585F6B CRC64;
MKPLEKFLKK QTSQLAGRAV TGGPGGGPGC CGGPGGGGGP GGGGGPAGGL RPLQRRQSVS
RLLLPAFLRE PPTEPGLEPP VEEEGGEPLG VSEEPGSGGP CWLQLEEVPG PGPIGSGVPL
RSPSSYSSDE LSPGEPLASP PWAPLGAPER PEHLLNRVLE RLAGGTTRDS SASDILLDDI
VLTHSLFLPT EKFLQELHQY FVQSRNVEGP EGLGRKQACL ALLLHFLDTY QGLLQEEEGA
GHIIKELYLL IMKDESLYQD LREDTLRLHQ LVETVELKIP EESQPPSKQV KPLFRHFRRI
DSCLQTRVAF RGSDEIFCRV YMPDHSYVTI RSRLSASVQD ILGSVTEKLQ YSEEPAERED
ALILVAVASS GEKVLLQPTE DCVFTTLGIN SHLFACTRDS YEALVPLPEE VQVSPGDTEI
HRVEPEDVAN HLTAFHWELF RCVHELEFVD YVFHGERGRR ETANLELLLQ RCSEVTHWVA
TEVLLCEAPG KRVQLLKKFI KIAAICKQNQ DLLSFYAVVM GLDNAAVSRL RLTWEKLPGK
FKNLFRKFEG LTDPCRNHKS YREVISKMKP PLIPFVPLIL KDLTFLHEGS KTLVDGLVNI
EKLHSVAEKV RTIRKYRSRP LCLDMEASPH HLQTKAYVRQ FQVIDNQNHL FELSYKLEAN
SQ
