ID   RPGFL_PONPY             Reviewed;         456 AA.
AC   Q5R9B2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Rap guanine nucleotide exchange factor-like 1;
GN   Name=RAPGEFL1;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable guanine nucleotide exchange factor (GEF).
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DR   EMBL; CR859477; CAH91648.1; -; mRNA.
DR   AlphaFoldDB; Q5R9B2; -.
DR   BMRB; Q5R9B2; -.
DR   SMR; Q5R9B2; -.
DR   PRIDE; Q5R9B2; -.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor.
FT   CHAIN           1..456
FT                   /note="Rap guanine nucleotide exchange factor-like 1"
FT                   /id="PRO_0000349204"
FT   DOMAIN          218..454
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
SQ   SEQUENCE   456 AA;  52426 MW;  031B3FC8234D98CA CRC64;
     MEGPEGLGRK QACLAMLLHF LDTYQGLLQE EEGAGHIIKD LYLLIMKDES LYQGLREDTL
     RLHQLVETVE LKIPEENQPP SKQVKPLFRH FRRIDSCLQT RVAFRGSDEI FCRVYMPDHS
     YVTIRSRLSA SVQDILGSVT EKLQYSEEPA GREDSLILVA VSSSGEKVLL QPTEDCVFTA
     LGINSHLFAC TRDSYEALVP LPEEIQVSPG DTEIHRVEPE DVANHLTAFH WELFRCVHEL
     EFVDYVFHGE RGRRETANLE LLLQRCSEVT HWVATEVLLC EAPGKRAQLL KKFIKIAALC
     KQNQDLLSFY AVVMGLDNAA VSRLRLTWEK LPGKFKNLFR KFENLTDPCR NHKSYREVIS
     KMKPPVIPFV PLILKDLTFL HEGSKTLVDG LVNIEKLHSV AEKVRTIRKY RSRPLYLDME
     ASPHHLQTKA YVRQFQVIDN QNLLFELSYK LEANSQ