ID   RPGP2_CHICK             Reviewed;         730 AA.
AC   Q5ZMV8;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Rap1 GTPase-activating protein 2;
DE            Short=Rap1GAP2;
DE   AltName: Full=GTPase-activating Rap/Ran-GAP domain-like protein 4;
GN   Name=RAP1GAP2; Synonyms=GARNL4; ORFNames=RCJMB04_1a20;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: GTPase activator for the nuclear Ras-related regulatory
CC       protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-
CC       bound state. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG30935.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ719276; CAG30935.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001026649.2; NM_001031478.2.
DR   AlphaFoldDB; Q5ZMV8; -.
DR   SMR; Q5ZMV8; -.
DR   STRING; 9031.ENSGALP00000009417; -.
DR   PaxDb; Q5ZMV8; -.
DR   GeneID; 427841; -.
DR   KEGG; gga:427841; -.
DR   CTD; 23108; -.
DR   VEuPathDB; HostDB:geneid_427841; -.
DR   eggNOG; KOG3686; Eukaryota.
DR   HOGENOM; CLU_010739_2_2_1; -.
DR   InParanoid; Q5ZMV8; -.
DR   OrthoDB; 845465at2759; -.
DR   PhylomeDB; Q5ZMV8; -.
DR   TreeFam; TF318626; -.
DR   PRO; PR:Q5ZMV8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; -; 1.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; SSF111347; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..730
FT                   /note="Rap1 GTPase-activating protein 2"
FT                   /id="PRO_0000312718"
FT   DOMAIN          247..463
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00165"
FT   REGION          510..668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          698..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..560
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        578..615
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        630..668
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   730 AA;  80792 MW;  6FA1E63BEC4A9379 CRC64;
     MFQRKRSVSF GGYGWIDKTM LASLKMKKQE LLSSADVTLP ERPLSPPLTA PPTMKSAEFF
     EMLEKMQAPK LEDQKAGSQK HKEDYIPYPS IDEILEKGSP YPLVILPQFG GYWIEDPENL
     GTPTSSDSSV CEEEEENFSP SPYGYKLECK GEARAYRKHF LGKDHLNFYC TASSLGNLIL
     SIKCEEVDGT EYLRIILRSK VKTLHERIPL AGFSKLPSIP QIAKAFCDDA SGLKFNPVLY
     PKASQMIVAY DEHEVNNTFK FGVIYQKFRQ TQEEELFGNN EESAAFRNFL NLLGDTITLQ
     DFKGFRGGLD VSHGQTGVES VYTVFRDREI MFHVSTKLPF TEGDTQQLQR KRHIGNDIVA
     IIFQEENTPF VPDMIASNFL HAYIVVQVEN PDADTTSYKV SVTAREDVPS FGPPLPSPPV
     FQKSPEFREF LLTKLINAEN ACCKSDKFAK LEDRTRAALL DNLHDELHGH TQTMLGLGPE
     EDKLENGGHG GFLESFKRAI RVRSHSMETM VGSQRKQHGG GIPGSLSGGI AHNSGEVTKT
     TFSPPVSAAT AKNQSRSPIK RRSGLFPRLH TGLESQVDSR ARCDSISGPQ KTPDVGHSSQ
     EMKSETSSNP SSPEICPNKD RPFVKLKENG RSNISRSSSS TSSFSSTAGE SETLEEYDSV
     GSQPSTASPF KQDVFIYSAS PGSDSPSVGA AATPVIMSRS PTDIKNRNSP RSNLKFRFDK
     LSHGSSSTSH