RPGRH_CAEEL
ID RPGRH_CAEEL Reviewed; 1386 AA.
AC Q5DX34;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2013, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=X-linked retinitis pigmentosa GTPase regulator homolog;
DE AltName: Full=Gut granule loss protein 4;
GN Name=glo-4; ORFNames=F07C3.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 99-109; 211-222; 364-370; 390-399; 404-431; 468-477;
RP 541-552; 585-598; 601-612; 859-868; 915-927 AND 1308-1317, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RA Bienvenut W.V.;
RL Submitted (FEB-2005) to UniProtKB.
RN [3] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=10767309; DOI=10.1093/hmg/9.6.869;
RA Culetto E., Sattelle D.B.;
RT "A role for Caenorhabditis elegans in understanding the function and
RT interactions of human disease genes.";
RL Hum. Mol. Genet. 9:869-877(2000).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15843430; DOI=10.1091/mbc.e05-01-0060;
RA Hermann G.J., Schroeder L.K., Hieb C.A., Kershner A.M., Rabbitts B.M.,
RA Fonarev P., Grant B.D., Priess J.R.;
RT "Genetic analysis of lysosomal trafficking in Caenorhabditis elegans.";
RL Mol. Biol. Cell 16:3273-3288(2005).
RN [5]
RP FUNCTION.
RX PubMed=21968191; DOI=10.1534/genetics.111.134791;
RA Tulgren E.D., Baker S.T., Rapp L., Gurney A.M., Grill B.;
RT "PPM-1, a PP2Calpha/beta phosphatase, regulates axon termination and
RT synapse formation in Caenorhabditis elegans.";
RL Genetics 189:1297-1307(2011).
CC -!- FUNCTION: Could be a guanine-nucleotide releasing factor for glo-1
CC (PubMed:15843430). May play a role in gut granule biogenesis
CC (PubMed:15843430). Regulates axon termination in PLM and ALM neurons
CC (PubMed:21968191). {ECO:0000269|PubMed:15843430,
CC ECO:0000269|PubMed:21968191}.
CC -!- DISRUPTION PHENOTYPE: Worms exhibit lack of intestinal gut granules.
CC {ECO:0000269|PubMed:15843430}.
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DR EMBL; FO081074; CCD68933.2; -; Genomic_DNA.
DR PIR; T28816; T28816.
DR PIR; T28817; T28817.
DR RefSeq; NP_505392.3; NM_072991.4.
DR AlphaFoldDB; Q5DX34; -.
DR SMR; Q5DX34; -.
DR BioGRID; 44344; 1.
DR STRING; 6239.F07C3.4; -.
DR EPD; Q5DX34; -.
DR PaxDb; Q5DX34; -.
DR PeptideAtlas; Q5DX34; -.
DR PRIDE; Q5DX34; -.
DR EnsemblMetazoa; F07C3.4.1; F07C3.4.1; WBGene00017195.
DR GeneID; 179306; -.
DR KEGG; cel:CELE_F07C3.4; -.
DR UCSC; F07C3.4; c. elegans.
DR CTD; 179306; -.
DR WormBase; F07C3.4; CE47730; WBGene00017195; glo-4.
DR eggNOG; KOG1426; Eukaryota.
DR HOGENOM; CLU_260451_0_0_1; -.
DR InParanoid; Q5DX34; -.
DR OMA; MANHEDV; -.
DR OrthoDB; 1062377at2759; -.
DR PRO; PR:Q5DX34; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00017195; Expressed in material anatomical entity and 5 other tissues.
DR GO; GO:0030424; C:axon; IDA:WormBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IDA:WormBase.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030517; P:negative regulation of axon extension; IGI:WormBase.
DR Gene3D; 2.130.10.30; -; 2.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR Pfam; PF00415; RCC1; 3.
DR PRINTS; PR00633; RCCNDNSATION.
DR SUPFAM; SSF50985; SSF50985; 1.
DR PROSITE; PS00626; RCC1_2; 3.
DR PROSITE; PS50012; RCC1_3; 4.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Guanine-nucleotide releasing factor;
KW Reference proteome; Repeat.
FT CHAIN 1..1386
FT /note="X-linked retinitis pigmentosa GTPase regulator
FT homolog"
FT /id="PRO_0000206640"
FT REPEAT 737..787
FT /note="RCC1 1"
FT REPEAT 788..838
FT /note="RCC1 2"
FT REPEAT 839..891
FT /note="RCC1 3"
FT REPEAT 893..943
FT /note="RCC1 4"
FT REPEAT 1034..1085
FT /note="RCC1 5"
FT REPEAT 1087..1139
FT /note="RCC1 6"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1386 AA; 152893 MW; 16C87EDC2151E89B CRC64;
MFFKRSTNSR KTSANSSSDT STSSESLLLP LLNNTKAGAR SQKGSVHRQS GKKARRKMME
NPYVCSLELD ELSADDSIID YSVFSDDSFL LILLLTSKGD VQAYLETSRD TKPRKNVVNI
KTACSLNVSP VTVCIGSQAA FAIFGLADGN LLVTPIRLLI DVTWGGSSWA TTTVIDLSLP
TVDPCLATPT CTKCFVSNFP PCTMAVVANK AGNILLVDLH LRKCVSELKA PQSLHQIDIL
LDENSIELLV TGFTGAQWII PIERSGKGFR EVLTTCVPSD LTVLEPATMQ FFAADSCGVV
ALDTTESIVE VYNTFHSLAH SSKRTFKVPP ETWMVHAGDN MLFTVSNDNE IRSALHFGFM
SSRLEYTLVR TSTNWRPLGI VAMPSRPHKL AGIFVVNERG LVRVEQSTAL NLTKIASEFF
FRLSPLQLNS KSVAQVANAC RIDTAEFQSA LIPNLLSTRK NRQLTNKELS QIYSIAKAIN
LSMSDLLKAF ENESIGEQLL PEVLNTIQTN PAKHDNLMQR VVEMFVKRSL SAEGNMDKIR
EYDAELSNFL ARHEHLHKGS VDCAKAGMWK CTQTLVRRDV HETKSIDTST EVLLYIIKNR
LQIWNEANST DRLQIMSLVC HLDWSKLADA DGARVCAILS AWQRDISLPS YHEMCLRIAI
TNSDRFPRPC QILSLVSSIH ILSEKKISNH ANLPNFLPLA GGNNCGATIT EDDRLMIWGN
FTNAQQRMEM PQMNAKSKRS DSVTNGAPTL PPPAPKPEQH LPRVLEYPGG RPRAIACGAE
HILVLSSSGQ LSAWGGNRFG QCGVGHSFRI ANLHQVDGDW PAIEKIACGQ FHSAFICSDG
SLWTFGWGVW GQLGHGGRNN SNQLVPTRVN GLICKVTQIA CGRAHTVVLT DTGRVLVCGS
GSYGQMGVDD DIKKVFAFTP LPLGPLRVRD IATHYYHSIC ITEDNRVFEW GRNPQELKMR
MFVMKKIRSA QLKNTEDPSS PSPSTNGSTP RVNLNLPAEI PREDLGLREV KHFLDGNIVS
VACGLSHSAL ITSEGTLYTW GKGLDYQLGH GNKNERMEPH QVFEPNGAKW VNVSLGNNHT
IASTDDGSVF AWGKNDFGQC GVLTKKNGNS ADVTKKFFFQ ARDGRRFMPN VDESQFVQKP
GLIPDVRVRN LNEDGNEGVD KEEIVDRLKA SDVNVVQAVS KHLYSPIEGK CNGSIIEDEP
RNGKIQKQNK YDGEDGPLCT TTALVHLIAG DVKRAIRMIE WLKTDSSTCE KSLMVLSSLV
WEVMANHEDV QSREALSAAF RHVPMSDSMR KGKQIAQLWP AVWNDERVQS SLSIDEKIAM
LDGFTSASKP VSCPTIPSSS LEVSSKIRVY AQCAHAEPAA VGSPPECSTC LDEWTEKVRH
TLGTQL
