ID   RPH1_SOLTU              Reviewed;         235 AA.
AC   M1C5M7;
DT   07-NOV-2018, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Protein RESISTANCE TO PHYTOPHTHORA 1, chloroplastic {ECO:0000303|PubMed:19170932};
DE            Short=StRPH1 {ECO:0000303|PubMed:19170932};
DE   Flags: Precursor;
GN   Name=RPH1 {ECO:0000303|PubMed:19170932};
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44;
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Kennebec;
RA   van der Hoeven R., Sun H., Karamycheva S.A., Tsai J., Van Aken S.,
RA   Utterback T., Chiemingo A., Bougri O., Buell C.R., Ronning C., Tanksley S.,
RA   Baker B.;
RT   "Generation of ESTs from potato roots.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=cv. Matilda;
RX   PubMed=19170932; DOI=10.1111/j.1365-313x.2008.03779.x;
RA   Belhaj K., Lin B., Mauch F.;
RT   "The chloroplast protein RPH1 plays a role in the immune response of
RT   Arabidopsis to Phytophthora brassicae.";
RL   Plant J. 58:287-298(2009).
CC   -!- FUNCTION: Plays a positive role in the immune response to the oomycetes
CC       P.infestans, including induced oxidative burst and enhanced expression
CC       of defense-related genes. {ECO:0000269|PubMed:19170932}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC       {ECO:0000250|UniProtKB:Q9ZU82}. Membrane {ECO:0000255}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Susceptiblility to the late blight oomycete
CC       pathogen P.infestans. {ECO:0000269|PubMed:19170932}.
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DR   EMBL; BM112240; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_006345816.1; XM_006345754.2.
DR   AlphaFoldDB; M1C5M7; -.
DR   STRING; 4113.PGSC0003DMT400060330; -.
DR   EnsemblPlants; PGSC0003DMT400060330; PGSC0003DMT400060330; PGSC0003DMG400023469.
DR   GeneID; 102592434; -.
DR   Gramene; PGSC0003DMT400060330; PGSC0003DMT400060330; PGSC0003DMG400023469.
DR   KEGG; sot:102592434; -.
DR   eggNOG; ENOG502QSK6; Eukaryota.
DR   HOGENOM; CLU_082560_1_0_1; -.
DR   InParanoid; M1C5M7; -.
DR   OMA; STEPDIW; -.
DR   OrthoDB; 1582768at2759; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   GO; GO:0009507; C:chloroplast; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0050665; P:hydrogen peroxide biosynthetic process; ISS:UniProtKB.
DR   GO; GO:1902290; P:positive regulation of defense response to oomycetes; IMP:UniProtKB.
DR   InterPro; IPR044966; RPH1.
DR   PANTHER; PTHR36359; PTHR36359; 1.
PE   2: Evidence at transcript level;
KW   Chloroplast; Membrane; Plant defense; Plastid; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..43
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000255"
FT   CHAIN           44..235
FT                   /note="Protein RESISTANCE TO PHYTOPHTHORA 1, chloroplastic"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000445600"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          53..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..82
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        20
FT                   /note="F -> S (in Ref. 2; BM112240)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        37
FT                   /note="I -> S (in Ref. 2; BM112240)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        61
FT                   /note="T -> I (in Ref. 2; BM112240)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        82
FT                   /note="E -> G (in Ref. 2; BM112240)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        231..233
FT                   /note="LQK -> ATE (in Ref. 2; BM112240)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   235 AA;  26243 MW;  F7678DDE6AFDDF83 CRC64;
     MNSATTMSAS VLNYQILKFF PPQKNGFLKS PLIRGKICRF CVSASSNELN KQVIEDPKEE
     TQEKSDGVIV NSTEEEEERS GENSTSTGPS TVLDNKELKK AVLKTASTFA PRASTATKNP
     AKPGTVLYTV FEVQAYASML IGGALSFNLI FPSTEPDIWR LMGMWSIWMF TIPSLRARDC
     SKDEKEALNY LFLLVPLLNV AIPFFLKSFA VVWSADTVAF LGMYAWKLGW LQKER