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RPH3L_HUMAN
ID   RPH3L_HUMAN             Reviewed;         315 AA.
AC   Q9UNE2; D3DTG7; Q9BSB3;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 158.
DE   RecName: Full=Rab effector Noc2;
DE   AltName: Full=No C2 domains protein;
DE   AltName: Full=Rabphilin-3A-like protein;
GN   Name=RPH3AL; Synonyms=NOC2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX   PubMed=10395805; DOI=10.1006/geno.1999.5864;
RA   Smith J.S., Tachibana I., Allen C., Chiappa S.A., Lee H.K., McIver B.,
RA   Jenkins R.B., Raffel C.;
RT   "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate
RT   17p13.3 medulloblastoma tumor suppressor locus.";
RL   Genomics 59:97-101(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION AS A RAB3B EFFECTOR, INTERACTION WITH RAB3B, SUBCELLULAR LOCATION,
RP   AND TISSUE SPECIFICITY.
RX   PubMed=15003533; DOI=10.1016/j.bbrc.2004.02.026;
RA   Manabe S., Nishimura N., Yamamoto Y., Kitamura H., Morimoto S., Imai M.,
RA   Nagahiro S., Seino S., Sasaki T.;
RT   "Identification and characterization of Noc2 as a potential Rab3B effector
RT   protein in epithelial cells.";
RL   Biochem. Biophys. Res. Commun. 316:218-225(2004).
CC   -!- FUNCTION: Rab GTPase effector involved in the late steps of regulated
CC       exocytosis, both in endocrine and exocrine cells (By similarity). Acts
CC       as a potential RAB3B effector protein in epithelial cells.
CC       {ECO:0000250, ECO:0000269|PubMed:15003533}.
CC   -!- SUBUNIT: Recruited to dense-core vesicles through specific interaction
CC       with RAB27A in endocrine cells. Interacts with RAB3A, RAB3B, RAB3C and
CC       RAB3D. Interacts with ZYX (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9UNE2; X5D778: ANKRD11; NbExp=3; IntAct=EBI-2855824, EBI-17183751;
CC       Q9UNE2; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-2855824, EBI-1166928;
CC       Q9UNE2; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-2855824, EBI-8643161;
CC       Q9UNE2; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-2855824, EBI-14103818;
CC       Q9UNE2; P61978-2: HNRNPK; NbExp=3; IntAct=EBI-2855824, EBI-7060731;
CC       Q9UNE2; O75525: KHDRBS3; NbExp=3; IntAct=EBI-2855824, EBI-722504;
CC       Q9UNE2; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-2855824, EBI-10172526;
CC       Q9UNE2; Q9UL41: PNMA3; NbExp=3; IntAct=EBI-2855824, EBI-11278955;
CC       Q9UNE2; O43741: PRKAB2; NbExp=3; IntAct=EBI-2855824, EBI-1053424;
CC       Q9UNE2; P61289: PSME3; NbExp=3; IntAct=EBI-2855824, EBI-355546;
CC       Q9UNE2; O00194: RAB27B; NbExp=3; IntAct=EBI-2855824, EBI-10179046;
CC       Q9UNE2; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-2855824, EBI-748350;
CC       Q9UNE2; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-2855824, EBI-748391;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15003533}.
CC       Cytoplasmic vesicle, secretory vesicle membrane
CC       {ECO:0000269|PubMed:15003533}. Note=Recruited to the vesicle membrane
CC       in a GTP- and RAB3B-dependent manner in epithelial cells.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9UNE2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9UNE2-2; Sequence=VSP_023244;
CC   -!- TISSUE SPECIFICITY: Moderate to high levels of expression in thyroid,
CC       ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver.
CC       Also detected in epithelial cells. {ECO:0000269|PubMed:10395805,
CC       ECO:0000269|PubMed:15003533}.
CC   -!- DOMAIN: The N-terminus of the RabBD domain is necessary and sufficient
CC       for interaction with RAB27A. {ECO:0000250}.
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DR   EMBL; AF129812; AAD45582.1; -; mRNA.
DR   EMBL; AK000469; BAA91186.1; -; mRNA.
DR   EMBL; CH471108; EAW90670.1; -; Genomic_DNA.
DR   EMBL; CH471108; EAW90671.1; -; Genomic_DNA.
DR   EMBL; BC005153; AAH05153.1; -; mRNA.
DR   EMBL; BC093776; AAH93776.1; -; mRNA.
DR   EMBL; BC113413; AAI13414.1; -; mRNA.
DR   CCDS; CCDS10994.1; -. [Q9UNE2-1]
DR   CCDS; CCDS54059.1; -. [Q9UNE2-2]
DR   RefSeq; NP_001177340.1; NM_001190411.1. [Q9UNE2-1]
DR   RefSeq; NP_001177341.1; NM_001190412.1. [Q9UNE2-2]
DR   RefSeq; NP_001177342.1; NM_001190413.1. [Q9UNE2-2]
DR   RefSeq; NP_008918.1; NM_006987.3. [Q9UNE2-1]
DR   RefSeq; XP_011533669.1; XM_011535367.2.
DR   RefSeq; XP_011533670.1; XM_011535368.2.
DR   AlphaFoldDB; Q9UNE2; -.
DR   SMR; Q9UNE2; -.
DR   BioGRID; 114880; 22.
DR   IntAct; Q9UNE2; 16.
DR   STRING; 9606.ENSP00000328977; -.
DR   iPTMnet; Q9UNE2; -.
DR   PhosphoSitePlus; Q9UNE2; -.
DR   BioMuta; RPH3AL; -.
DR   DMDM; 74735140; -.
DR   MassIVE; Q9UNE2; -.
DR   PaxDb; Q9UNE2; -.
DR   PeptideAtlas; Q9UNE2; -.
DR   PRIDE; Q9UNE2; -.
DR   ProteomicsDB; 85280; -. [Q9UNE2-1]
DR   ProteomicsDB; 85281; -. [Q9UNE2-2]
DR   Antibodypedia; 10243; 223 antibodies from 27 providers.
DR   DNASU; 9501; -.
DR   Ensembl; ENST00000323434.12; ENSP00000319210.8; ENSG00000181031.16. [Q9UNE2-2]
DR   Ensembl; ENST00000331302.12; ENSP00000328977.7; ENSG00000181031.16. [Q9UNE2-1]
DR   Ensembl; ENST00000536489.6; ENSP00000438224.2; ENSG00000181031.16. [Q9UNE2-2]
DR   Ensembl; ENST00000608278.2; ENSP00000483035.1; ENSG00000262334.6. [Q9UNE2-1]
DR   Ensembl; ENST00000608519.5; ENSP00000476394.1; ENSG00000262334.6. [Q9UNE2-2]
DR   Ensembl; ENST00000618002.4; ENSP00000479485.1; ENSG00000181031.16. [Q9UNE2-1]
DR   Ensembl; ENST00000632000.1; ENSP00000487689.1; ENSG00000262334.6. [Q9UNE2-2]
DR   Ensembl; ENST00000632545.1; ENSP00000487851.1; ENSG00000262334.6. [Q9UNE2-2]
DR   Ensembl; ENST00000632616.1; ENSP00000487649.1; ENSG00000262334.6. [Q9UNE2-1]
DR   GeneID; 9501; -.
DR   KEGG; hsa:9501; -.
DR   MANE-Select; ENST00000331302.12; ENSP00000328977.7; NM_006987.4; NP_008918.1.
DR   UCSC; uc002fre.3; human. [Q9UNE2-1]
DR   CTD; 9501; -.
DR   DisGeNET; 9501; -.
DR   GeneCards; RPH3AL; -.
DR   HGNC; HGNC:10296; RPH3AL.
DR   HPA; ENSG00000181031; Tissue enhanced (pancreas, pituitary gland).
DR   MIM; 604881; gene.
DR   neXtProt; NX_Q9UNE2; -.
DR   OpenTargets; ENSG00000181031; -.
DR   PharmGKB; PA34658; -.
DR   VEuPathDB; HostDB:ENSG00000181031; -.
DR   eggNOG; KOG1013; Eukaryota.
DR   GeneTree; ENSGT00440000034248; -.
DR   HOGENOM; CLU_076502_1_0_1; -.
DR   InParanoid; Q9UNE2; -.
DR   OMA; DCRKVRP; -.
DR   OrthoDB; 542090at2759; -.
DR   PhylomeDB; Q9UNE2; -.
DR   TreeFam; TF342971; -.
DR   PathwayCommons; Q9UNE2; -.
DR   SignaLink; Q9UNE2; -.
DR   BioGRID-ORCS; 9501; 11 hits in 1069 CRISPR screens.
DR   ChiTaRS; RPH3AL; human.
DR   GeneWiki; RPH3AL; -.
DR   GenomeRNAi; 9501; -.
DR   Pharos; Q9UNE2; Tbio.
DR   PRO; PR:Q9UNE2; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q9UNE2; protein.
DR   Bgee; ENSG00000181031; Expressed in body of pancreas and 94 other tissues.
DR   ExpressionAtlas; Q9UNE2; baseline and differential.
DR   Genevisible; Q9UNE2; HS.
DR   GO; GO:0005737; C:cytoplasm; TAS:ProtInc.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008092; F:cytoskeletal protein binding; TAS:ProtInc.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0045744; P:negative regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0017158; P:regulation of calcium ion-dependent exocytosis; IBA:GO_Central.
DR   GO; GO:0061669; P:spontaneous neurotransmitter secretion; IBA:GO_Central.
DR   CDD; cd15763; FYVE_RPH3L; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR041282; FYVE_2.
DR   InterPro; IPR041857; Noc2_FYVE.
DR   InterPro; IPR010911; Rab_BD.
DR   InterPro; IPR030538; Rab_effect_Noc2.
DR   InterPro; IPR043566; Rabphilin/DOC2/Noc2.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR45729; PTHR45729; 1.
DR   PANTHER; PTHR45729:SF4; PTHR45729:SF4; 1.
DR   Pfam; PF02318; FYVE_2; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS50916; RABBD; 1.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasm; Cytoplasmic vesicle; Exocytosis; Membrane;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..315
FT                   /note="Rab effector Noc2"
FT                   /id="PRO_0000278263"
FT   DOMAIN          41..158
FT                   /note="RabBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00234"
FT   ZN_FING         89..146
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT   REGION          170..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..193
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..243
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         95
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT   BINDING         98
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT   BINDING         112
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT   BINDING         115
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT   BINDING         120
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT   BINDING         123
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT   BINDING         138
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT   BINDING         141
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT   VAR_SEQ         118..146
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_023244"
FT   CONFLICT        85
FT                   /note="R -> Q (in Ref. 4; AAH05153)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   315 AA;  34464 MW;  FDDB315E0BBC7C23 CRC64;
     MADTIFGSGN DQWVCPNDRQ LALRAKLQTG WSVHTYQTEK QRRKQHLSPA EVEAILQVIQ
     RAERLDVLEQ QRIGRLVERL ETMRRNVMGN GLSQCLLCGE VLGFLGSSSV FCKDCRKKVC
     TKCGIEASPG QKRPLWLCKI CSEQREVWKR SGAWFYKGLP KYILPLKTPG RADDPHFRPL
     PTEPAEREPR SSETSRIYTW ARGRVVSSDS DSDSDLSSSS LEDRLPSTGV RDRKGDKPWK
     ESGGSVEAPR MGFTHPPGHL SGCQSSLASG ETGTGSADPP GGPRPGLTRR APVKDTPGRA
     PAADAAPAGP SSCLG
 
 
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