RPI1_CAEEL
ID RPI1_CAEEL Reviewed; 450 AA.
AC Q69Z08; Q9XUK0;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein rpi-1 {ECO:0000305};
GN Name=rpi-1 {ECO:0000303|PubMed:27930654};
GN ORFNames=W07G1.5 {ECO:0000312|WormBase:W07G1.5b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=27930654; DOI=10.1371/journal.pgen.1006469;
RA Jensen V.L., Carter S., Sanders A.A., Li C., Kennedy J., Timbers T.A.,
RA Cai J., Scheidel N., Kennedy B.N., Morin R.D., Leroux M.R., Blacque O.E.;
RT "Whole-organism developmental expression profiling identifies rab-28 as a
RT novel ciliary GTPase associated with the BBSome and intraflagellar
RT transport.";
RL PLoS Genet. 12:E1006469-E1006469(2016).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000305};
CC Single-pass membrane protein {ECO:0000255}. Cell projection, cilium
CC {ECO:0000269|PubMed:27930654}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:27930654}. Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:27930654}. Note=Localizes to the base of the
CC cilium. Localizes to ciliary and cytoplasmic microtubules.
CC {ECO:0000269|PubMed:27930654}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b {ECO:0000312|WormBase:W07G1.5b};
CC IsoId=Q69Z08-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:W07G1.5a};
CC IsoId=Q69Z08-2; Sequence=VSP_058799;
CC -!- TISSUE SPECIFICITY: Expressed in amphid and phasmid ciliated neurons.
CC {ECO:0000269|PubMed:27930654}.
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DR EMBL; BX284602; CAB04937.2; -; Genomic_DNA.
DR EMBL; BX284602; CAH10809.1; -; Genomic_DNA.
DR PIR; T26269; T26269.
DR RefSeq; NP_001022398.1; NM_001027227.3. [Q69Z08-2]
DR RefSeq; NP_001022399.1; NM_001027228.3. [Q69Z08-1]
DR AlphaFoldDB; Q69Z08; -.
DR SMR; Q69Z08; -.
DR DIP; DIP-24816N; -.
DR IntAct; Q69Z08; 2.
DR STRING; 6239.W07G1.5b; -.
DR PaxDb; Q69Z08; -.
DR PeptideAtlas; Q69Z08; -.
DR EnsemblMetazoa; W07G1.5a.1; W07G1.5a.1; WBGene00012332. [Q69Z08-2]
DR EnsemblMetazoa; W07G1.5b.1; W07G1.5b.1; WBGene00012332. [Q69Z08-1]
DR GeneID; 189281; -.
DR KEGG; cel:CELE_W07G1.5; -.
DR UCSC; W07G1.5a; c. elegans.
DR CTD; 189281; -.
DR WormBase; W07G1.5a; CE35636; WBGene00012332; rpi-1. [Q69Z08-2]
DR WormBase; W07G1.5b; CE37053; WBGene00012332; rpi-1. [Q69Z08-1]
DR eggNOG; KOG3757; Eukaryota.
DR GeneTree; ENSGT00940000164359; -.
DR HOGENOM; CLU_047753_0_0_1; -.
DR InParanoid; Q69Z08; -.
DR OMA; FIPMRYG; -.
DR OrthoDB; 1351279at2759; -.
DR PRO; PR:Q69Z08; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00012332; Expressed in pharyngeal muscle cell (C elegans) and 2 other tissues.
DR GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR GO; GO:0097546; C:ciliary base; IDA:UniProtKB.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035869; C:ciliary transition zone; IDA:UniProtKB.
DR GO; GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 3.10.20.230; -; 1.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR Pfam; PF03607; DCX; 1.
DR SMART; SM00537; DCX; 1.
DR SUPFAM; SSF89837; SSF89837; 1.
DR PROSITE; PS50309; DC; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Cell projection; Cilium; Cytoplasm;
KW Cytoskeleton; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..450
FT /note="Protein rpi-1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000439162"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 35..115
FT /note="Doublecortin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..418
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 340..351
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_058799"
SQ SEQUENCE 450 AA; 48674 MW; 2EA3D9D5519F3A15 CRC64;
MPTPSTKKKV KKVAEDPLSS SGVSSLSGIS SYNIRKISIY KNGDRYHRGV KFVINPRVIK
DMEPLLNQVN DRIELSHGAK KLYTTDGKIV NSIKELEDGK IYVAASAQFI PMRYGEFAEK
VWKPPSRKHS PIMSSDRIKT ARTRSQDPSK RRQPQNSGSS APTGSGVQRS RSVRTLAEDR
KSRRDANPAR PNVNGASNAP KKFDGARPKA PPARQTIPKP KKILTTSTTN KKPPTPKRKV
SKKVLGAAAA AGVTVVGAAA IGAVAAAKRS TPKPIPTAVS DVSTASSIPI PNVTGAAEIL
EFPEEEKKID MATIHRTPTP PVVASRPATA KAPGTPANRS ATALEAKSVS QQPTPESSEE
EEDEGNGDED DDEEVEDDEE DAGSDEAEEE PSDEEEEDEE TEEEEEEEEE EEEDDDESRV
ETPASRKSSS AVSFSGSTEE DHKKGDEAKK
