ID   RPIA_CAEEL              Reviewed;         251 AA.
AC   P41994;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Probable-ribose 5-phosphate isomerase;
DE            EC=5.3.1.6;
DE   AltName: Full=Phosphoriboisomerase;
GN   Name=rpia-1; ORFNames=B0280.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:14657, ChEBI:CHEBI:58121, ChEBI:CHEBI:58273;
CC         EC=5.3.1.6;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribose
CC       5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step
CC       1/1.
CC   -!- SIMILARITY: Belongs to the ribose 5-phosphate isomerase family.
CC       {ECO:0000305}.
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DR   EMBL; FO080148; CCD61600.1; -; Genomic_DNA.
DR   PIR; T15307; T15307.
DR   RefSeq; NP_498556.1; NM_066155.5.
DR   AlphaFoldDB; P41994; -.
DR   SMR; P41994; -.
DR   BioGRID; 41207; 14.
DR   IntAct; P41994; 2.
DR   STRING; 6239.B0280.3.2; -.
DR   EPD; P41994; -.
DR   PaxDb; P41994; -.
DR   PeptideAtlas; P41994; -.
DR   EnsemblMetazoa; B0280.3.1; B0280.3.1; WBGene00015101.
DR   EnsemblMetazoa; B0280.3.2; B0280.3.2; WBGene00015101.
DR   GeneID; 175995; -.
DR   KEGG; cel:CELE_B0280.3; -.
DR   UCSC; B0280.3.1; c. elegans.
DR   CTD; 175995; -.
DR   WormBase; B0280.3; CE00733; WBGene00015101; rpia-1.
DR   eggNOG; KOG3075; Eukaryota.
DR   GeneTree; ENSGT00390000004352; -.
DR   HOGENOM; CLU_056590_0_2_1; -.
DR   InParanoid; P41994; -.
DR   OMA; YDWDEVN; -.
DR   OrthoDB; 1074761at2759; -.
DR   PhylomeDB; P41994; -.
DR   Reactome; R-CEL-71336; Pentose phosphate pathway.
DR   UniPathway; UPA00115; UER00412.
DR   PRO; PR:P41994; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00015101; Expressed in larva and 4 other tissues.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0004751; F:ribose-5-phosphate isomerase activity; IBA:GO_Central.
DR   GO; GO:0006014; P:D-ribose metabolic process; IBA:GO_Central.
DR   GO; GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IBA:GO_Central.
DR   CDD; cd01398; RPI_A; 1.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR004788; Ribose5P_isomerase_type_A.
DR   PANTHER; PTHR11934; PTHR11934; 1.
DR   Pfam; PF06026; Rib_5-P_isom_A; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR00021; rpiA; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..251
FT                   /note="Probable-ribose 5-phosphate isomerase"
FT                   /id="PRO_0000158523"
SQ   SEQUENCE   251 AA;  27221 MW;  F6849D1224626B68 CRC64;
     MVTSTGPEAE LAPIEQAKKR AAFACGEKYV QSGCRLGVGS GSTVKYLVEY LKQGFQNGSL
     KDIICVPTSF LTKQWLIESG LPVSDLDSHP ELDVCIDGAD EVDGQFTCIK GGGGCLAQEK
     IVQTAAKNFY VIADYLKDSK HLGDRYPNVP IEVLPLAAQP LLRSIPRAEG GSCQLRQAVK
     KCGPIVTDNG NFIIDWQFEK NVSGRDWFAI QQRLANTPGI VETGLFIGCV DAVFFAYSDG
     SVKEIVNSKK H