ID   RPIA_CRYNB              Reviewed;         302 AA.
AC   P0CR19; Q55UH9; Q5KHW6;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Ribose-5-phosphate isomerase;
DE            EC=5.3.1.6;
DE   AltName: Full=D-ribose-5-phosphate ketol-isomerase;
DE   AltName: Full=Phosphoriboisomerase;
GN   Name=RKI1; OrderedLocusNames=CNBD1280;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:14657, ChEBI:CHEBI:58121, ChEBI:CHEBI:58273;
CC         EC=5.3.1.6;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribose
CC       5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step
CC       1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ribose 5-phosphate isomerase family.
CC       {ECO:0000305}.
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DR   EMBL; AAEY01000019; EAL21433.1; -; Genomic_DNA.
DR   RefSeq; XP_776080.1; XM_770987.1.
DR   AlphaFoldDB; P0CR19; -.
DR   SMR; P0CR19; -.
DR   EnsemblFungi; AAW43129; AAW43129; CND05060.
DR   EnsemblFungi; EAL21433; EAL21433; CNBD1280.
DR   GeneID; 4935517; -.
DR   KEGG; cnb:CNBD1280; -.
DR   VEuPathDB; FungiDB:CNBD1280; -.
DR   HOGENOM; CLU_056590_0_1_1; -.
DR   UniPathway; UPA00115; UER00412.
DR   Proteomes; UP000001435; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004751; F:ribose-5-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IEA:InterPro.
DR   CDD; cd01398; RPI_A; 1.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR004788; Ribose5P_isomerase_type_A.
DR   PANTHER; PTHR11934; PTHR11934; 1.
DR   Pfam; PF06026; Rib_5-P_isom_A; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR00021; rpiA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Isomerase.
FT   CHAIN           1..302
FT                   /note="Ribose-5-phosphate isomerase"
FT                   /id="PRO_0000410270"
SQ   SEQUENCE   302 AA;  32100 MW;  10FF72C948050C45 CRC64;
     MPSPAVDLLK QKTASLPNAP ISVVAANTFV PPTQPVTAGN QLPTSVPLPV LPAVEAAKRL
     AAYAAVDRHI AHEHKVIGIG SGSTVPYVVD RILAQGFEAN KDRVFLPTGF QSKELIVKAG
     LTLGDVDQYA RIDVTIDGAD EVDNELNSIK GGGACQLREK VLAEAADTWI IVADYRKNSE
     VLGTSWTKGI PIEVVPFAYA KVLTNLAHMG SPHVLPNGQP GLSLRMGKMK AGPVVSDNGN
     FIIDAPFAEE LMRQPEELLH KIKMLTGVVE VGLFCGMAKA AYFGNEDGSV TIRSDDGTIS
     QL