AB2G_ARATH
ID AB2G_ARATH Reviewed; 755 AA.
AC Q9ZUT0; Q8GYL8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=ABC transporter G family member 2;
DE Short=ABC transporter ABCG.2;
DE Short=AtABCG2;
DE AltName: Full=White-brown complex homolog protein 2;
DE Short=AtWBC2;
GN Name=ABCG2; Synonyms=WBC2; OrderedLocusNames=At2g37360; ORFNames=F3G5.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 478-755.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC005896; AAC98055.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09388.1; -; Genomic_DNA.
DR EMBL; AK117523; BAC42186.1; -; mRNA.
DR PIR; G84791; G84791.
DR RefSeq; NP_181272.1; NM_129291.4.
DR AlphaFoldDB; Q9ZUT0; -.
DR SMR; Q9ZUT0; -.
DR BioGRID; 3656; 25.
DR IntAct; Q9ZUT0; 22.
DR STRING; 3702.AT2G37360.1; -.
DR PaxDb; Q9ZUT0; -.
DR PRIDE; Q9ZUT0; -.
DR ProteomicsDB; 244575; -.
DR EnsemblPlants; AT2G37360.1; AT2G37360.1; AT2G37360.
DR GeneID; 818312; -.
DR Gramene; AT2G37360.1; AT2G37360.1; AT2G37360.
DR KEGG; ath:AT2G37360; -.
DR Araport; AT2G37360; -.
DR TAIR; locus:2049806; AT2G37360.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_8_1; -.
DR InParanoid; Q9ZUT0; -.
DR OMA; YVALLCM; -.
DR OrthoDB; 1022017at2759; -.
DR PhylomeDB; Q9ZUT0; -.
DR PRO; PR:Q9ZUT0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZUT0; differential.
DR Genevisible; Q9ZUT0; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0010345; P:suberin biosynthetic process; IGI:TAIR.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005284; Pigment_permease/Abcg.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00955; 3a01204; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..755
FT /note="ABC transporter G family member 2"
FT /id="PRO_0000240674"
FT TRANSMEM 468..488
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 503..523
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 579..599
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 609..629
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 728..748
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 98..358
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 449..659
FT /note="ABC transmembrane type-2"
FT BINDING 151..158
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 755 AA; 83456 MW; 3D6AD3DD645C176B CRC64;
MSGLLGKSSP AKRVDGNNDL PMYYVNPMSV EPQGRPSDTT RVSVTFAEHL MNVEDARNDE
SASSRALGIA SPINSAASSF NSWASAPASS ISSSPFVLSF TDLTYSVKIQ KKFNPLACCR
RSGNDSSVNT KILLNGISGE AREGEMMAVL GASGSGKSTL IDALANRIAK DSLRGSITLN
GEVLESSMQK VISAYVMQDD LLFPMLTVEE TLMFSAEFRL PRSLSKKKKK ARVQALIDQL
GLRSAAKTVI GDEGHRGVSG GERRRVSIGN DIIHDPIILF LDEPTSGLDS TSAYMVIKVL
QRIAQSGSIV IMSIHQPSYR IMGLLDQLIF LSKGNTVYSG SPTHLPQFFS EFKHPIPENE
NKTEFALDLI RELEYSTEGT KPLVEFHKQW RAKQAPSYNN NNKRNTNVSS LKEAITASIS
RGKLVSGATN NNSSNLTPSF QTFANPFWIE MIVIGKRAIL NSRRQPELLG MRLGAVMVTG
IILATMFTNL DNSPKGAQER LGFFAFAMST TFYTCAEAIP VFLQERYIFM RETAYNAYRR
SSYVLSQSII SIPALIVLSA SFAATTFWAV GLDGGANGFF FFYFTILASF WAGSSFVTFL
SGVIPNVMLG FTVVVAILAY FLLFSGFFIS RDRIPVYWLW FHYISLVKYP YEGVLQNEFQ
NPTRCFARGV QLFDNSPLGE FPNDVKVNLL KSMSGVLGTN VTAETCVTTG IDILKQQGIT
DISKWNCLWI TVAWGFFFRV LFYFTLLIGS KNKRK