RPIA_NEIG2
ID RPIA_NEIG2 Reviewed; 223 AA.
AC B4RL16;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Ribose-5-phosphate isomerase A {ECO:0000255|HAMAP-Rule:MF_00170};
DE EC=5.3.1.6 {ECO:0000255|HAMAP-Rule:MF_00170};
DE AltName: Full=Phosphoriboisomerase A {ECO:0000255|HAMAP-Rule:MF_00170};
DE Short=PRI {ECO:0000255|HAMAP-Rule:MF_00170};
GN Name=rpiA {ECO:0000255|HAMAP-Rule:MF_00170}; OrderedLocusNames=NGK_0826;
OS Neisseria gonorrhoeae (strain NCCP11945).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=521006;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCCP11945;
RX PubMed=18586945; DOI=10.1128/jb.00566-08;
RA Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.;
RT "Complete genome sequence of Neisseria gonorrhoeae NCCP11945.";
RL J. Bacteriol. 190:6035-6036(2008).
CC -!- FUNCTION: Catalyzes the reversible conversion of ribose-5-phosphate to
CC ribulose 5-phosphate. {ECO:0000255|HAMAP-Rule:MF_00170}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate;
CC Xref=Rhea:RHEA:14657, ChEBI:CHEBI:58121, ChEBI:CHEBI:58273;
CC EC=5.3.1.6; Evidence={ECO:0000255|HAMAP-Rule:MF_00170};
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribose
CC 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step
CC 1/1. {ECO:0000255|HAMAP-Rule:MF_00170}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00170}.
CC -!- SIMILARITY: Belongs to the ribose 5-phosphate isomerase family.
CC {ECO:0000255|HAMAP-Rule:MF_00170}.
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DR EMBL; CP001050; ACF29507.1; -; Genomic_DNA.
DR RefSeq; WP_003688327.1; NC_011035.1.
DR PDB; 5UF2; X-ray; 1.40 A; A=1-223.
DR PDBsum; 5UF2; -.
DR AlphaFoldDB; B4RL16; -.
DR SMR; B4RL16; -.
DR EnsemblBacteria; ACF29507; ACF29507; NGK_0826.
DR GeneID; 66753291; -.
DR KEGG; ngk:NGK_0826; -.
DR HOGENOM; CLU_056590_1_1_4; -.
DR OMA; YDWDEVN; -.
DR OrthoDB; 1681738at2; -.
DR UniPathway; UPA00115; UER00412.
DR Proteomes; UP000002564; Chromosome.
DR GO; GO:0004751; F:ribose-5-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IEA:UniProtKB-UniRule.
DR CDD; cd01398; RPI_A; 1.
DR HAMAP; MF_00170; Rib_5P_isom_A; 1.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR020672; Ribose5P_isomerase_typA_subgr.
DR InterPro; IPR004788; Ribose5P_isomerase_type_A.
DR PANTHER; PTHR11934; PTHR11934; 1.
DR Pfam; PF06026; Rib_5-P_isom_A; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR00021; rpiA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Isomerase.
FT CHAIN 1..223
FT /note="Ribose-5-phosphate isomerase A"
FT /id="PRO_1000097678"
FT ACT_SITE 104
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00170"
FT BINDING 29..32
FT /ligand="substrate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00170"
FT BINDING 82..85
FT /ligand="substrate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00170"
FT BINDING 95..98
FT /ligand="substrate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00170"
FT BINDING 122
FT /ligand="substrate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00170"
FT HELIX 4..15
FT /evidence="ECO:0007829|PDB:5UF2"
FT HELIX 16..18
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 23..27
FT /evidence="ECO:0007829|PDB:5UF2"
FT HELIX 31..43
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 48..54
FT /evidence="ECO:0007829|PDB:5UF2"
FT HELIX 55..63
FT /evidence="ECO:0007829|PDB:5UF2"
FT HELIX 71..73
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 77..82
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 85..87
FT /evidence="ECO:0007829|PDB:5UF2"
FT HELIX 101..109
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 114..119
FT /evidence="ECO:0007829|PDB:5UF2"
FT HELIX 120..122
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 125..127
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 132..136
FT /evidence="ECO:0007829|PDB:5UF2"
FT HELIX 138..140
FT /evidence="ECO:0007829|PDB:5UF2"
FT HELIX 141..151
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 154..157
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 168..174
FT /evidence="ECO:0007829|PDB:5UF2"
FT HELIX 180..188
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 193..200
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 205..211
FT /evidence="ECO:0007829|PDB:5UF2"
FT STRAND 214..218
FT /evidence="ECO:0007829|PDB:5UF2"
SQ SEQUENCE 223 AA; 23890 MW; 4F781726C0F0B73F CRC64;
MTTQDELKRI AAEKAVEFVP ENEYIGIGTG STINFFIEAL GKSGKKIKGA VSTSKKSGEL
LARYDIPVVS LNEVSGLAVY IDGADEVNHA LQMIKGGGGA HLNEKIVASA SEKFVCIADE
SKYVSRLGKF PLPVEAVESA RSLVSRKLLA MGGQPELRIG YTTFYGNQIV DVHGLNIDQP
LTMEDEINKI TGVLENGIFA RDAADVLILG TEEGAKVIYP CQG
