ID   RPIA_PICST              Reviewed;         237 AA.
AC   A3LP13;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Ribose-5-phosphate isomerase;
DE            EC=5.3.1.6;
DE   AltName: Full=D-ribose-5-phosphate ketol-isomerase;
DE   AltName: Full=Phosphoriboisomerase;
GN   Name=RKI1; ORFNames=PICST_76151;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:14657, ChEBI:CHEBI:58121, ChEBI:CHEBI:58273;
CC         EC=5.3.1.6;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribose
CC       5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step
CC       1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ribose 5-phosphate isomerase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000496; ABN64970.1; -; Genomic_DNA.
DR   RefSeq; XP_001382999.1; XM_001382962.1.
DR   AlphaFoldDB; A3LP13; -.
DR   SMR; A3LP13; -.
DR   STRING; 4924.XP_001382999.1; -.
DR   EnsemblFungi; ABN64970; ABN64970; PICST_76151.
DR   GeneID; 4837111; -.
DR   KEGG; pic:PICST_76151; -.
DR   eggNOG; KOG3075; Eukaryota.
DR   HOGENOM; CLU_056590_0_0_1; -.
DR   InParanoid; A3LP13; -.
DR   OMA; YDWDEVN; -.
DR   OrthoDB; 1074761at2759; -.
DR   UniPathway; UPA00115; UER00412.
DR   Proteomes; UP000002258; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004751; F:ribose-5-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IEA:InterPro.
DR   CDD; cd01398; RPI_A; 1.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR004788; Ribose5P_isomerase_type_A.
DR   PANTHER; PTHR11934; PTHR11934; 1.
DR   Pfam; PF06026; Rib_5-P_isom_A; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR00021; rpiA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Isomerase; Reference proteome.
FT   CHAIN           1..237
FT                   /note="Ribose-5-phosphate isomerase"
FT                   /id="PRO_0000339891"
SQ   SEQUENCE   237 AA;  25220 MW;  DA20BF124A65F437 CRC64;
     MSSLSLVEQA KKSAAYQAVD ENFPVSAKVV GIGSGSTVVY VAERIGQLAN KDSFVCIPTG
     FQSKQLIIDN GLKLGAIEQF PEIDIAFDGA DEVDPALNLI KGGGACLFQE KLVAASAKTF
     VVVADYRKKS DNLGIQWKQG VPIEIVPNSY AKVIQDLKKL GAITVNLRQG GSAKAGPIIT
     DNNNFLLDAD FGAIKDPKAL HDQIKALVGV VETGLFTSMA AKSYFGEQDG QVNIWSI