ID   RPIA_PIG                Reviewed;         306 AA.
AC   A2TLM1;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Ribose-5-phosphate isomerase;
DE            EC=5.3.1.6;
DE   AltName: Full=Phosphoriboisomerase;
GN   Name=RPIA {ECO:0000250|UniProtKB:P49247};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1] {ECO:0000312|EMBL:ABM98101.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Oocyte {ECO:0000312|EMBL:ABM98101.1};
RA   Kim Y.S., Yoon S.J., Lee H.T., Lee K.A.;
RT   "Differential expression of RPIA in oocyte and follicular cells.";
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:14657, ChEBI:CHEBI:58121, ChEBI:CHEBI:58273;
CC         EC=5.3.1.6; Evidence={ECO:0000250|UniProtKB:P49247};
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribose
CC       5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step
CC       1/1. {ECO:0000250|UniProtKB:P49247}.
CC   -!- SIMILARITY: Belongs to the ribose 5-phosphate isomerase family.
CC       {ECO:0000255}.
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DR   EMBL; EF213106; ABM98101.1; -; mRNA.
DR   RefSeq; NP_001090964.1; NM_001097495.1.
DR   AlphaFoldDB; A2TLM1; -.
DR   SMR; A2TLM1; -.
DR   STRING; 9823.ENSSSCP00000008762; -.
DR   PaxDb; A2TLM1; -.
DR   PeptideAtlas; A2TLM1; -.
DR   PRIDE; A2TLM1; -.
DR   GeneID; 100038014; -.
DR   KEGG; ssc:100038014; -.
DR   CTD; 22934; -.
DR   eggNOG; KOG3075; Eukaryota.
DR   InParanoid; A2TLM1; -.
DR   OrthoDB; 1074761at2759; -.
DR   UniPathway; UPA00115; UER00412.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0004751; F:ribose-5-phosphate isomerase activity; IBA:GO_Central.
DR   GO; GO:0006014; P:D-ribose metabolic process; IBA:GO_Central.
DR   GO; GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IBA:GO_Central.
DR   CDD; cd01398; RPI_A; 1.
DR   HAMAP; MF_00170; Rib_5P_isom_A; 1.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR020672; Ribose5P_isomerase_typA_subgr.
DR   InterPro; IPR004788; Ribose5P_isomerase_type_A.
DR   PANTHER; PTHR11934; PTHR11934; 1.
DR   Pfam; PF06026; Rib_5-P_isom_A; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR00021; rpiA; 1.
PE   2: Evidence at transcript level;
KW   Isomerase; Phosphoprotein; Reference proteome.
FT   CHAIN           1..306
FT                   /note="Ribose-5-phosphate isomerase"
FT                   /id="PRO_0000296297"
FT   REGION          45..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         102
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P49247"
SQ   SEQUENCE   306 AA;  32695 MW;  C5992239A038F232 CRC64;
     MQRLGPFSTL YGRVLAPLPG RAGGAASGGG GNSWGVLGSH VQPPGRAQFG VGSTSTSSGD
     ANSVCPAPST MSKAEEAKKL AGRAAVENHV RNNQVLGIGS GSTIVHAVQR IAERVKQENL
     NLICIPTSFQ ARQLILQHGL TLSDLDRHPE IDLAIDGADE VDADLNLIKG GGGCLTQEKI
     VAGNASRFIV IADFRKDSKN LGDQWHKGIP IEVIPMAYVP VSRTVTQKFG GVIELRMAVN
     KAGPVVTDNG NFILDWKFDR VHKWSEVNTA ITMIPGVVDT GLFINMAERV YFGMQDGSVN
     MREKPF