RPIR_ECOLI
ID RPIR_ECOLI Reviewed; 296 AA.
AC P0ACS7; P39266; P76791; Q2M6L4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=HTH-type transcriptional regulator RpiR;
DE AltName: Full=Als operon repressor;
GN Name=rpiR; Synonyms=alsR, yjcY; OrderedLocusNames=b4089, JW4050;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=8576032; DOI=10.1128/jb.178.4.1003-1011.1996;
RA Soerensen K.I., Hove-Jensen B.;
RT "Ribose catabolism of Escherichia coli: characterization of the rpiB gene
RT encoding ribose phosphate isomerase B and of the rpiR gene, which is
RT involved in regulation of rpiB expression.";
RL J. Bacteriol. 178:1003-1011(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP FUNCTION IN ALS REPRESSION.
RX PubMed=9401019; DOI=10.1128/jb.179.24.7631-7637.1997;
RA Kim C., Song S., Park C.;
RT "The D-allose operon of Escherichia coli K-12.";
RL J. Bacteriol. 179:7631-7637(1997).
CC -!- FUNCTION: Regulatory protein involved in rpiB gene repression. Also
CC involved in als operon repression. {ECO:0000269|PubMed:9401019}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA96988.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; X82203; CAA57687.1; -; Genomic_DNA.
DR EMBL; U14003; AAA96988.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC77050.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE78092.1; -; Genomic_DNA.
DR PIR; S56317; S56317.
DR RefSeq; NP_418513.4; NC_000913.3.
DR RefSeq; WP_000083216.1; NZ_STEB01000014.1.
DR AlphaFoldDB; P0ACS7; -.
DR SMR; P0ACS7; -.
DR BioGRID; 4262682; 11.
DR IntAct; P0ACS7; 5.
DR STRING; 511145.b4089; -.
DR jPOST; P0ACS7; -.
DR PaxDb; P0ACS7; -.
DR PRIDE; P0ACS7; -.
DR DNASU; 948603; -.
DR EnsemblBacteria; AAC77050; AAC77050; b4089.
DR EnsemblBacteria; BAE78092; BAE78092; BAE78092.
DR GeneID; 948603; -.
DR KEGG; ecj:JW4050; -.
DR KEGG; eco:b4089; -.
DR PATRIC; fig|511145.12.peg.4216; -.
DR EchoBASE; EB2353; -.
DR eggNOG; COG1737; Bacteria.
DR HOGENOM; CLU_055769_0_5_6; -.
DR InParanoid; P0ACS7; -.
DR OMA; DSHMMLM; -.
DR PhylomeDB; P0ACS7; -.
DR BioCyc; EcoCyc:G7821-MON; -.
DR PRO; PR:P0ACS7; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd05013; SIS_RpiR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR000281; HTH_RpiR.
DR InterPro; IPR035472; RpiR-like_SIS.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF01418; HTH_6; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF53697; SSF53697; 1.
DR PROSITE; PS51071; HTH_RPIR; 1.
DR PROSITE; PS51464; SIS; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..296
FT /note="HTH-type transcriptional regulator RpiR"
FT /id="PRO_0000068620"
FT DOMAIN 14..90
FT /note="HTH rpiR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
FT DOMAIN 134..274
FT /note="SIS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT DNA_BIND 50..69
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
SQ SEQUENCE 296 AA; 32362 MW; 7946848F0798E200 CRC64;
MSQSEFDSAL PNGIGLAPYL RMKQEGMTEN ESRIVEWLLK PGNLSCAPAI KDVAEALAVS
EAMIVKVSKL LGFSGFRNLR SALEDYFSQS EQVLPSELAF DEAPQDVVNK VFNITLRTIM
EGQSIVNVDE IHRAARFFYQ ARQRDLYGAG GSNAICADVQ HKFLRIGVRC QAYPDAHIMM
MSASLLQEGD VVLVVTHSGR TSDVKAAVEL AKKNGAKIIC ITHSYHSPIA KLADYIICSP
APETPLLGRN ASARILQLTL LDAFFVSVAQ LNIEQANINM QKTGAIVDFF SPGALK
