RPN1_NEUCR
ID RPN1_NEUCR Reviewed; 902 AA.
AC Q7S8R8;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=26S proteasome regulatory subunit rpn-1;
GN Name=rpn-1; ORFNames=NCU07721;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26 proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S2 family. {ECO:0000305}.
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DR EMBL; CM002239; EAA32735.2; -; Genomic_DNA.
DR RefSeq; XP_961971.2; XM_956878.3.
DR AlphaFoldDB; Q7S8R8; -.
DR SMR; Q7S8R8; -.
DR STRING; 5141.EFNCRP00000008058; -.
DR PRIDE; Q7S8R8; -.
DR EnsemblFungi; EAA32735; EAA32735; NCU07721.
DR GeneID; 3878119; -.
DR KEGG; ncr:NCU07721; -.
DR VEuPathDB; FungiDB:NCU07721; -.
DR HOGENOM; CLU_008705_1_0_1; -.
DR InParanoid; Q7S8R8; -.
DR OMA; KTVYKHM; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:1905754; C:ascospore-type prospore nucleus; IEA:EnsemblFungi.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0031595; C:nuclear proteasome complex; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IBA:GO_Central.
DR GO; GO:0034515; C:proteasome storage granule; IBA:GO_Central.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:EnsemblFungi.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR016643; 26S_Psome_Rpn1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR041433; RPN1_C.
DR InterPro; IPR040892; RPN1_N.
DR PANTHER; PTHR10943:SF1; PTHR10943:SF1; 1.
DR Pfam; PF01851; PC_rep; 2.
DR Pfam; PF18051; RPN1_C; 1.
DR Pfam; PF17781; RPN1_RPN2_N; 1.
DR PIRSF; PIRSF015965; 26S_Psome_Rpn1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Proteasome; Reference proteome; Repeat.
FT CHAIN 1..902
FT /note="26S proteasome regulatory subunit rpn-1"
FT /id="PRO_0000173813"
FT REPEAT 415..448
FT /note="PC 1"
FT REPEAT 449..487
FT /note="PC 2"
FT REPEAT 488..522
FT /note="PC 3"
FT REPEAT 525..559
FT /note="PC 4"
FT REPEAT 568..601
FT /note="PC 5"
FT REPEAT 645..680
FT /note="PC 6"
FT REPEAT 681..715
FT /note="PC 7"
FT REPEAT 716..750
FT /note="PC 8"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 100251 MW; 75816FF842D13F19 CRC64;
MAQESDLSKT ADKGKGKAVD DEKKHQDVDG KTPANGKKEE EQNASEELSE EDQQLKSELE
MLVERLTESD ATLYKPALEA MKNSIKTSTS SMTAVPKPLK FLRPHYETMT KLYDEWPAGD
DKSSLADVLS VIGMTYSDED RQDTLKYRLL SPTQDIGSWG HEYVRHLALE IGEVYAKRIA
NDEPTQELVD LALVLVPLFL KSNAEADAVD LMSELEIIEE LPKFLDENTY SRVCLYMVSM
VNLLTYPDNE TFLRVAHSIY KKYNQHTQAM VLAIRLNDLG LIEKDFEAAD EDPALRKQLA
FLIARQGIPL EFERSNDDDE KIYECLSNQK LSEYFKSLGK ELNILEPKTT EDIYKSHLES
SRVAGMTNFD SARHNLAAGF VNAFVNAGFG SDKMMLVGKD KDSWVWKTKD EGMMSTVASL
GTLLLWDVEN GLDHVDKYTY LEEEQIQAGA YLAIGIMNTN VRTDSEPAMA LLADPDKLAH
KNPLIRVATI MGLGLAYAGS CKEELLSFLV NIISDPEESM QVSAMAALAC GMIFVGSSNS
EVSEAIVTTL LDEESGSRLN DKWSRFLALG LGLLYFGRQE QVDVILETLK AVEHPMAKPT
AVLAEICAWA GTGAVLKIQE LLHICNEHIE DGEEKKGEEL LQAYAVLGIG LIAMGEDVGQ
EMVLRHFGHL MHYGEANIRR AVPLAMGLIS PSNPQMKVYD TLSRYSHDND NEVAINAIFA
MGLLGAGTNN ARLAQLLRQL ASYYHRDQES LFMVRIAQGL LHMGKGTLSV SPFHTDRQVL
SNVATAGLLA VLVAMIDAKQ FITSKSHYLL YWIVTAMHPR MLVTLDEDLK PLTVNVRVGQ
AVDVVGQAGR PKTITGWQTQ STPVLLGYGE RAELEDDQYI SLSSTLEGLV ILRKNPDWEG
EK
