ID   RPN6_SCHPO              Reviewed;         421 AA.
AC   Q9P7S2;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Probable 26S proteasome regulatory subunit rpn6;
GN   Name=rpn6; ORFNames=SPAC23G3.11;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Component of the lid subcomplex of the 26S proteasome, a
CC       multiprotein complex involved in the ATP-dependent degradation of
CC       ubiquitinated proteins. In the complex, rpn6 is required for proteasome
CC       assembly (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the lid subcomplex of the 19S proteasome
CC       regulatory particle complex (also named PA700 complex). The 26S
CC       proteasome consists of a 20S proteasome core and two 19S regulatory
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S9 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB72236.1; -; Genomic_DNA.
DR   PIR; T50185; T50185.
DR   RefSeq; NP_593111.1; NM_001018508.2.
DR   AlphaFoldDB; Q9P7S2; -.
DR   SMR; Q9P7S2; -.
DR   BioGRID; 278298; 14.
DR   IntAct; Q9P7S2; 1.
DR   STRING; 4896.SPAC23G3.11.1; -.
DR   iPTMnet; Q9P7S2; -.
DR   MaxQB; Q9P7S2; -.
DR   PaxDb; Q9P7S2; -.
DR   PRIDE; Q9P7S2; -.
DR   EnsemblFungi; SPAC23G3.11.1; SPAC23G3.11.1:pep; SPAC23G3.11.
DR   GeneID; 2541807; -.
DR   KEGG; spo:SPAC23G3.11; -.
DR   PomBase; SPAC23G3.11; rpn6.
DR   VEuPathDB; FungiDB:SPAC23G3.11; -.
DR   eggNOG; KOG1463; Eukaryota.
DR   HOGENOM; CLU_029573_2_1_1; -.
DR   InParanoid; Q9P7S2; -.
DR   OMA; LYFDTGM; -.
DR   PhylomeDB; Q9P7S2; -.
DR   Reactome; R-SPO-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR   Reactome; R-SPO-174113; SCF-beta-TrCP mediated degradation of Emi1.
DR   Reactome; R-SPO-350562; Regulation of ornithine decarboxylase (ODC).
DR   Reactome; R-SPO-382556; ABC-family proteins mediated transport.
DR   Reactome; R-SPO-5668541; TNFR2 non-canonical NF-kB pathway.
DR   Reactome; R-SPO-5689603; UCH proteinases.
DR   Reactome; R-SPO-5689880; Ub-specific processing proteases.
DR   Reactome; R-SPO-6798695; Neutrophil degranulation.
DR   Reactome; R-SPO-68949; Orc1 removal from chromatin.
DR   Reactome; R-SPO-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   Reactome; R-SPO-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR   Reactome; R-SPO-75815; Ubiquitin-dependent degradation of Cyclin D.
DR   Reactome; R-SPO-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR   Reactome; R-SPO-8948751; Regulation of PTEN stability and activity.
DR   Reactome; R-SPO-8951664; Neddylation.
DR   Reactome; R-SPO-9755511; KEAP1-NFE2L2 pathway.
DR   Reactome; R-SPO-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR   Reactome; R-SPO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q9P7S2; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IDA:PomBase.
DR   GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR   GO; GO:0051306; P:mitotic sister chromatid separation; IC:PomBase.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IC:PomBase.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR040780; Rpn6_C_helix.
DR   InterPro; IPR040773; Rpn6_N.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF18503; RPN6_C_helix; 1.
DR   Pfam; PF18055; RPN6_N; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Proteasome; Reference proteome.
FT   CHAIN           1..421
FT                   /note="Probable 26S proteasome regulatory subunit rpn6"
FT                   /id="PRO_0000173859"
FT   DOMAIN          221..390
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   421 AA;  47341 MW;  A2FF8429385D9CE1 CRC64;
     MSSKSSLELA NNAVKSNDIE KAIDLYKEVL NKGVSKDEKV ANEQEQALTN LSDLYVRENR
     HNDLAQLVQQ SRPLMANFSK AKSAKIVRTL IDKFSGEKKS LPLQIEVAND CIKWAIKEKR
     TFLRQALETK LISLYYDNSS YTDAINLINT LLSELKRMDD KMLLTEVHLL ESKVYHAIRN
     IPKARASLTA AKTSANAVYC PPMLQGNLDL QSGILHADDM DFKTAYSYFY EAYEGFTSLD
     DDKKALSSLK YMLLSQIMLN SVSEVKSLLT GKHAIRYAGR DIEAMRAIAQ AHENRSLADF
     EKALQDYKPE LASDPIIRSH LSSLYDNLLE QNLLRVVEPF SRVEVSHIAE LIGLSTVQVE
     GKLSQMILDK IFYGILDQGS GCLIVYDEPQ QDKTYEAALE VIKNMGTVVD LLIENKASAL
     L