RPN8_ASHGO
ID RPN8_ASHGO Reviewed; 326 AA.
AC Q75F44;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=26S proteasome regulatory subunit RPN8;
GN Name=RPN8; OrderedLocusNames=AAL116W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase M67A family. {ECO:0000305}.
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DR EMBL; AE016814; AAS50250.1; -; Genomic_DNA.
DR RefSeq; NP_982426.1; NM_207779.1.
DR AlphaFoldDB; Q75F44; -.
DR SMR; Q75F44; -.
DR STRING; 33169.AAS50250; -.
DR MEROPS; M67.973; -.
DR EnsemblFungi; AAS50250; AAS50250; AGOS_AAL116W.
DR GeneID; 4618472; -.
DR KEGG; ago:AGOS_AAL116W; -.
DR eggNOG; KOG1556; Eukaryota.
DR HOGENOM; CLU_027018_3_0_1; -.
DR InParanoid; Q75F44; -.
DR OMA; HAMSIKT; -.
DR Proteomes; UP000000591; Chromosome I.
DR GO; GO:1990023; C:mitotic spindle midzone; IEA:EnsemblFungi.
DR GO; GO:0000502; C:proteasome complex; IBA:GO_Central.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:EnsemblFungi.
DR GO; GO:0034515; C:proteasome storage granule; IEA:EnsemblFungi.
DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd08062; MPN_RPN7_8; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR033858; MPN_RPN7_8.
DR InterPro; IPR024969; Rpn11/EIF3F_C.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF13012; MitMem_reg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Proteasome; Reference proteome.
FT CHAIN 1..326
FT /note="26S proteasome regulatory subunit RPN8"
FT /id="PRO_0000213947"
FT DOMAIN 8..143
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT REGION 299..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 326 AA; 36572 MW; 3CEC9B0E7515EBD2 CRC64;
MSVNYEQVNV APLVLLSVLD HYKRMNTPDN KRCVGVLLGD NSGSTIKVTN SFALPFEEDE
KNPDVWFLDH NYIENMNDMC KKINAKEKMI GWYHSGPKLR SSDLKINGLF KKYTQGNSLL
LIVDVKQQGV GLPTDAYMAI EEVKDDGSST ERTFVHLPTA IEAEEAEEIG VEHLLRDVRD
QAAGNLSLRL TNQLKSLQGL QRKLRDIVAY LDKVNSGQLP ANHIILGKLQ DVFNLLPNLG
SPDEEAPATK KDDVLASSNT LQKALTVKTN DELMVIYISN LMRAIIAFDN LIENKIKNKK
LQEAKRDPEP EEATKEEIQQ QESAKA
