ID   RPN8_CANGA              Reviewed;         329 AA.
AC   Q6FMD8;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=26S proteasome regulatory subunit RPN8;
GN   Name=RPN8; OrderedLocusNames=CAGL0K08866g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M67A family. {ECO:0000305}.
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DR   EMBL; CR380957; CAG61569.1; -; Genomic_DNA.
DR   RefSeq; XP_448606.1; XM_448606.1.
DR   AlphaFoldDB; Q6FMD8; -.
DR   SMR; Q6FMD8; -.
DR   STRING; 5478.XP_448606.1; -.
DR   MEROPS; M67.973; -.
DR   EnsemblFungi; CAG61569; CAG61569; CAGL0K08866g.
DR   GeneID; 2890288; -.
DR   KEGG; cgr:CAGL0K08866g; -.
DR   CGD; CAL0134055; CAGL0K08866g.
DR   VEuPathDB; FungiDB:CAGL0K08866g; -.
DR   eggNOG; KOG1556; Eukaryota.
DR   HOGENOM; CLU_027018_3_0_1; -.
DR   InParanoid; Q6FMD8; -.
DR   OMA; HAMSIKT; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:1990023; C:mitotic spindle midzone; IEA:EnsemblFungi.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:EnsemblFungi.
DR   GO; GO:0034515; C:proteasome storage granule; IEA:EnsemblFungi.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR   CDD; cd08062; MPN_RPN7_8; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR033858; MPN_RPN7_8.
DR   InterPro; IPR024969; Rpn11/EIF3F_C.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF13012; MitMem_reg; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Proteasome; Reference proteome.
FT   CHAIN           1..329
FT                   /note="26S proteasome regulatory subunit RPN8"
FT                   /id="PRO_0000213948"
FT   DOMAIN          8..143
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   REGION          303..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  37148 MW;  58ED7BCAE192AA60 CRC64;
     MSLHHDNVTI APLVLLSVLD HYERTNTPEG KRCVGVILGD SQTNTIRVTN SFALPFEEDE
     KNSDVWFLDH NYIESMNEMC KKINAKEKLI GWYHSGPKLR ASDLKINELF KKYTQGNPLL
     LIVDVKQQDV GLPTDAYMAV EQVKDDGTST EKTFLHLPCT VEAEEAEEIG VEHLLRDVRD
     QAAGGLSIRL TNQLKSLKGL QKKLNDIVIY LNKVINNELP VNHTILGKLQ DVFNLLPNLG
     YNEETDVSAT SNDMVTASNN LQRALTVKTN DELMVIYITN LVRAIIAFDD LIENKMQNKK
     LQEERNKELQ ADINKVESET AETEKVATD