RPO1C_THEAC
ID RPO1C_THEAC Reviewed; 508 AA.
AC Q03586;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=DNA-directed RNA polymerase subunit Rpo1C {ECO:0000255|HAMAP-Rule:MF_00411};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_00411};
DE AltName: Full=DNA-directed RNA polymerase subunit A'' {ECO:0000255|HAMAP-Rule:MF_00411};
GN Name=rpo1C {ECO:0000255|HAMAP-Rule:MF_00411};
GN Synonyms=rpoA2 {ECO:0000255|HAMAP-Rule:MF_00411}; OrderedLocusNames=Ta0392;
OS Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS 15155 / AMRC-C165).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273075;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX PubMed=1408839; DOI=10.1093/nar/20.19.5226;
RA Klenk H.-P., Renner O., Schwass V., Zillig W.;
RT "Nucleotide sequence of the genes encoding the subunits H, B, A' and A'' of
RT the DNA-dependent RNA polymerase and the initiator tRNA from Thermoplasma
RT acidophilum.";
RL Nucleic Acids Res. 20:5226-5226(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX PubMed=11029001; DOI=10.1038/35035069;
RA Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT acidophilum.";
RL Nature 407:508-513(2000).
CC -!- FUNCTION: DNA-dependent RNA polymerase (RNAP) catalyzes the
CC transcription of DNA into RNA using the four ribonucleoside
CC triphosphates as substrates. Forms part of the jaw domain.
CC {ECO:0000255|HAMAP-Rule:MF_00411}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_00411};
CC -!- SUBUNIT: Part of the RNA polymerase complex. {ECO:0000255|HAMAP-
CC Rule:MF_00411}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00411}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000255|HAMAP-Rule:MF_00411}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC11536.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; X68198; CAA48282.1; -; Genomic_DNA.
DR EMBL; AL445064; CAC11536.1; ALT_INIT; Genomic_DNA.
DR PIR; S26724; S26724.
DR RefSeq; WP_048162261.1; NC_002578.1.
DR AlphaFoldDB; Q03586; -.
DR SMR; Q03586; -.
DR STRING; 273075.Ta0392; -.
DR EnsemblBacteria; CAC11536; CAC11536; CAC11536.
DR GeneID; 1456008; -.
DR KEGG; tac:Ta0392; -.
DR eggNOG; arCOG04256; Archaea.
DR HOGENOM; CLU_037097_1_0_2; -.
DR OMA; TPMMTVY; -.
DR OrthoDB; 66811at2157; -.
DR Proteomes; UP000001024; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd06528; RNAP_A; 1.
DR HAMAP; MF_00411; RNApol_arch_Rpo1C; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR012757; RPO1C.
DR PANTHER; PTHR19376; PTHR19376; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR TIGRFAMs; TIGR02389; RNA_pol_rpoA2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; DNA-binding;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..508
FT /note="DNA-directed RNA polymerase subunit Rpo1C"
FT /id="PRO_0000074028"
FT REGION 1..123
FT /note="Unknown"
FT REGION 124..508
FT /note="DNA-directed RNA polymerase subunit Rpo1C"
SQ SEQUENCE 508 AA; 56599 MW; 1599FAF94897CA4C CRC64;
MASLLWRDTS KNIAAILEKL PADYAVDYDV PNNVEDGYIT INKKNFTYHV VISGVRKYSP
DVEAIVKKKS GLKSIITIEK VEKIEPLSFM EFRVGGKTLE AMGSFEVAER QVTEIKEKYG
ENLSEDVQKV LDDARAMGFT LPESVAEEIA RRRTEWGEKA YKNILKRIGE EIGNELIDPY
EAVGIIAAQS IGEPGTQMTM RTFHFAGVRE MNVTLGLPRL IEIVDARRIP STPSMTIYLR
PEYETNDEVV MDVVKRLENT SISDVADIIT DIGELTVTVR PDPRKTKDRL IEMEDIMNAI
SKIKGITVME DSGQIIIKPQ QESFKKLYLL QEQIKGLTIK GISGIKRAIA RVEGKEHRWV
IYTQGSNLKD VLEVDEVDPT RTYTNDIVEI ANVLGIEAAR NAILNEALRT LQEQGLNVDV
RHLMLVADMM TFSGSVRAVG RTGISGRKSS VLARAAFEIT TKHLLRAGIM GEVDKLAGVA
ENIIVGQPIT LGTGAVDIIY KGYPKTKK
