AB33G_ARATH
ID AB33G_ARATH Reviewed; 1413 AA.
AC Q9ZUT8;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=ABC transporter G family member 33;
DE Short=ABC transporter ABCG.33;
DE Short=AtABCG33;
DE AltName: Full=Pleiotropic drug resistance protein 5;
GN Name=ABCG33; Synonyms=PDR5; OrderedLocusNames=At2g37280; ORFNames=F3G5.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP IDENTIFICATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=12430018; DOI=10.1007/s00425-002-0889-z;
RA van den Brule S., Smart C.C.;
RT "The plant PDR family of ABC transporters.";
RL Planta 216:95-106(2002).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and stems.
CC {ECO:0000269|PubMed:12430018}.
CC -!- INDUCTION: Induced by 2,4-D, but repressed by cycloheximide (CHX).
CC {ECO:0000269|PubMed:12430018}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR EMBL; AC005896; AAC98048.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09377.1; -; Genomic_DNA.
DR EMBL; BK001004; DAA00873.1; -; Genomic_DNA.
DR PIR; G84790; G84790.
DR RefSeq; NP_181265.1; NM_129284.2.
DR AlphaFoldDB; Q9ZUT8; -.
DR SMR; Q9ZUT8; -.
DR STRING; 3702.AT2G37280.1; -.
DR iPTMnet; Q9ZUT8; -.
DR MetOSite; Q9ZUT8; -.
DR PaxDb; Q9ZUT8; -.
DR PRIDE; Q9ZUT8; -.
DR ProteomicsDB; 244531; -.
DR EnsemblPlants; AT2G37280.1; AT2G37280.1; AT2G37280.
DR GeneID; 818305; -.
DR Gramene; AT2G37280.1; AT2G37280.1; AT2G37280.
DR KEGG; ath:AT2G37280; -.
DR Araport; AT2G37280; -.
DR TAIR; locus:2049867; AT2G37280.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_6_1; -.
DR InParanoid; Q9ZUT8; -.
DR PhylomeDB; Q9ZUT8; -.
DR PRO; PR:Q9ZUT8; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZUT8; baseline and differential.
DR Genevisible; Q9ZUT8; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1413
FT /note="ABC transporter G family member 33"
FT /id="PRO_0000234632"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 580..600
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 626..646
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 652..672
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 738..758
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1157..1177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1189..1209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1245..1265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1276..1296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1302..1322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1330..1350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1385..1405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 140..412
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 490..702
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 813..1065
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1138..1352
FT /note="ABC transmembrane type-2 2"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 172..179
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 858..865
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1413 AA; 160252 MW; 581296C1368E1BE3 CRC64;
MGSSFRSSSS RNEHEDGGDE AEHALQWAEI QRLPTFKRLR SSLVDKYGEG TEKGKKVVDV
TKLGAMERHL MIEKLIKHIE NDNLKLLKKI RRRMERVGVE FPSIEVRYEH LGVEAACEVV
EGKALPTLWN SLKHVFLDLL KLSGVRTNEA NIKILTDVSG IISPGRLTLL LGPPGCGKTT
LLKALSGNLE NNLKCYGEIS YNGHGLNEVV PQKTSAYISQ HDLHIAEMTT RETIDFSARC
QGVGSRTDIM MEVSKREKDG GIIPDPEIDA YMKAISVKGL KRSLQTDYIL KILGLDICAE
TLVGNAMKRG ISGGQKKRLT TAEMIVGPTK ALFMDEITNG LDSSTAFQII KSLQQVAHIT
NATVFVSLLQ PAPESYDLFD DIVLMAEGKI VYHGPRDDVL KFFEECGFQC PERKGVADFL
QEVISKKDQG QYWLHQNLPH SFVSVDTLSK RFKDLEIGRK IEEALSKPYD ISKTHKDALS
FNVYSLPKWE LFRACISREF LLMKRNYFVY LFKTFQLVLA AIITMTVFIR TRMDIDIIHG
NSYMSCLFFA TVVLLVDGIP ELSMTVQRLS VFYKQKQLCF YPAWAYAIPA TVLKIPLSFF
ESLVWTCLTY YVIGYTPEPY RFFRQFMILF AVHFTSISMF RCIAAIFQTG VAAMTAGSFV
MLITFVFAGF AIPYTDMPGW LKWGFWVNPI SYAEIGLSVN EFLAPRWQKM QPTNVTLGRT
ILESRGLNYD DYMYWVSLSA LLGLTIIFNT IFTLALSFLK SPTSSRPMIS QDKLSELQGT
KDSSVKKNKP LDSSIKTNED PGKMILPFKP LTITFQDLNY YVDVPVEMKG QGYNEKKLQL
LSEITGAFRP GVLTALMGIS GAGKTTLLDV LAGRKTSGYI EGEIRISGFL KVQETFARVS
GYCEQTDIHS PSITVEESLI YSAWLRLVPE INPQTKIRFV KQVLETIELE EIKDALVGVA
GVSGLSTEQR KRLTVAVELV ANPSIIFMDE PTTGLDARAA AIVMRAVKNV AETGRTIVCT
IHQPSIHIFE AFDELVLLKR GGRMIYSGPL GQHSSCVIEY FQNIPGVAKI RDKYNPATWM
LEVTSESVET ELDMDFAKIY NESDLYKNNS ELVKELSKPD HGSSDLHFKR TFAQNWWEQF
KSCLWKMSLS YWRSPSYNLM RIGHTFISSF IFGLLFWNQG KKIDTQQNLF TVLGAIYGLV
LFVGINNCTS ALQYFETERN VMYRERFAGM YSAFAYALAQ VVTEIPYIFI QSAEFVIVIY
PMIGFYASFS KVFWSLYAMF CNLLCFNYLA MFLISITPNF MVAAILQSLF FTTFNIFAGF
LIPKPQIPKW WVWFYYITPT SWTLNLFFSS QYGDIHQKIN AFGETKTVAS FLEDYFGFHH
DRLMITAIIL IAFPIALATM YAFFVAKLNF QKR
