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RPOA1_FRATH
ID   RPOA1_FRATH             Reviewed;         323 AA.
AC   Q2A5E5;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA-directed RNA polymerase subunit alpha 1 {ECO:0000255|HAMAP-Rule:MF_00059};
DE            Short=RNAP subunit alpha 1 {ECO:0000255|HAMAP-Rule:MF_00059};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_00059};
DE   AltName: Full=RNA polymerase subunit alpha 1 {ECO:0000255|HAMAP-Rule:MF_00059};
DE   AltName: Full=Transcriptase subunit alpha 1 {ECO:0000255|HAMAP-Rule:MF_00059};
GN   Name=rpoA1 {ECO:0000255|HAMAP-Rule:MF_00059}; OrderedLocusNames=FTL_0261;
OS   Francisella tularensis subsp. holarctica (strain LVS).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=376619;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVS;
RA   Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S.,
RA   Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R.,
RA   Garcia E.;
RT   "Complete genome sequence of Francisella tularensis LVS (Live Vaccine
RT   Strain).";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_00059}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_00059};
CC   -!- SUBUNIT: Homodimer. The RNAP catalytic core consists of 2 alpha, 1
CC       beta, 1 beta' and 1 omega subunit. When a sigma factor is associated
CC       with the core the holoenzyme is formed, which can initiate
CC       transcription. {ECO:0000255|HAMAP-Rule:MF_00059}.
CC   -!- DOMAIN: The N-terminal domain is essential for RNAP assembly and basal
CC       transcription, whereas the C-terminal domain is involved in interaction
CC       with transcriptional regulators and with upstream promoter elements.
CC       {ECO:0000255|HAMAP-Rule:MF_00059}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase alpha chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_00059}.
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DR   EMBL; AM233362; CAJ78702.1; -; Genomic_DNA.
DR   RefSeq; WP_003021582.1; NZ_CP009694.1.
DR   PDB; 6WMP; EM; 2.98 A; A=1-323.
DR   PDB; 6WMR; EM; 3.46 A; A=1-323.
DR   PDB; 6WMT; EM; 4.43 A; A=1-323.
DR   PDBsum; 6WMP; -.
DR   PDBsum; 6WMR; -.
DR   PDBsum; 6WMT; -.
DR   AlphaFoldDB; Q2A5E5; -.
DR   SMR; Q2A5E5; -.
DR   KEGG; ftl:FTL_0261; -.
DR   OMA; LMKFRNF; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.170.120.12; -; 1.
DR   Gene3D; 3.30.1360.10; -; 1.
DR   HAMAP; MF_00059; RNApol_bact_RpoA; 1.
DR   InterPro; IPR011262; DNA-dir_RNA_pol_insert.
DR   InterPro; IPR011263; DNA-dir_RNA_pol_RpoA/D/Rpb3.
DR   InterPro; IPR011773; DNA-dir_RpoA.
DR   InterPro; IPR036603; RBP11-like.
DR   InterPro; IPR011260; RNAP_asu_C.
DR   InterPro; IPR036643; RNApol_insert_sf.
DR   PANTHER; PTHR32108; PTHR32108; 1.
DR   Pfam; PF01000; RNA_pol_A_bac; 1.
DR   Pfam; PF03118; RNA_pol_A_CTD; 1.
DR   Pfam; PF01193; RNA_pol_L; 1.
DR   SMART; SM00662; RPOLD; 1.
DR   SUPFAM; SSF55257; SSF55257; 1.
DR   SUPFAM; SSF56553; SSF56553; 1.
DR   TIGRFAMs; TIGR02027; rpoA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-directed RNA polymerase; Nucleotidyltransferase;
KW   Transcription; Transferase.
FT   CHAIN           1..323
FT                   /note="DNA-directed RNA polymerase subunit alpha 1"
FT                   /id="PRO_0000296802"
FT   REGION          1..228
FT                   /note="Alpha N-terminal domain (alpha-NTD)"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00059"
FT   REGION          244..323
FT                   /note="Alpha C-terminal domain (alpha-CTD)"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00059"
FT   TURN            21..23
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          27..32
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          34..36
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   HELIX           37..51
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          54..62
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          66..69
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          75..78
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   HELIX           79..82
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   TURN            83..87
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          99..101
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          104..106
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          109..113
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   HELIX           114..116
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          131..137
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          141..143
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          146..150
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          155..157
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          165..170
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          178..187
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          189..200
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   STRAND          202..204
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   HELIX           206..221
FT                   /evidence="ECO:0007829|PDB:6WMP"
FT   TURN            222..226
FT                   /evidence="ECO:0007829|PDB:6WMP"
SQ   SEQUENCE   323 AA;  35358 MW;  D9F934544A63E27F CRC64;
     MSNNNSKLEF VPNIQLKEDL GAFSYKVQLS PVEKGMAHIL GNSIRRVLLS SLSGASIIKV
     NIANVLHEYS TLEDVKEDVV EIVSNLKKVA IKLDTGIDRL DLELSVNKSG VVSAGDFKTT
     QGVEIINKDQ PIATLTNQRA FSLTATVSVG RNVGILSAIP TELERVGDIA VDADFNPIKR
     VAFEVFDNGD SETLEVFVKT NGTIEPLAAV TKALEYFCEQ ISVFVSLRVP SNGKTGDVLI
     DSNIDPILLK PIDDLELTVR SSNCLRAENI KYLGDLVQYS ESQLMKIPNL GKKSLNEIKQ
     ILIDNNLSLG VQIDNFRELV EGK
 
 
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