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ATPZ_ECOLI
ID   ATPZ_ECOLI              Reviewed;         126 AA.
AC   P0ABC0; P03808; P76747; Q2M857; Q47248;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=ATP synthase protein I;
GN   Name=atpI; Synonyms=uncI; OrderedLocusNames=b3739, JW5611;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6395859; DOI=10.1042/bj2240799;
RA   Walker J.E., Gay N.J., Saraste M., Eberle A.N.;
RT   "DNA sequence around the Escherichia coli unc operon. Completion of the
RT   sequence of a 17 kilobase segment containing asnA, oriC, unc, glmS and
RT   phoS.";
RL   Biochem. J. 224:799-815(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6272190; DOI=10.1093/nar/9.16.3919;
RA   Gay N.J., Walker J.E.;
RT   "The atp operon: nucleotide sequence of the promoter and the genes for the
RT   membrane proteins, and the delta subunit of Escherichia coli ATP-
RT   synthase.";
RL   Nucleic Acids Res. 9:3919-3926(1981).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6206892; DOI=10.1016/0304-4173(84)90003-x;
RA   Walker J.E., Saraste M., Gay N.J.;
RT   "The unc operon. Nucleotide sequence, regulation and structure of ATP-
RT   synthase.";
RL   Biochim. Biophys. Acta 768:164-200(1984).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=6318052; DOI=10.1007/bf00327415;
RA   Nielsen J., Joergensen B.B., von Meyenburg K., Hansen F.G.;
RT   "The promoters of the atp operon of Escherichia coli K12.";
RL   Mol. Gen. Genet. 193:64-71(1984).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6301339; DOI=10.1111/j.1749-6632.1982.tb25731.x;
RA   Kanazawa H., Futai M.;
RT   "Structure and function of H+-ATPase: what we have learned from Escherichia
RT   coli H+-ATPase.";
RL   Ann. N. Y. Acad. Sci. 402:45-64(1982).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7686882; DOI=10.1006/geno.1993.1230;
RA   Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.;
RT   "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome:
RT   organizational symmetry around the origin of replication.";
RL   Genomics 16:551-561(1993).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-108.
RX   PubMed=6327640; DOI=10.1128/jb.158.3.820-825.1984;
RA   Gay N.J.;
RT   "Construction and characterization of an Escherichia coli strain with a
RT   uncI mutation.";
RL   J. Bacteriol. 158:820-825(1984).
RN   [10]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80.
RX   PubMed=6215041; DOI=10.1016/0006-291x(82)91529-7;
RA   Kanazawa H., Mabuchi K., Futai M.;
RT   "Nucleotide sequence of the promoter region of the gene cluster for proton-
RT   translocating ATPase from Escherichia coli and identification of the active
RT   promotor.";
RL   Biochem. Biophys. Res. Commun. 107:568-575(1982).
RN   [11]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-126.
RX   PubMed=6278247; DOI=10.1007/bf00271191;
RA   Nielsen J., Hansen F.G., Hoppe J., Friedl P., von Meyenburg K.;
RT   "The nucleotide sequence of the atp genes coding for the F0 subunits a, b,
RT   c and the F1 subunit delta of the membrane bound ATP synthase of
RT   Escherichia coli.";
RL   Mol. Gen. Genet. 184:33-39(1981).
RN   [12]
RP   PROTEIN SEQUENCE OF 2-8.
RX   PubMed=2136739; DOI=10.1016/s0021-9258(19)40242-1;
RA   Schneppe B., Deckers-Hebesteit G., Altendorf K.;
RT   "Overproduction and purification of the uncI gene product of the ATP
RT   synthase of Escherichia coli.";
RL   J. Biol. Chem. 265:389-395(1990).
RN   [13]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- FUNCTION: A possible function for this protein is to guide the assembly
CC       of the membrane sector of the ATPase enzyme complex.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the bacterial AtpI family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA24730.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAA62091.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAA83868.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAA23513.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAA25640.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAA25775.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; X01631; CAA25775.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X01383; CAA25640.1; ALT_INIT; Genomic_DNA.
DR   EMBL; V00264; CAA23513.1; ALT_INIT; Genomic_DNA.
DR   EMBL; J01594; AAA24730.1; ALT_INIT; Genomic_DNA.
DR   EMBL; M25464; AAA83868.1; ALT_INIT; Genomic_DNA.
DR   EMBL; L10328; AAA62091.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC76762.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77549.1; -; Genomic_DNA.
DR   RefSeq; NP_418195.2; NC_000913.3.
DR   RefSeq; WP_000116695.1; NZ_SSZK01000036.1.
DR   AlphaFoldDB; P0ABC0; -.
DR   BioGRID; 4259565; 5.
DR   STRING; 511145.b3739; -.
DR   PaxDb; P0ABC0; -.
DR   PRIDE; P0ABC0; -.
DR   EnsemblBacteria; AAC76762; AAC76762; b3739.
DR   EnsemblBacteria; BAE77549; BAE77549; BAE77549.
DR   GeneID; 66672357; -.
DR   GeneID; 948251; -.
DR   KEGG; ecj:JW5611; -.
DR   KEGG; eco:b3739; -.
DR   PATRIC; fig|1411691.4.peg.2961; -.
DR   EchoBASE; EB0104; -.
DR   eggNOG; COG3312; Bacteria.
DR   HOGENOM; CLU_121415_2_0_6; -.
DR   OMA; YMYMQVE; -.
DR   PhylomeDB; P0ABC0; -.
DR   BioCyc; EcoCyc:EG10106-MON; -.
DR   PRO; PR:P0ABC0; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005598; ATP_synth_I.
DR   Pfam; PF03899; ATP-synt_I; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; CF(0); Direct protein sequencing;
KW   Hydrogen ion transport; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:2136739"
FT   CHAIN           2..126
FT                   /note="ATP synthase protein I"
FT                   /id="PRO_0000071706"
FT   TOPO_DOM        2..14
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..37
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..70
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        95..100
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..126
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        37
FT                   /note="G -> A (in Ref. 5; AAA83868)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   126 AA;  13632 MW;  308FC1C16059C5A6 CRC64;
     MSVSLVSRNV ARKLLLVQLL VVIASGLLFS LKDPFWGVSA ISGGLAVFLP NVLFMIFAWR
     HQAHTPAKGR VAWTFAFGEA FKVLAMLVLL VVALAVLKAV FLPLIVTWVL VLVVQILAPA
     VINNKG
 
 
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