ATR11_STAC4
ID ATR11_STAC4 Reviewed; 133 AA.
AC A0A084R1N8;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 29-OCT-2014, sequence version 1.
DT 25-MAY-2022, entry version 13.
DE RecName: Full=Core atranone cluster (CAC) protein 11 {ECO:0000303|PubMed:25015739};
GN Name=ATR11 {ECO:0000303|PubMed:25015739}; ORFNames=S40285_10096;
OS Stachybotrys chlorohalonata (strain IBT 40285).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Stachybotryaceae; Stachybotrys.
OX NCBI_TaxID=1283841;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION, AND
RP FUNCTION.
RC STRAIN=IBT 40285;
RX PubMed=25015739; DOI=10.1186/1471-2164-15-590;
RA Semeiks J., Borek D., Otwinowski Z., Grishin N.V.;
RT "Comparative genome sequencing reveals chemotype-specific gene clusters in
RT the toxigenic black mold Stachybotrys.";
RL BMC Genomics 15:590-590(2014).
CC -!- FUNCTION: Part of the core atranone cluster (CAC) which products are
CC predicted to catalyze most or all steps of mycotoxin atranone
CC synthesis, starting from geranylgeranyl pyrophosphate (GGPP)
CC (PubMed:25015739). The initial cyclization of GGPP to dolabellane is
CC probably performed by the terpene cyclase ATR13 (PubMed:25015739). The
CC Baeyer-Villiger oxidation near the end of the atranone synthesis, which
CC converts atranones D and E to atranones F and G is predicted to be
CC catalyzed by the monooxygenase ATR8 (PubMed:25015739). Of the CAC's
CC other predicted gene products, the reducing PKS ATR6 might synthesize a
CC polyketide chain (PubMed:25015739). This polyketide is probably
CC transferred onto the atranone backbone by the polyketide transferase
CC ATR5 (By similarity). Other predicted CAC products include 4 oxygenases
CC (ATR2, ATR3, ATR4, and ATR14), 3 short-chain reductases (ATR7, ATR9,
CC and ATR10), and a methyltransferase (ATR12) (PubMed:25015739). These
CC may all be involved in the various steps of atranone biosynthesis,
CC although their specific roles must await experimental determination
CC (PubMed:25015739). {ECO:0000250|UniProtKB:Q4WAY4,
CC ECO:0000305|PubMed:25015739}.
CC -!- PATHWAY: Mycotoxin biosynthesis. {ECO:0000305|PubMed:25015739}.
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DR EMBL; KL659308; KFA70123.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084R1N8; -.
DR SMR; A0A084R1N8; -.
DR EnsemblFungi; KFA70123; KFA70123; S40285_10096.
DR HOGENOM; CLU_1908077_0_0_1; -.
DR OMA; VVMFAHA; -.
DR OrthoDB; 1409451at2759; -.
DR Proteomes; UP000028524; Unassembled WGS sequence.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR SUPFAM; SSF54427; SSF54427; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..133
FT /note="Core atranone cluster (CAC) protein 11"
FT /id="PRO_0000442390"
SQ SEQUENCE 133 AA; 15259 MW; D80AD3D14C8139FA CRC64;
MASRKATVQS IVESFNERDI DKMTAPVSKN FVYQLLPKSL ERGPMDVAGF RGLFEATKSY
FNNFKFEVVD TFEDSAADKM ILWANVTSDT HVGKFATEVM LIFYFDTTGK IYKWIEWIDS
AVGKEFEQKL QGQ