ID   ATR13_STAC4             Reviewed;         381 AA.
AC   A0A084R1K7;
DT   22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Terpene cyclase ATR13 {ECO:0000303|PubMed:25015739};
DE            EC=4.2.3.- {ECO:0000305|PubMed:25015739};
DE   AltName: Full=Core atranone cluster (CAC) protein 13 {ECO:0000303|PubMed:25015739};
GN   Name=ATR13 {ECO:0000303|PubMed:25015739}; ORFNames=S40285_03337;
OS   Stachybotrys chlorohalonata (strain IBT 40285).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Stachybotryaceae; Stachybotrys.
OX   NCBI_TaxID=1283841;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION, AND
RP   FUNCTION.
RC   STRAIN=IBT 40285;
RX   PubMed=25015739; DOI=10.1186/1471-2164-15-590;
RA   Semeiks J., Borek D., Otwinowski Z., Grishin N.V.;
RT   "Comparative genome sequencing reveals chemotype-specific gene clusters in
RT   the toxigenic black mold Stachybotrys.";
RL   BMC Genomics 15:590-590(2014).
CC   -!- FUNCTION: Terpene cyclase; part of the core atranone cluster (CAC)
CC       which products are predicted to catalyze most or all steps of mycotoxin
CC       atranone synthesis, starting from geranylgeranyl pyrophosphate (GGPP)
CC       (PubMed:25015739). The initial cyclization of GGPP to dolabellane is
CC       probably performed by the terpene cyclase ATR13 (PubMed:25015739). The
CC       Baeyer-Villiger oxidation near the end of the atranone synthesis, which
CC       converts atranones D and E to atranones F and G is predicted to be
CC       catalyzed by the monooxygenase ATR8 (PubMed:25015739). Of the CAC's
CC       other predicted gene products, the reducing PKS ATR6 might synthesize a
CC       polyketide chain (PubMed:25015739). This polyketide is probably
CC       transferred onto the atranone backbone by the polyketide transferase
CC       ATR5 (By similarity). Other predicted CAC products include 4 oxygenases
CC       (ATR2, ATR3, ATR4, and ATR14), 3 short-chain reductases (ATR7, ATR9,
CC       and ATR10), and a methyltransferase (ATR12) (PubMed:25015739). These
CC       may all be involved in the various steps of atranone biosynthesis,
CC       although their specific roles must await experimental determination
CC       (PubMed:25015739). {ECO:0000250|UniProtKB:Q4WAY4,
CC       ECO:0000305|PubMed:25015739}.
CC   -!- PATHWAY: Mycotoxin biosynthesis. {ECO:0000305|PubMed:25015739}.
CC   -!- SIMILARITY: Belongs to the terpene synthase family. {ECO:0000305}.
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DR   EMBL; KL659308; KFA70092.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A084R1K7; -.
DR   SMR; A0A084R1K7; -.
DR   STRING; 1283841.A0A084R1K7; -.
DR   EnsemblFungi; KFA70092; KFA70092; S40285_03337.
DR   HOGENOM; CLU_042677_0_0_1; -.
DR   OMA; YLEFRIL; -.
DR   OrthoDB; 1143139at2759; -.
DR   Proteomes; UP000028524; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.600.10; -; 1.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   SUPFAM; SSF48576; SSF48576; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..381
FT                   /note="Terpene cyclase ATR13"
FT                   /id="PRO_0000442412"
SQ   SEQUENCE   381 AA;  43218 MW;  B17B12AFFD7A3901 CRC64;
     MALEEISERL QVSDFPTLGM AANYDLRRHK FESLANDGSH EMRADVRRWV GNPSDFGGCN
     PINGHIIALT MPMIKPDRVK IAGYIYECWF LYSWDLTTTL TGADGFFHDD ILEGTNEGVS
     DTDAFGLGTA DQDAKARDGR KQIQAKMMYL LETTDKACAK HLQKVWSNML VTTIQHKSRD
     FETLKEYIDF RIRDCGALFG EGVMLFGMGL ALTEKDREDV ASTIYPCYAA LGLTNDYFSF
     DREWEEAKRT GEAKFSNAVR LFMDWQSTGA AAAKEVVRKA IIEYEREFLE LREKFVKANP
     KAERLHKFLE AMVYQISGHV VWSINCPRYN PSFRYDPNSG VENQVLAERR GKSSSKKPSV
     MIEEIDEKSH LASETGPAMI A