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RPOB_ACIF5
ID   RPOB_ACIF5              Reviewed;        1362 AA.
AC   B5ELX2;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Lferr_0490;
OS   Acidithiobacillus ferrooxidans (strain ATCC 53993 / BNL-5-31)
OS   (Leptospirillum ferrooxidans (ATCC 53993)).
OC   Bacteria; Proteobacteria; Acidithiobacillia; Acidithiobacillales;
OC   Acidithiobacillaceae; Acidithiobacillus.
OX   NCBI_TaxID=380394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 53993 / BNL-5-31;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA   Borole A.P.;
RT   "Complete sequence of Acidithiobacillus ferrooxidans ATCC 53993.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; CP001132; ACH82744.1; -; Genomic_DNA.
DR   RefSeq; WP_012536082.1; NC_011206.1.
DR   AlphaFoldDB; B5ELX2; -.
DR   SMR; B5ELX2; -.
DR   GeneID; 66431376; -.
DR   KEGG; afe:Lferr_0490; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_1_6; -.
DR   OMA; FMTWEGY; -.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 1.
DR   Gene3D; 2.40.50.150; -; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW   Transferase.
FT   CHAIN           1..1362
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_1000141653"
SQ   SEQUENCE   1362 AA;  151762 MW;  3B84E808D646ADB5 CRC64;
     MAYSFTEKKR IRKDFGKSQS ILAVPYLLAT QMDSYREFLQ ESVPPAARKE TGLEAVFRSV
     FPMESYSGNA MLDYVSYRLE KPVFDVVECR QRGLTYCAGL RVRLRLAVME KDDTTGAKRV
     KDVKEQDVYM GELPLMTEHG SFVINGTERV IVSQLHRSPG VFFDHDRGKT HSSGKLLFNA
     RIIPYRGSWL DFEFDPKDHV YARIDRRRKL PATTLLRALG YSTQDILEMF FDMETFRLID
     GDLRYVLIPQ RLQGEVAAFD IVSPETGDVL VQAGKRITVR QTKALSEVQG LHEIPVPDSF
     LLGKVVARDI VHPETGEVVV QANEPVSGEL LDALRKMPSL TLHTLYLNEL DRGPYISETL
     RIDTSRDAHD AQMEIYRLMR PGEPPTKDAA QNLFQGLFFS PDRYDLSAVG RMKFNRRVGR
     DEITGPGVLN DADIIAVLKV LVALRNGVGE IDDIDHLGNR RVRSVGELME NQFRLGLVRV
     ERAVKDRLAL AESEGLTPQD LINAKPIAAV VNEFFGSSQL SQFMDQTNPL SEVTHKRRVS
     ALGPGGLTRE RAGFEVRDVH PTHYGRICPI ETPEGPNIGL INSLSCYART NSYGFLETPY
     RRVVDRRTTD EVEYLSAIEE GNYMIAQANS TVDEHGVLTD ELVSCRFKNE FTLANPDQVQ
     FMDISPRQIV SVAASMIPFL EHDDANRALM GSNMQRQAVP TVRSDAPMVG TGMERVVAID
     SGAAVVARRG GVVDIVDGAR IVIRVSDEET LPEEPGVDIY NLVKYARSNQ NTTLNQRPVV
     KVGDVVSRGD VLADGPSTEM GELALGQNIL VAFMPWNGYN FEDSILISER VVAEDRYTTI
     HIEEFSVFAR DTKLGPEEIT RDIPNVAEGA LRHLDESGIV VIGAELAPGD ILVGKVTPKG
     ETQLTPEEKL LRAIFGEKAS DVKDNSMRMP AGMYGTVIDV QVFTRDGIEK DARAKSIEEH
     ELARIRKDLN DQYRIVEEDS YQRIERQLIG KVAEGGPNGL AAGNKVTKAY LKDLPRAKWF
     EIRLRTEESN ESLEQIRAQL EEQRQRLDAV LEEKRRKLTQ GDDLSPGVLK MVKVHVAIKR
     HLQPGDKMAG RHGNKGVVSK IVPVEDMPYL ADGTAVDIVL NPLGVPSRMN VGQILETHLG
     WAAKGLGKKI GAMLDSEVAM AEMRAFLAEI YNRSGKKEDL DSLTDQEIRE LSANLRGGVP
     MATPVFDGAS EEEIGDMLEL AGLPRSGQVT LYDGRSGDAF DRPVTVGYLY MLKLHHLVDD
     KMHARSTGPY SLVTQQPLGG KAQFGGQRFG EMEVWALEAY GAAYTLQEML TVKSDDVSGR
     SKMYESIVKG DFRMDAGMPE SFNVLLKELR SLGIDIELEQ SK
 
 
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