ID   AB38G_ARATH             Reviewed;        1418 AA.
AC   Q7PC85; F4J7V6; Q9LHK8;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=ABC transporter G family member 38;
DE            Short=ABC transporter ABCG.38;
DE            Short=AtABCG38;
DE   AltName: Full=Pleiotropic drug resistance protein 10;
GN   Name=ABCG38; Synonyms=PDR10; OrderedLocusNames=At3g30842; ORFNames=MJI6.3;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Nakamura Y.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. III.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=12430018; DOI=10.1007/s00425-002-0889-z;
RA   van den Brule S., Smart C.C.;
RT   "The plant PDR family of ABC transporters.";
RL   Planta 216:95-106(2002).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA   Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT   "Organization and function of the plant pleiotropic drug resistance ABC
RT   transporter family.";
RL   FEBS Lett. 580:1123-1130(2006).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA   Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA   Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA   Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT   "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL   Trends Plant Sci. 13:151-159(2008).
CC   -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots and siliques at low levels.
CC       {ECO:0000269|PubMed:12430018}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC       PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB02609.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP002043; BAB02609.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE77665.2; -; Genomic_DNA.
DR   EMBL; BK001009; DAA00878.1; -; Genomic_DNA.
DR   RefSeq; NP_001319673.1; NM_001339062.1.
DR   AlphaFoldDB; Q7PC85; -.
DR   SMR; Q7PC85; -.
DR   STRING; 3702.AT3G30842.1; -.
DR   PaxDb; Q7PC85; -.
DR   PRIDE; Q7PC85; -.
DR   ProteomicsDB; 244513; -.
DR   EnsemblPlants; AT3G30842.1; AT3G30842.1; AT3G30842.
DR   GeneID; 822863; -.
DR   Gramene; AT3G30842.1; AT3G30842.1; AT3G30842.
DR   KEGG; ath:AT3G30842; -.
DR   Araport; AT3G30842; -.
DR   eggNOG; KOG0065; Eukaryota.
DR   InParanoid; Q7PC85; -.
DR   OMA; KWLTWAY; -.
DR   OrthoDB; 324553at2759; -.
DR   PhylomeDB; Q7PC85; -.
DR   PRO; PR:Q7PC85; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q7PC85; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   CDD; cd03233; ABCG_PDR_domain1; 1.
DR   CDD; cd03232; ABCG_PDR_domain2; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR029481; ABC_trans_N.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR043926; ABCG_dom.
DR   InterPro; IPR034001; ABCG_PDR_1.
DR   InterPro; IPR034003; ABCG_PDR_2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013581; PDR_assoc.
DR   Pfam; PF01061; ABC2_membrane; 2.
DR   Pfam; PF19055; ABC2_membrane_7; 1.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF14510; ABC_trans_N; 1.
DR   Pfam; PF08370; PDR_assoc; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   2: Evidence at transcript level;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1418
FT                   /note="ABC transporter G family member 38"
FT                   /id="PRO_0000234637"
FT   TRANSMEM        516..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        548..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        600..620
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        634..654
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        659..679
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        729..749
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1167..1187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1197..1217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1249..1269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1284..1304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1310..1330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1341..1361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1387..1407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          147..419
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          497..710
FT                   /note="ABC transmembrane type-2 1"
FT   DOMAIN          821..1073
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          1146..1360
FT                   /note="ABC transmembrane type-2 2"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         179..186
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         866..873
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   1418 AA;  161362 MW;  4547C89AEB3587A4 CRC64;
     MAHYRVSSEV ENIMNRDRSH RKNEEEDEEE ALKLAAMEKL QRLPTYDRAR KAVLKGITGG
     FKEIDMKDLG LAERRELFDR VMTMDDEDWH GEYLRRLKSR FDRVSLHLPT IEVRFEDLNV
     TAEAYAGSKT VPTVLNSYVN LLKGIGTKIR VLPDRKKRIS ILNDVSGIIK PGRLTLLLGP
     PGSGKSTLLK ALSGKTETGL RSTGKVTYNG HELHEFVPER TAGYIDQYDV HLPDLTVRET
     LKFSAKCQGV GTGYDMLAEL LRREKDLNIK PDPYLDALMK ASVIKGHKEY VVTDYVLKVL
     GLEICADTIV GNHMKRGISG GQKKRVTTGE MLVGPVGAFF MDNISDGLDS STTFQIVKSI
     KQMIHVFDKT ALISLLQPPP ETFELFDDVI ILGEGHIVYQ GPREDVLEFF EFMGFKCPER
     KGIADYLQEI LSKKDQEQYW ANPELPYRYV TAKKFEEGFK IHHFGRAMRS QLATPFDRLK
     NHRAALTRTT YGASKLELLK ACLERESILM KRNLRTFVLK SLQLIINAIL IGVVFWQQKN
     YPSTVEDGII YMGAIYLEVQ MIVFSGFFEL PMTIDKLPVF YKQRHFSFYP SWAFSLPTSI
     ITFPLSFVEV FIVVLITYFT IGYDLTVPSF LKHYLVLALC GQMSYGLFRC IAAVTRNHVV
     SNTMGCLAVM WLMTFSGYVL SRNQVHKWLT WAYWTSPMMY IQTAVSVNEF RSESWKDGLG
     VAVLKSRGFF VETYWYWIGL LALILSTILS NIITSLCLAF LKQYGISKTA VLPDEREEAD
     SNNTTGRDYT GTTMERFFDR VVTTRTCNDK KLRIPFKPLY MTFENITYSV DTPKEMKEKG
     IRENKLVLLN GLSGAFRPGV LTALMGVSGA GKTTLMDVLA GRKNTGYIQG EIYVSGFPKK
     QDSFARVSGY CEQSDIHSPL LTVYESLLYS AWLRLPPDID THTRELFIEE VMELIELKAL
     REMLVGYVGI SGLSTEQRKR MTIAVELVAN PSILFMDEPT SGLDARAAAI VMRTVRNTVD
     TGRTVVCTIH QPSIDIFESF DELFLLTRGG EEIYVGPIGH HSSQLIEYFE GIRGVGKIKE
     GYNPATWALE VTTRAQEDVL GVTFAQVYKK SNLYRRNKDL IKELNNIPPH AQDIHFSTKY
     SQSYLSQFQA CLWKQHKSYW RNVPYNAVRF SFGAAVGIMY GIIFWSLGKR KGTRQDIFNS
     VGAMSTVVGF LSSQSAATVR PVVIAERTVF YREAGAGMYS ALPYAFSQVI IEIPYTMAQA
     CIYGVIVYGM IGYEWTASKF FLNIFFTFIS ILYSIYTGIM VISVSPNQEI ASILNGVIST
     SWNVFSGFTI PRPRMHVWLR WFTYVCPGWW GLYGLTIAQY GDVETRLDTG ETVVEFMKNY
     YGYEYNFLWV VSLTLIAFSM FFVFIYAFSV KILNFQKR