ID   ATR1_STAC4              Reviewed;         234 AA.
AC   A0A084R1N2;
DT   22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Core atranone cluster (CAC) protein 1 {ECO:0000303|PubMed:25015739};
GN   Name=ATR1 {ECO:0000303|PubMed:25015739}; ORFNames=S40285_10095;
OS   Stachybotrys chlorohalonata (strain IBT 40285).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Stachybotryaceae; Stachybotrys.
OX   NCBI_TaxID=1283841;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION, AND
RP   FUNCTION.
RC   STRAIN=IBT 40285;
RX   PubMed=25015739; DOI=10.1186/1471-2164-15-590;
RA   Semeiks J., Borek D., Otwinowski Z., Grishin N.V.;
RT   "Comparative genome sequencing reveals chemotype-specific gene clusters in
RT   the toxigenic black mold Stachybotrys.";
RL   BMC Genomics 15:590-590(2014).
CC   -!- FUNCTION: Part of the core atranone cluster (CAC) which products are
CC       predicted to catalyze most or all steps of mycotoxin atranone
CC       synthesis, starting from geranylgeranyl pyrophosphate (GGPP)
CC       (PubMed:25015739). The initial cyclization of GGPP to dolabellane is
CC       probably performed by the terpene cyclase ATR13 (PubMed:25015739). The
CC       Baeyer-Villiger oxidation near the end of the atranone synthesis, which
CC       converts atranones D and E to atranones F and G is predicted to be
CC       catalyzed by the monooxygenase ATR8 (PubMed:25015739). Of the CAC's
CC       other predicted gene products, the reducing PKS ATR6 might synthesize a
CC       polyketide chain (PubMed:25015739). This polyketide is probably
CC       transferred onto the atranone backbone by the polyketide transferase
CC       ATR5 (By similarity). Other predicted CAC products include 4 oxygenases
CC       (ATR2, ATR3, ATR4, and ATR14), 3 short-chain reductases (ATR7, ATR9,
CC       and ATR10), and a methyltransferase (ATR12) (PubMed:25015739). These
CC       may all be involved in the various steps of atranone biosynthesis,
CC       although their specific roles must await experimental determination
CC       (PubMed:25015739). {ECO:0000250|UniProtKB:Q4WAY4,
CC       ECO:0000305|PubMed:25015739}.
CC   -!- PATHWAY: Mycotoxin biosynthesis. {ECO:0000305|PubMed:25015739}.
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DR   EMBL; KL659308; KFA70117.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A084R1N2; -.
DR   EnsemblFungi; KFA70117; KFA70117; S40285_10095.
DR   HOGENOM; CLU_1300163_0_0_1; -.
DR   OrthoDB; 1338599at2759; -.
DR   Proteomes; UP000028524; Unassembled WGS sequence.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..234
FT                   /note="Core atranone cluster (CAC) protein 1"
FT                   /id="PRO_0000442388"
SQ   SEQUENCE   234 AA;  26409 MW;  2E69D5A8B3B19917 CRC64;
     MASIPGLLFS LTKPMDPTIP EAQFNDWYTN KHLVDTVNSG LASLAVRFKN VNPSHQWPYL
     ALYRLQDLAK LYNMEFMSSL PTDSPAGWGV PNSKADIRIE PRGYQLLTTL ERENAKTGVP
     KFVLTVEFRE SFMNAEAFVA SCQGLQLDDV GKQPGYRRSM LYQAGRSLVT QEGKAGTEFR
     SAEQQQPSYL VVHEFDQMPT NTFQEQGASG LWEYMAEYGT GLYRTEPVPV KVYN