ID   RPOB_ANADE              Reviewed;        1422 AA.
AC   Q2II86;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Adeh_1592;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N.,
RA   Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R.,
RA   Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; CP000251; ABC81365.1; -; Genomic_DNA.
DR   RefSeq; WP_011420648.1; NC_007760.1.
DR   AlphaFoldDB; Q2II86; -.
DR   SMR; Q2II86; -.
DR   STRING; 290397.Adeh_1592; -.
DR   EnsemblBacteria; ABC81365; ABC81365; Adeh_1592.
DR   KEGG; ade:Adeh_1592; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_0_7; -.
DR   OMA; FMTWEGY; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 2.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..1422
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000237295"
FT   REGION          1392..1422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1422 AA;  159068 MW;  BC0B453BB27752E7 CRC64;
     MATTIQNNFR IRRNFGKINK IAEIPNLIAI QKFSYDKFLQ ADVPPEKRDD TGLQGVFKSV
     FPIKDFNETS SLEFVSYHLE KPKYDVDECH QRGMTYSAPI KVVVRLVVWD KDEETGAQSI
     RDVKEQEVYF GEIPLMTENG TFIINGTERV VVSQLHRSPG AFFDHDKGKS HSSGKLLYNA
     RIIPYRGSWI DFEFDHKDIL YVRIDRRRKL PATVLLRALG ATPDTAKKDP VEFHGSAEEI
     LKYYYDTETI RVEGKGKFEK DLVPDLLKGQ RATRDIRDPK SSEVIVKKNR KYTESAIKKL
     VAAKMKSLPV EPEEVYTKIS AEDVVDETTG EVLLEVNEEV TEAKVEELRK RNINEFKVLF
     IDNLNILPAL RDTLMQDKIS TPEEAIMEIY RRLRPGDPPT PETATNLFVN LFFNAERYDL
     SKVGRLKLNY KFGIEEPLEN TVLTKRDILE VVRFLIDLKN GKPNKDVDDI DHLGNRRVRA
     VGELLENQYR IGLVRMERAI KERMSLQEIE TLMPHDLINA KPVTAVIKEF FGSSQLSQFM
     DQTNPLSEVT HKRRLSALGP GGLTRERAGF EVRDVHSTHY GRICPIETPE GPNIGLIASL
     STYARVNEYG FVETPYRKVE KGRVTDEVTF YSALEEEKHI IAQANAPVDK KGNFTEAKVW
     CRKEGEYIYV RPDEVDLMDV SPNQLVSVAA SLVPFLENDD ANRALMGSNM QRQAVPLLRT
     QAPLVGTGIE AIVARDSGVT TVAKRDGVVQ SVDASRIVVK ADVPTSATDV ANEVDIYNLI
     KYQRSNQNTC INQKPIVKPG ERVRKGDVIA DGPATEMGEL ALGQNVVVAF MPWQGYNFED
     SILLSERLIK EDVFTSVHIE EFECVARDTK LGKEEITRDI PNVGEEALKD LDESGIIRIG
     AEVKPGDILV GKITPKGETQ LSPEEKLLRA IFGEKAGDVR DSSLRVPPGV SGTVINAKVF
     SRKGVEKDER AKAIEEMEEA KLLKDQNDEI RIIQDSAFQK IRRLLLGKEV TARLVDDKGE
     QLLKKGDVLD DALLDTVPQR YWGEIAVAGD VQDLARKIID NFEEQKELVK LLFGEKIGRL
     KKGDELPPGV IKMVKVYVAI KRKLAVGDKM AGRHGNKGVV SRVLPEEDLP YLEDGTPVDI
     VLNPLGVPSR MNVGQILETH LGWAARNVGL RLQEMIEKEY GPEQLRKKLR AAFAGTEGGP
     ASDRLAALID DVPEKELPKL AQKLRRGMHV ATPVFDGARE DEMKALMEEG SATLQSILFD
     GRTGEPFDQD VTVGVMYMLK LHHLVDEKIH ARSIGPYSLV TQQPLGGKAQ FGGQRLGEME
     VWAMEAYGAA YSLQEFLTVK SDDVVGRTRM YEAIVKGENT LESGLPESFN VLIKELQSLA
     LDVELLETPE AQAAREAAER DLGGGPLGAP RGAVASGEKS SA