ID   RPOB_ANAPZ              Reviewed;        1383 AA.
AC   Q2GJ68;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=APH_1024;
OS   Anaplasma phagocytophilum (strain HZ).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Anaplasma; phagocytophilum group.
OX   NCBI_TaxID=212042;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HZ;
RX   PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA   Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA   Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA   Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.C.,
RA   Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C.,
RA   Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D.,
RA   Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA   Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT   "Comparative genomics of emerging human ehrlichiosis agents.";
RL   PLoS Genet. 2:208-222(2006).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000235; ABD43405.1; -; Genomic_DNA.
DR   RefSeq; WP_011451096.1; NC_007797.1.
DR   AlphaFoldDB; Q2GJ68; -.
DR   SMR; Q2GJ68; -.
DR   STRING; 212042.APH_1024; -.
DR   PRIDE; Q2GJ68; -.
DR   EnsemblBacteria; ABD43405; ABD43405; APH_1024.
DR   KEGG; aph:APH_1024; -.
DR   PATRIC; fig|212042.8.peg.1099; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_1_5; -.
DR   OMA; FMTWEGY; -.
DR   OrthoDB; 9601at2; -.
DR   Proteomes; UP000001943; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 1.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..1383
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000237296"
SQ   SEQUENCE   1383 AA;  154523 MW;  1FFFF1FC0A6724B3 CRC64;
     MSSAGDSGPG YVLNDFDAVP RLSYARSIDI RDSLSDLIRI QRDSYDAFIG IDEGSSGGIQ
     SIFQSMFPIR DPLGRAVLEF VSCNIGEPQY DEYECIKRGI TFSVPMRITL RFVVWKVQEV
     SFKEVKYVVD EGTLERSVKY MKEQEVSIGD LPMMTSYGTF IINGIERVIV SQMHRSPGVF
     FDSDKGKTYS SGKLIYSARI IPYRGSWLDF EFDIKDIIYF RIDKKRKLPV TYLLKALGMS
     NNDILDTFYD KVLYVRSDKG WKVPFVVDRF KGVRLSYDLM DVDGNVLIKA NTRITLRIAK
     KLYADGLREY LVPFAGISGL FVATDLVDPA SGAVIVSAGE AIAAEHIVKL ELFDISEIAF
     LNIDFLTVGP YVLNTLFLDR HITQEDALFE IYRVLRSGES PNLEAVKSFF KGLFFEPDRY
     DLSVVGRIKL NSHLRLDIDE NLTVLTKDDI VHVIKKLVLL PDGEGVVDDI DHLGNRRVRS
     VGEFIENQFR VGILRLERMI MDYMSSVNFD NAVPCDFVNP KILATVLKDF FSSSQLSQFM
     DQTNPLSEVT HKRRLSALGP GGLTRERAGF EVRDVHPTHY GRICPIETPE GQNIGLISSL
     AIYAKINKYG FIESPYRKVI DGVVTDSVEY LLATQESDYY IADAGAALDE NNRFVDDMLY
     CRHGGNFVMV KREDVNYIDV SPKQIVSVAA SLIPFLENND ANRALMGSNM QRQAVPLLKA
     EAPLVGTGME SVVAAGSGAV VLAKRDGVVH RVDGSYIVIR AFDKNKDEYL GVDIYKLRKF
     QRSNHNTCIN QRPIVKIGDY VRTNDVIADG AAIDRGELAL GKNVLVAFMS WQGYNFEDSI
     VISSDVVKRD VFTSIHIEEF ECVVRDTPLG PEKIMRSVPD VNEESLSHLD DVGIVNIGAE
     VSAGSVLVGK VTPRPPVSLP PETKLLVTIF GEKVFDCVDS SLYLPPDVEG TVIDVHVFVR
     RGVEENDRSL LIKQSEVNSF RKERDYEIDV VSEYFYDELK KLLCSADLPL NGHADVESLL
     AAKSLEALWE IGLSNPKISA KVADMKGKFD ELITEAHSKF DQKIDKLNYG YDLPQGVLTI
     VKVFVAVKHN LQPGDKMAGR HGNKGVISRI VPVEDMPHLE DGTPVDIILN SLGVPSRMNI
     GQILETHLGW AAVNLGHRVG RMLDSGEEEG PVVESIRSFL SEVYEGQKLK EDVASMSDEA
     LLKFANRLRR GVPMAAPVFE GPKDAQISRL LELADVDPSG QVDLYDGRSG QKFDRKVTVG
     YIYMLKLHHL VDDKIHARSV GPYGLVTQQP LGGKSHFGGQ RFGEMECWAL QAYGAAYTLQ
     EMLTVKSDDI VGRVRIYESI IKGDSNFECG IPESFNVMVK ELRSLCLDVV LKQDKEFTSS
     KVE