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RPOB_AQUAE
ID   RPOB_AQUAE              Reviewed;        1468 AA.
AC   O67762;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=aq_1939;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; AE000657; AAC07723.1; -; Genomic_DNA.
DR   PIR; F70466; F70466.
DR   RefSeq; NP_214331.1; NC_000918.1.
DR   RefSeq; WP_010881267.1; NC_000918.1.
DR   AlphaFoldDB; O67762; -.
DR   SMR; O67762; -.
DR   STRING; 224324.aq_1939; -.
DR   EnsemblBacteria; AAC07723; AAC07723; aq_1939.
DR   KEGG; aae:aq_1939; -.
DR   PATRIC; fig|224324.8.peg.1501; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_1_0; -.
DR   InParanoid; O67762; -.
DR   OMA; FMTWEGY; -.
DR   OrthoDB; 9601at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 1.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..1468
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000047855"
SQ   SEQUENCE   1468 AA;  167388 MW;  9182372EA417930E CRC64;
     MAKIALPRKF FGRRFEVLEP PYLLSIPKNS FENFVQLKVN PYKRKNVGLE HIFRTSFPFK
     DPDENFILEY LGYEIGDWEC NRCGYKPKDD LLGGWDVDCP QCGAKLVYKE KFTPEECKLK
     GLTYSAPLRV MLQLKAKTKN GYREFPPKKV YFGEIPLMTE TGSFIINGTE RIIINQLIRS
     SGVFFDEKEE KQKDATITRI LYRGSIIPDK GSRVEFELSG ATDLISARID RKKLSATAVL
     RAFGLETAYD ILKYFYEDVR KFIVKDKYLY DAQTGEEFTP EDLEHHYIFA IIKFRGKLVG
     FASSKERDFI EERYIEEWED LVRLLDDDRI EVLSVTAVPR DVVIKSPYGK SLIDTLANDT
     SPKDVDKRSP VKVPAEYTLR DYGLMEMYKR LRHIEAITME IDSVIERARI FFNVFFRDLK
     RYDLSRVGRV KINAKVHRIP KVLKPADVDL LDQLPPLALA EDYGEYKAGT RVTKDLLKEL
     FKQYKEIKVK DYTEDEARFI LPIDLVNILK YLIDLRHGRV KKDDIAHLGN RRVRSVGELL
     ENQARLGIAK MEKVFRDRSA VINPEQPDLK PQDFINPRYV TTAITDFLKT GQLSQYLDNT
     NPLSELTHKR RLSALGPGGL TRESAKFEIR DVHPSHYGRI CPIETPEGQN IGLVTSPTVY
     ARVNEYGFLI TPYRKVENGK VTDKIEWLAA YEEENYVIAQ STPTDEEGRL KAEFILARHK
     NDIRLVKPEQ VEYIDVSPRQ VISPSSSLIP FLEHDDANRA LMGSNMQRQA VPLIFTQAPL
     IGTGMEKKIA RDSHAVVVAK RGGVVEEVDS SKIIIRVNPE EINFDDPLDI GIDIYELRKF
     QRTNQKTCVN QRPIVRKGEK VEKGQIIADG HSTDRGELAL GKDVLVAFMP WRGYNFEDAI
     VISERLVKED VYTSIHIEEL EVEARETKVG EEEITRQIPG VPERALAHLD EHGIVRVGTY
     VKPGDILVGK VTPKGETRLT PEEKLLQAIF GEKTRDVKDA SLRCPPGVEG IVIDVQVFTR
     KGTGKKDMLA EKVEREELEA LEQELEKKKN LIITGRDKVL KGLVLGRKVE KDAKVGRKTV
     KKGTVIDEKV FEEFVNYILG RPENFFEDED LIRKIREIAE RTRTQIEMLN KVYEEKKETL
     LKRRDLPPGV ITLVKVFIAN KRKIKVGDKM AGRHGNKGVI SVVLPVEDMP FLPDGTPVDI
     VLNPLGVPSR MNVGQILETH LGWAAKELGK KIGEMIEKGR DRKAITEYLK EIFAIGDKDG
     ENAKFIEEFL NSLSEEEFWS VVRDYAERGI PMATPAFEGA EEDAIKELLK KAGLPENGKT
     TLYDGRTGEP FDFEVTVGYM HMLKLIHMVD DKIHARATGP YSLVTQQPLG GRAQFGGQRL
     GEMEVWALEA HGAAYTLQEM LTVKSDDVEG RTKVYEAIVK GKYTYTPGIP ESFKVLVREL
     KALGLNVKCL NGEEKPCDEV EVKEEEEK
 
 
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