RPOB_BACSU
ID RPOB_BACSU Reviewed; 1193 AA.
AC P37870;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321, ECO:0000269|PubMed:18289874};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; Synonyms=crsE, rfm;
GN OrderedLocusNames=BSU01070;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC 3610 / NRRL NRS-744 / VKM B-501;
RX PubMed=7657605; DOI=10.1074/jbc.270.35.20329;
RA Boor K.J., Duncan M.L., Price C.W.;
RT "Genetic and transcriptional organization of the region encoding the beta
RT subunit of Bacillus subtilis RNA polymerase.";
RL J. Biol. Chem. 270:20329-20336(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP SEQUENCE REVISION TO 1073-1074.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [4]
RP SUBUNIT.
RC STRAIN=168;
RX PubMed=6802805; DOI=10.1128/jb.150.2.977-980.1982;
RA Achberger E.C., Tahara M., Whiteley H.R.;
RT "Interchangeability of delta subunits of RNA polymerase from different
RT species of the genus Bacillus.";
RL J. Bacteriol. 150:977-980(1982).
RN [5]
RP MUTAGENESIS TO STREPTOLYDIGAN RESISTANCE.
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC 3610 / NRRL NRS-744 / VKM B-501;
RX PubMed=7592585; DOI=10.1074/jbc.270.41.23930;
RA Yang X., Price C.W.;
RT "Streptolydigin resistance can be conferred by alterations to either the
RT beta or beta' subunits of Bacillus subtilis RNA polymerase.";
RL J. Biol. Chem. 270:23930-23933(1995).
RN [6]
RP FUNCTION, AND SUBUNIT.
RC STRAIN=BS200;
RX PubMed=18289874; DOI=10.1016/j.pep.2008.01.006;
RA Yang X., Lewis P.J.;
RT "Overproduction and purification of recombinant Bacillus subtilis RNA
RT polymerase.";
RL Protein Expr. Purif. 59:86-93(2008).
RN [7]
RP SUBUNIT.
RC STRAIN=168;
RX PubMed=21710567; DOI=10.1002/pmic.201000790;
RA Delumeau O., Lecointe F., Muntel J., Guillot A., Guedon E., Monnet V.,
RA Hecker M., Becher D., Polard P., Noirot P.;
RT "The dynamic protein partnership of RNA polymerase in Bacillus subtilis.";
RL Proteomics 11:2992-3001(2011).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000269|PubMed:18289874}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321,
CC ECO:0000269|PubMed:18289874};
CC -!- SUBUNIT: RNAP is composed of a core of 2 alpha, a beta and a beta'
CC subunit. The core is associated with a delta subunit, and at least one
CC of epsilon or omega (PubMed:6802805, PubMed:18289874, PubMed:21710567).
CC When a sigma factor is associated with the core the holoenzyme is
CC formed, which can initiate transcription (PubMed:18289874).
CC {ECO:0000255|HAMAP-Rule:MF_01321, ECO:0000269|PubMed:18289874,
CC ECO:0000269|PubMed:21710567, ECO:0000269|PubMed:6802805}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; L24376; AAB00972.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB11883.2; -; Genomic_DNA.
DR PIR; F69698; F69698.
DR RefSeq; NP_387988.2; NC_000964.3.
DR RefSeq; WP_009966326.1; NZ_JNCM01000029.1.
DR PDB; 2LY7; NMR; -; A=784-923.
DR PDB; 6WVJ; EM; 3.36 A; C=1-1193.
DR PDB; 6WVK; EM; 3.36 A; C=1-1193.
DR PDB; 6ZCA; EM; 4.20 A; X=1-1193.
DR PDB; 6ZFB; EM; 3.90 A; X/x=1-1193.
DR PDB; 7CKQ; EM; 4.40 A; C=1-1193.
DR PDB; 7F75; EM; 4.20 A; C=1-1193.
DR PDBsum; 2LY7; -.
DR PDBsum; 6WVJ; -.
DR PDBsum; 6WVK; -.
DR PDBsum; 6ZCA; -.
DR PDBsum; 6ZFB; -.
DR PDBsum; 7CKQ; -.
DR PDBsum; 7F75; -.
DR AlphaFoldDB; P37870; -.
DR SMR; P37870; -.
DR DIP; DIP-49021N; -.
DR IntAct; P37870; 12.
DR MINT; P37870; -.
DR STRING; 224308.BSU01070; -.
DR jPOST; P37870; -.
DR PaxDb; P37870; -.
DR PRIDE; P37870; -.
DR EnsemblBacteria; CAB11883; CAB11883; BSU_01070.
DR GeneID; 936335; -.
DR KEGG; bsu:BSU01070; -.
DR PATRIC; fig|224308.179.peg.110; -.
DR eggNOG; COG0085; Bacteria.
DR InParanoid; P37870; -.
DR OMA; FMTWEGY; -.
DR PhylomeDB; P37870; -.
DR BioCyc; BSUB:BSU01070-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antibiotic resistance; DNA-directed RNA polymerase;
KW Nucleotidyltransferase; Reference proteome; Transcription; Transferase.
FT CHAIN 1..1193
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000047860"
FT REGION 1149..1193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 482
FT /note="H -> Y (in rfm2103; rifampicin resistant)"
FT MUTAGEN 499..502
FT /note="Missing: Not streptolydigan resistant."
FT /evidence="ECO:0000269|PubMed:7592585"
FT MUTAGEN 499
FT /note="A->V: Streptolydigan resistant."
FT /evidence="ECO:0000269|PubMed:7592585"
FT MUTAGEN 500
FT /note="G->R: Streptolydigan resistant."
FT /evidence="ECO:0000269|PubMed:7592585"
FT MUTAGEN 501
FT /note="M->S: Not streptolydigan resistant."
FT /evidence="ECO:0000269|PubMed:7592585"
FT MUTAGEN 502
FT /note="E->V: Streptolydigan resistant."
FT /evidence="ECO:0000269|PubMed:7592585"
FT CONFLICT 1073..1074
FT /note="QR -> HG (in Ref. 1; AAB00972)"
FT /evidence="ECO:0000305"
FT STRAND 4..8
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 9..11
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 12..16
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 31..42
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 44..52
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 53..56
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 63..71
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 80..83
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 89..99
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 106..117
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 121..123
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 125..127
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 130..134
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 136..140
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 143..147
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 152..154
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 159..162
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 165..167
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 171..174
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 180..187
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 192..197
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 198..200
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 204..210
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 217..223
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 229..238
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 248..258
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 262..264
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 269..279
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 282..285
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 290..292
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 338..340
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 346..350
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 353..355
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 360..364
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 378..392
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 404..406
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 407..409
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 412..438
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 445..447
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 452..464
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 466..470
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 476..482
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 485..487
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 496..498
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 501..504
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 508..510
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 511..513
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 523..527
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 528..531
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 539..541
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 543..550
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 552..554
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 556..565
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 568..571
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 583..585
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 587..598
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 600..604
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 605..607
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 615..617
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 621..625
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 629..631
FT /evidence="ECO:0007829|PDB:6WVK"
FT HELIX 634..644
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 657..659
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 663..669
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 673..675
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 680..686
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 689..694
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 698..700
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 707..711
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 715..717
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 721..724
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 741..744
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 756..763
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 768..770
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 773..778
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 780..783
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 786..800
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 803..806
FT /evidence="ECO:0007829|PDB:6WVK"
FT STRAND 814..816
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 820..822
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 826..830
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 841..847
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 856..865
FT /evidence="ECO:0007829|PDB:2LY7"
FT STRAND 873..878
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 885..894
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 895..897
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 903..918
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 924..926
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 928..930
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 933..939
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 941..943
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 954..957
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 961..964
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 968..983
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 991..994
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 997..1007
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 1011..1013
FT /evidence="ECO:0007829|PDB:6WVK"
FT STRAND 1020..1022
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 1032..1039
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 1044..1047
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 1049..1053
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 1058..1060
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 1067..1069
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 1073..1075
FT /evidence="ECO:0007829|PDB:6WVK"
FT HELIX 1077..1086
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 1089..1096
FT /evidence="ECO:0007829|PDB:6WVJ"
FT TURN 1097..1099
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 1103..1115
FT /evidence="ECO:0007829|PDB:6WVJ"
FT HELIX 1126..1137
FT /evidence="ECO:0007829|PDB:6WVJ"
FT STRAND 1146..1149
FT /evidence="ECO:0007829|PDB:6WVJ"
SQ SEQUENCE 1193 AA; 133686 MW; 713FFF19F0987443 CRC64;
MTGQLVQYGR HRQRRSYARI SEVLELPNLI EIQTSSYQWF LDEGLREMFQ DISPIEDFTG
NLSLEFIDYS LGEPKYPVEE SKERDVTYSA PLRVKVRLIN KETGEVKDQD VFMGDFPIMT
DTGTFIINGA ERVIVSQLVR SPSVYFSGKV DKNGKKGFTA TVIPNRGAWL EYETDAKDVV
YVRIDRTRKL PVTVLLRALG FGSDQEILDL IGENEYLRNT LDKDNTENSD KALLEIYERL
RPGEPPTVEN AKSLLDSRFF DPKRYDLANV GRYKINKKLH IKNRLFNQRL AETLVDPETG
EILAEKGQIL DRRTLDKVLP YLENGIGFRK LYPNGGVVED EVTLQSIKIF APTDQEGEQV
INVIGNAYIE EEIKNITPAD IISSISYFFN LLHGVGDTDD IDHLGNRRLR SVGELLQNQF
RIGLSRMERV VRERMSIQDT NTITPQQLIN IRPVIASIKE FFGSSQLSQF MDQTNPLAEL
THKRRLSALG PGGLTRERAG MEVRDVHYSH YGRMCPIETP EGPNIGLINS LSSYAKVNRF
GFIETPYRRV DPETGKVTGR IDYLTADEED NYVVAQANAR LDDEGAFIDD SIVARFRGEN
TVVSRNRVDY MDVSPKQVVS AATACIPFLE NDDSNRALMG ANMQRQAVPL MQPEAPFVGT
GMEYVSGKDS GAAVICKHPG IVERVEAKNV WVRRYEEVDG QKVKGNLDKY SLLKFVRSNQ
GTCYNQRPIV SVGDEVVKGE ILADGPSMEL GELALGRNVM VGFMTWDGYN YEDAIIMSER
LVKDDVYTSI HIEEYESEAR DTKLGPEEIT RDIPNVGEDA LRNLDDRGII RIGAEVKDGD
LLVGKVTPKG VTELTAEERL LHAIFGEKAR EVRDTSLRVP HGGGGIIHDV KVFNREDGDE
LPPGVNQLVR VYIVQKRKIS EGDKMAGRHG NKGVISKILP EEDMPYLPDG TPIDIMLNPL
GVPSRMNIGQ VLELHMGMAA RYLGIHIASP VFDGAREEDV WETLEEAGMS RDAKTVLYDG
RTGEPFDNRV SVGIMYMIKL AHMVDDKLHA RSTGPYSLVT QQPLGGKAQF GGQRFGEMEV
WALEAYGAAY TLQEILTVKS DDVVGRVKTY EAIVKGDNVP EPGVPESFKV LIKELQSLGM
DVKILSGDEE EIEMRDLEDE EDAKQADGLA LSGDEEPEET ASADVERDVV TKE
