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RPOB_BIFLD
ID   RPOB_BIFLD              Reviewed;        1187 AA.
AC   B3DTE2;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=BLD_0965;
OS   Bifidobacterium longum (strain DJO10A).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=205913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DJO10A;
RX   PubMed=18505588; DOI=10.1186/1471-2164-9-247;
RA   Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R.,
RA   Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V.,
RA   Slesarev A.I., Weimer B., O'Sullivan D.J.;
RT   "Comparative genomic analysis of the gut bacterium Bifidobacterium longum
RT   reveals loci susceptible to deletion during pure culture growth.";
RL   BMC Genomics 9:247-247(2008).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; CP000605; ACD98411.1; -; Genomic_DNA.
DR   RefSeq; WP_010080834.1; NZ_AABM02000002.1.
DR   AlphaFoldDB; B3DTE2; -.
DR   SMR; B3DTE2; -.
DR   PRIDE; B3DTE2; -.
DR   EnsemblBacteria; ACD98411; ACD98411; BLD_0965.
DR   KEGG; blj:BLD_0965; -.
DR   HOGENOM; CLU_000524_4_1_11; -.
DR   OMA; FMTWEGY; -.
DR   Proteomes; UP000002419; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 1.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW   Transferase.
FT   CHAIN           1..1187
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_1000141661"
FT   REGION          1150..1187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1173..1187
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1187 AA;  131644 MW;  42DCB12C1D7F31C8 CRC64;
     MATESTTNTT TIIARADQHD IDLHKASDRV NFGSIKEPID VPYLLGVQTD SFDWLIGNER
     WKARVEEDEK NGTNTVAHTS GLDEVFNEIS PIENFAQTMS LTFSDPYFEE PRHTVQECKE
     KDYTYSAPLY VNAEFENGDT GEIKSQTVFM GDFPLQTPHG TFIIGGTERV IVSQLVRSPG
     VYFDRQQDRT SDKEVFGAKI IPSRGAWLEF EIDKKDQPQV RVDRKRKQSA IVFLMAIGMT
     KSEIAQAFKD YPLVLDALEK ETLGTQDEAL VDLYRKIRPA DTPTPEAGKN LLDSFYFNTK
     RYDLARVGRY KINRKLGVEA DFNDRSLHQE DIIATIKYLV ALHDGAATFP GKRNGEDVDL
     RVDVDDIDHF GNRRIRQVGE LIQNQLRTGL SRMERVVRER MTTQDAEAIT PQSLINIRPV
     NATIKEFFGT SQLSQFMDQN NPLSGVTNKR RLSALGPGGL SRDRASMEVR DVHPSHFGRM
     CPIESPEGPN IGLIGSLATF GRVNPFGFIE TPYRKVVNGH VTDEVEYMTA DRDLDHVIAQ
     ANQELDENGN FVQKSALARV GEEEAVDVPV SSVDYMDVSP RQMVSLGASL IPFLEHDEGH
     RALMGTNMQR QAVPLIESER PLVGTGSEWR AANDSGDVIK SEKDGVVTYV SADLIRVMND
     DGTTSSYKLA KFQRSNQTTC YNQRPIVHDG ERVEAGSVMA DGPAIQNGDL ALGKNLLIAF
     MPWNGYNYED AVIISQRLVQ DDTLSSIHIE EYEIDARETK LGAEEITRDL PNVGEDAVAN
     LDERGIIRIG AEVEAGDILV GKVTPKGETE LTPEERLLRA IFGEKSREVR DTSLRVPHGE
     TGTVIGVKEI TREDAEEDGD ELPNGVNQMI RVYIAQHRKI TVGDKLSGRH GNKGCISRIL
     PEEDMPFLAD GTPVDIMLNP LGVPSRMNLG QVLELHLGWI AHSGWDISLD PNLEAEWKKL
     IPSGAEKAEP NTPVATPVFD GVKPEVLKGL LSTTLPNRDG DRLVGPDGKA TLFDGRTGEP
     YTKPISVGYM YMLKLHHLVD DKIHARSTGP YSMITQQPLG GKAQFGGQRF GEMEVWALEA
     YGAAYTLHEM MTTKSDDVDG RVRVYGAIVK GDNLPPAGIP ESFKVLLKEM QSLSLNVEVL
     NAEGVAIDMK DEDDDPASSA DDLGFNIGAR PDAAAKEDQK AEEPEYQ
 
 
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