RPOB_BLOPB
ID RPOB_BLOPB Reviewed; 1341 AA.
AC Q492B9;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=BPEN_577;
OS Blochmannia pennsylvanicus (strain BPEN).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; ant endosymbionts; Candidatus Blochmannia.
OX NCBI_TaxID=291272;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BPEN;
RX PubMed=16077009; DOI=10.1101/gr.3771305;
RA Degnan P.H., Lazarus A.B., Wernegreen J.J.;
RT "Genome sequence of Blochmannia pennsylvanicus indicates parallel
RT evolutionary trends among bacterial mutualists of insects.";
RL Genome Res. 15:1023-1033(2005).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000016; AAZ41183.1; -; Genomic_DNA.
DR RefSeq; WP_011283094.1; NC_007292.1.
DR AlphaFoldDB; Q492B9; -.
DR SMR; Q492B9; -.
DR STRING; 291272.BPEN_577; -.
DR PRIDE; Q492B9; -.
DR EnsemblBacteria; AAZ41183; AAZ41183; BPEN_577.
DR KEGG; bpn:BPEN_577; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_3_6; -.
DR OMA; FMTWEGY; -.
DR BioCyc; CBLO291272:BPEN_RS02845-MON; -.
DR Proteomes; UP000007794; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW Transferase.
FT CHAIN 1..1341
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000224033"
SQ SEQUENCE 1341 AA; 151222 MW; 237471DDE08929E3 CRC64;
MVYSYTEKKR IRKDFGKRPQ VLDIPYLLSI QIDSFQKFIK QDPEEPCGLE AAFRSVFPIK
SYNGNAELQY IKYQLGEPTF DVKECQTRGA TFSAPLRVRL CLIIYEREGL NNIIKNTKEQ
EVYMGEIPLM TNNGTFIING IERVIVSQLH RSPGVFFDSD KGKTHSSGKV LYNARIIPYR
GSWLDFEFDL KDNLFVRIDR RRKLPVTVIL RALNYTTDQI LNIFFNKVIY EIQNNTLYMH
LIPERLRGET ASFDIAVNGV IYVKKGRRIA AKHIRQLKKD KISKIEVPMD YIIGKVVIKD
YFDKNTNIPI VTANTEISSD ILHNLIRSGY ESIETLFSND LDYGNYISET LRIDATTNKF
DALVEIYRVM RPGEPPTKEA AEYLFENLFF SEERYDLSSV GRMKFNRSLQ RVQIEDLGTL
KKDDIVDVIK KLIDIRNGKG EVDDIDHLGN RRIRSVGEMA ENQFRIGLVR VERAVKERLS
LGDLDVLTPQ DLINAKPISA AVREFFTSSQ LSQFMDQNNP LSEITHKRRI SALGPGGLTR
ERAGFEVRDV HPTHYGRVCP IETPEGPNIG LINSLSVYAR ANKYGFLETP YRKVQNGVVS
NDIHYLSAIE EGDFVIAQAN TNLNSIGEFI DDLVTCRNKG ESGLFKKDQV DYMDVSTQQI
VSVAASLIPF LEHDDANRAL MGANMQRQAV PVLCSEKPLV GTGMERAVAI DSGVTVVAKR
GGVIKYVDAS RIVIHVNKNE THTEESGIDI YQLTKYIRSN QNTCINQRPC VSLGELVEHG
DVIADGPSTD LGELALGQNM RIAFMPWNGY NFEDSMLVSE RVVQEDKFTS IHIQELTCVS
RDTKLGPEEI TADIPNVGET ALSKLDESGI IYIGAEVIGG DILVGKVTPK GETQLTPEEK
LLRAIFGEKA SDVKDSSLRV PNGVCGTVID VQIFTRDGIN KDKRSLIIES EKLKQVKKDL
SEELQIFESA LFDRVCDVLM TSGIDKKKLF ETSRNAWLDL VLSDPEKQYQ LSQLTKQYFD
LKRMFEKKLE IQHRKITQGD ELAPGILKIV KVYLAVKRQI QPGDKMAGRH GNKGVISKIN
PIEDMPYDQH GIPVDIVLNP LGVPSRMNIG QILETHLGMA AKGIGDKINF MLQQHKEANQ
LRRFMQQAYN LGEGSRQHIN LNSFSDIEIL KLAKNLKKGM PIATPVFDGA TEKEIKDLLK
LSGLPSSGQI TLFDGCTGEA FERQVTVGYM YMLKLNHLVD DKMHARSTGS YSLVTQQPLG
GKAQFGGQRF GEMEVWALEA YGASYTLQEM LTVKSDDVNG RTKMYKNIVD GNHMMEPGMP
ESFNVLLKEI RSLAINIELE D
